Tbio ORM1 Alpha-1-acid glycoprotein 1

Protein Summary

Description

Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02763
• B7ZKQ5
• Q5T539
• Q5U067
• Q8TC16
• AGP 1

Gene Name

• ORM1

Ensembl ID

• ENST00000259396
• ENSP00000259396
• ENSG00000229314

Symbol

• AGP1
• ORM
• AGP1
• AGP-A
• HEL-S-153w

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
cell type or tissue	0.76
chemical	0.67
biological term	0.65
disease	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.21   (req: < 5)

Gene RIFs: 84   (req: <= 3)

Antibodies: 567   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.21   (req: >= 5)

Gene RIFs: 84   (req: > 3)

Antibodies: 567   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0