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Tbio
ORM1
Alpha-1-acid glycoprotein 1

Protein Summary
Description
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259396
  • ENSP00000259396
  • ENSG00000229314

Symbol
  • AGP1
  • ORM
  • AGP1
  • AGP-A
  • HEL-S-153w
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
cell type or tissue
0.76
chemical
0.67
biological term
0.65
disease
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.69   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 567   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.69   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
1
3
85.7
tumor necrosis factor receptor 1 measurement
1
1
1
47.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
85.7
tumor necrosis factor receptor 1 measurement
1
47.4
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
alpha-1-acid glycoprotein 2-like
100050100
Species
Name
OMA
EggNOG
Inparanoid
Horse
alpha-1-acid glycoprotein 2-like
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02763-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Platelet activation, signaling and aggregation
Gene Ontology Terms (18)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (225)
1 – 10 of 225
ORM2
Tbio
Novelty: 0.00837073
p_int: 0.999999818
p_ni: 1.4e-8
p_wrong: 1.68e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999943914
p_ni: 0.000056086
Score: 0.51
Data Source: BioPlex,STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999674495
p_ni: 0.000323771
p_wrong: 0.000001733
Data Source: BioPlex
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999662262
p_ni: 0.000337468
p_wrong: 2.69e-7
Data Source: BioPlex
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999637131
p_ni: 0.00036256
p_wrong: 3.09e-7
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.99776999
p_ni: 0.002229812
p_wrong: 1.97e-7
Score: 0.179
Data Source: BioPlex,STRINGDB
CDK15
Tchem
Family: Kinase
Novelty: 0.3870338
p_int: 0.95367167
p_ni: 0.045429838
p_wrong: 0.000898492
Data Source: BioPlex
PTGDS
Tchem
Family: Enzyme
Novelty: 0.002111
p_int: 0.939966705
p_ni: 0.051834683
p_wrong: 0.008198613
Score: 0.587
Data Source: BioPlex,STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.987
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00112502
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  148.69

PubMed score by year
PubTator Score  163.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer