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Tchem
RBP4
Retinol-binding protein 4

Protein Summary
Description
Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371464
  • ENSP00000360519
  • ENSG00000138207
  • ENST00000371467
  • ENSP00000360522

Symbol
  • RDCCAS
  • MCOPCB10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
biological process
0.99
biological term
0.96
protein domain
0.92
PubMedID
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.83   (req: < 5)
Gene RIFs: 277   (req: <= 3)
Antibodies: 1291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.83   (req: >= 5)
Gene RIFs: 277   (req: > 3)
Antibodies: 1291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 228
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc area measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc area measurement
1
5.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 4
VGNC:5717
450617
Mouse
MGI:97879
19662
Rat
RGD:3546
25703
Dog
retinol binding protein 4
VGNC:45432
477775
Horse
retinol binding protein 4
VGNC:49533
100049790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 4
Mouse
Rat
Dog
retinol binding protein 4
Horse
retinol binding protein 4
Protein Structure (22 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02753-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 22
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (95)
1 – 10 of 95
FTH1
Tbio
Novelty: 0.000863
p_int: 0.999997344
p_ni: 0.000002423
p_wrong: 2.33e-7
Score: 0.191
Data Source: BioPlex,STRINGDB
MSRB3
Tbio
Family: Enzyme
Novelty: 0.02843512
p_int: 0.999988428
p_ni: 0.000010758
p_wrong: 8.13e-7
Score: 0.201
Data Source: BioPlex,STRINGDB
MARCKSL1
Tbio
Novelty: 0.01290798
p_int: 0.999981238
p_ni: 0.000018762
Score: 0.165
Data Source: BioPlex,STRINGDB
CRYBA4
Tbio
Novelty: 0.03692663
p_int: 0.999599501
p_ni: 0.000398796
p_wrong: 0.000001703
Score: 0.161
Data Source: BioPlex,STRINGDB
MTO1
Tbio
Novelty: 0.0229161
p_int: 0.999330185
p_ni: 0.000669815
Score: 0.179
Data Source: BioPlex,STRINGDB
TMEM205
Tdark
Novelty: 0.41048198
p_int: 0.993232862
p_ni: 0.00518319
p_wrong: 0.001583948
Score: 0.187
Data Source: BioPlex,STRINGDB
HESX1
Tbio
Family: TF
Novelty: 0.00806405
p_int: 0.977421283
p_ni: 0.022578378
p_wrong: 3.39e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
POLR3D
Tbio
Family: Enzyme
Novelty: 0.02616321
p_int: 0.959635908
p_ni: 0.040364092
Score: 0.181
Data Source: BioPlex,STRINGDB
KLHL24
Tbio
Novelty: 0.04032749
p_int: 0.813721829
p_ni: 0.180688314
p_wrong: 0.005589857
Score: 0.189
Data Source: BioPlex,STRINGDB
TTR
Tclin
Novelty: 0.0001199
Score: 0.998
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  689.83

PubMed score by year
PubTator Score  1392.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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