Protein Summary
Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
- ENST00000371464
- ENSP00000360519
- ENSG00000138207
- ENST00000371467
- ENSP00000360522
- RDCCAS
- MCOPCB10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 1 | ||
biological process | 0.99 | ||
biological term | 0.96 | ||
protein domain | 0.92 | ||
PubMedID | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 711.82 (req: < 5)
Gene RIFs: 277 (req: <= 3)
Antibodies: 1291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 711.82 (req: >= 5)
Gene RIFs: 277 (req: > 3)
Antibodies: 1291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 270
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (270)
Protein-Protein Interactions (95)
FTH1
Novelty: 0.000863
p_int: 0.999997344
p_ni: 0.000002423
p_wrong: 2.33e-7
Score: 0.191
Data Source: BioPlex,STRINGDB
MSRB3
Family: Enzyme
Novelty: 0.02843512
p_int: 0.999988428
p_ni: 0.000010758
p_wrong: 8.13e-7
Score: 0.201
Data Source: BioPlex,STRINGDB
MARCKSL1
Novelty: 0.01290798
p_int: 0.999981238
p_ni: 0.000018762
Score: 0.165
Data Source: BioPlex,STRINGDB
CRYBA4
Novelty: 0.03692663
p_int: 0.999599501
p_ni: 0.000398796
p_wrong: 0.000001703
Score: 0.161
Data Source: BioPlex,STRINGDB
MTO1
Novelty: 0.0229161
p_int: 0.999330185
p_ni: 0.000669815
Score: 0.179
Data Source: BioPlex,STRINGDB
TMEM205
Novelty: 0.41048198
p_int: 0.993232862
p_ni: 0.00518319
p_wrong: 0.001583948
Score: 0.187
Data Source: BioPlex,STRINGDB
HESX1
Family: TF
Novelty: 0.00806405
p_int: 0.977421283
p_ni: 0.022578378
p_wrong: 3.39e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
POLR3D
Family: Enzyme
Novelty: 0.02616321
p_int: 0.959635908
p_ni: 0.040364092
Score: 0.181
Data Source: BioPlex,STRINGDB
KLHL24
Novelty: 0.04032749
p_int: 0.813721829
p_ni: 0.180688314
p_wrong: 0.005589857
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (29)
Reactome (15)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases associated with visual transduction | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Disease | ||||
Diseases associated with visual transduction | ||||
Diseases of signal transduction | ||||
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (4)
Components (5)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred by Curator (IC) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 3 | 5 | 6 | 82.8 | |||||
waist-hip ratio | 3 | 5 | 6 | 80.9 | |||||
vitamin A measurement | 1 | 1 | 1 | 62.8 | |||||
waist circumference | 1 | 1 | 1 | 56.4 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 6 | 82.8 | |||||
waist-hip ratio | 6 | 80.9 | |||||
vitamin A measurement | 1 | 62.8 | |||||
waist circumference | 1 | 56.4 | |||||
BMI-adjusted waist circumference | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | retinol binding protein 4 | VGNC:5717 | 450617 | |||||
Mouse | MGI:97879 | 19662 | ||||||
Rat | RGD:3546 | 25703 | ||||||
Dog | retinol binding protein 4 | VGNC:45432 | 477775 | |||||
Horse | retinol binding protein 4 | VGNC:49533 | 100049790 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | retinol binding protein 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | retinol binding protein 4 | |||||
Horse | retinol binding protein 4 | |||||
Publication Statistics
PubMed Score 711.82
PubMed score by year
PubTator Score 1392.29
PubTator score by year
Related Publications
Text Mined References (319)
GeneRif Annotations (277)
Items per page:
0 of 0
PMID | Year | Title |
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