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Tbio
AMBP
Protein AMBP

Protein Summary
Description
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. Trypstatin is a trypsin inhibitor. This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265132
  • ENSP00000265132
  • ENSG00000106927

Symbol
  • HCP
  • ITIL
  • A1M
  • HCP
  • ITI
  • UTI
  • EDC1
  • HI30
  • ITIL
  • IATIL
  • ITILC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.91
biological process
0.82
gene perturbation
0.77
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.35   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 523.35   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
AHSG
Tbio
Novelty:  0.00112502
Score:  0.979
Data Source:  STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.975
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.968
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.96
Data Source:  STRINGDB
ITIH2
Tbio
Novelty:  0.04886358
Score:  0.96
Data Source:  STRINGDB
APOH
Tbio
Novelty:  0.00049117
Score:  0.954
Data Source:  STRINGDB
FGB
Tbio
Novelty:  0.00437751
Score:  0.944
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.938
Data Source:  STRINGDB
IGLL5
Tbio
Novelty:  0.00459259
Score:  0.935
Data Source:  STRINGDB
IGLC1
Tdark
Novelty:  0.00459259
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging of heme from plasma
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
54.3
balding measurement
1
1
1
30.2
lifestyle measurement
1
1
1
27.3
Knee pain
1
2
2
27.3
serum metabolite measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
54.3
balding measurement
1
30.2
lifestyle measurement
1
27.3
Knee pain
2
27.3
serum metabolite measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88002
11699
Rat
RGD:2102
25377
Dog
alpha-1-microglobulin/bikunin precursor
VGNC:51697
481685
Horse
alpha-1-microglobulin/bikunin precursor
100051766
Cow
alpha-1-microglobulin/bikunin precursor
280996
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
alpha-1-microglobulin/bikunin precursor
Horse
alpha-1-microglobulin/bikunin precursor
Cow
alpha-1-microglobulin/bikunin precursor
Publication Statistics
PubMed Score 523.35
PubMed score by year
PubTator Score 517.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title