Tchem RBP4 Retinol-binding protein 4

Protein Summary

Description

Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02753
• D3DR38
• O43478
• O43479
• Q5VY24
• Q8WWA3
• Q9P178

Gene Name

• RBP4

Ensembl ID

• ENST00000371464
• ENSP00000360519
• ENSG00000138207
• ENST00000371467
• ENSP00000360522

Symbol

• RDCCAS
• MCOPCB10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
biological process	0.99
biological term	0.96
protein domain	0.92
PubMedID	0.82

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Retinol-binding Protein 4

DTO Classes

Protein / Transporter / Retinol-binding Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 711.82   (req: < 5)

Gene RIFs: 277   (req: <= 3)

Antibodies: 1291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 711.82   (req: >= 5)

Gene RIFs: 277   (req: > 3)

Antibodies: 1291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 270

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (3)

Explore Approved Drugs

1 – 3 of 3

retinol

RBP4Tchem

pKd : 6.74

retinol acetate

RBP4Tchem

pKd : 6.74

vitamin A palmitate

RBP4Tchem

pKd : 6.74

Active Ligands (270)

Explore Active Ligands

1 – 10 of 270

CHEMBL3359023

RBP4Tchem

pIC50 : 9.63

CHEMBL3359017

RBP4Tchem

pIC50 : 9.54

CHEMBL3359014

RBP4Tchem

pIC50 : 9.53

CHEMBL3359019

RBP4Tchem

pIC50 : 9.47

US9434727, 65

RBP4Tchem

pKi : 6.14

A1120

RBP4Tchem

pIC50 : 9.81

CHEMBL3359024

RBP4Tchem

pIC50 : 9.92

CHEMBL3359022

RBP4Tchem

pIC50 : 9.75

CHEMBL3359015

RBP4Tchem

pIC50 : 9.32

CHEMBL3359005

RBP4Tchem

pIC50 : 9.26

Protein-Protein Interactions (95)

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1 – 10 of 95

• See Interactions on String-DB

FTH1

Tbio

Novelty:  0.000863

p_int:  0.999997344

p_ni:  0.000002423

p_wrong:  2.33e-7

Score:  0.191

Data Source:  BioPlex,STRINGDB

MSRB3

Tbio

Family:  Enzyme

Novelty:  0.02843512

p_int:  0.999988428

p_ni:  0.000010758

p_wrong:  8.13e-7

Score:  0.201

Data Source:  BioPlex,STRINGDB

MARCKSL1

Tbio

Novelty:  0.01290798

p_int:  0.999981238

p_ni:  0.000018762

Score:  0.165

Data Source:  BioPlex,STRINGDB

CRYBA4

Tbio

Novelty:  0.03692663

p_int:  0.999599501

p_ni:  0.000398796

p_wrong:  0.000001703

Score:  0.161

Data Source:  BioPlex,STRINGDB

MTO1

Tbio

Novelty:  0.0229161

p_int:  0.999330185

p_ni:  0.000669815

Score:  0.179

Data Source:  BioPlex,STRINGDB

TMEM205

Tdark

Novelty:  0.41048198

p_int:  0.993232862

p_ni:  0.00518319

p_wrong:  0.001583948

Score:  0.187

Data Source:  BioPlex,STRINGDB

HESX1

Tbio

Family:  TF

Novelty:  0.00806405

p_int:  0.977421283

p_ni:  0.022578378

p_wrong:  3.39e-7

Score:  0.622

Data Source:  BioPlex,STRINGDB

POLR3D

Tbio

Family:  Enzyme

Novelty:  0.02616321

p_int:  0.959635908

p_ni:  0.040364092

Score:  0.181

Data Source:  BioPlex,STRINGDB

KLHL24

Tbio

Novelty:  0.04032749

p_int:  0.813721829

p_ni:  0.180688314

p_wrong:  0.005589857

Score:  0.189

Data Source:  BioPlex,STRINGDB

TTR

Tclin

Novelty:  0.0001199

Score:  0.998

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (29)

Reactome (15)

WikiPathways (14)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with visual transduction	13 targets	R-HSA-2474795
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases associated with visual transduction	13 targets	R-HSA-2474795
Diseases of signal transduction	387 targets	R-HSA-5663202
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (33)

Functions (4)

Components (5)

Processes (24)

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1 – 4 of 4

GO Term	Evidence	Assigned by
retinol binding	Inferred from Direct Assay (IDA)	BHF-UCL
retinol transmembrane transporter activity	Inferred by Curator (IC)	BHF-UCL
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
retinal binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (11)

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5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	3	5	6		82.8
waist-hip ratio	EFO_0004343	3	5	6		80.9
vitamin A measurement	EFO_0004857	1	1	1		62.8
waist circumference	EFO_0004342	1	1	1		56.4
BMI-adjusted waist circumference	EFO_0007789	1	1	1		42.3

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1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	6		82.8
waist-hip ratio	EFO_0004343	6		80.9
vitamin A measurement	EFO_0004857	1		62.8
waist circumference	EFO_0004342	1		56.4
BMI-adjusted waist circumference	EFO_0007789	1		42.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Methylation
Microphthalmia
Reference proteome
Retinol-binding
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
fasting blood glucose measurement
glucose measurement
high density lipoprotein cholesterol measurement
optic disc area measurement
reticulocyte count
triglyceride measurement
vitamin A measurement
waist circumference

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
muscle phenotype
reproductive system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	retinol binding protein 4	VGNC:5717	450617
Mouse	retinol binding protein 4, plasma	MGI:97879	19662
Rat	retinol binding protein 4	RGD:3546	25703
Dog	retinol binding protein 4	VGNC:45432	477775
Horse	retinol binding protein 4	VGNC:49533	100049790

Species	Name	OMA	EggNOG	Inparanoid
Chimp	retinol binding protein 4
Mouse	retinol binding protein 4, plasma
Rat	retinol binding protein 4
Dog	retinol binding protein 4
Horse	retinol binding protein 4

Publication Statistics

PubMed Score 711.82

PubMed score by year

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PubTator Score 1392.29

PubTator score by year

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Related Publications

Text Mined References (319)

GeneRif Annotations (277)

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PMID	Year	Title