Tchem RBP4 Retinol-binding protein 4

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Retinol-binding Protein 4

DTO Classes

Protein / Transporter / Retinol-binding Protein 4

Protein Summary

Description

Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496). This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02753
• D3DR38
• O43478
• O43479
• Q5VY24
• Q8WWA3
• Q9P178

Gene Name

• RBP4

Ensembl ID

• ENST00000371464
• ENSP00000360519
• ENSG00000138207
• ENST00000371467
• ENSP00000360522

Symbol

• RDCCAS
• MCOPCB10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
biological process	0.99
biological term	0.96
protein domain	0.92
PubMedID	0.82

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ARCHS4

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.83   (req: < 5)

Gene RIFs: 277   (req: <= 3)

Antibodies: 1291   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 689.83   (req: >= 5)

Gene RIFs: 277   (req: > 3)

Antibodies: 1291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 228

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Approved Drugs (3)

Explore Approved Drugs

1 – 3 of 3

retinol

RBP4Tchem

Kd : 6.74

retinol acetate

RBP4Tchem

Kd : 6.73999977

vitamin A palmitate

RBP4Tchem

Kd : 6.74

Active Ligands (228)

Explore Active Ligands

1 – 10 of 228

CHEMBL3288333

RBP4Tchem

IC50 : 6.04

CHEMBL3288141

RBP4Tchem

IC50 : 6.05

CHEMBL3892497

RBP4Tchem

IC50 : 6.83

CHEMBL3288334

RBP4Tchem

IC50 : 6.22

CHEMBL3288150

RBP4Tchem

IC50 : 6.08

CHEMBL3288338

RBP4Tchem

IC50 : 6.26

CHEMBL3593540

RBP4Tchem

IC50 : 7.29

CHEMBL3642673

RBP4Tchem

IC50 : 6.1

CHEMBL3914828

RBP4Tchem

IC50 : 6.37

CHEMBL3593693

RBP4Tchem

IC50 : 7.51

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
optic disc area measurement	EFO_0006937	1	1	1		5.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
optic disc area measurement	EFO_0006937	1		5.2

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	retinol binding protein 4	VGNC:5717	450617
Mouse	retinol binding protein 4, plasma	MGI:97879	19662
Rat	retinol binding protein 4	RGD:3546	25703
Dog	retinol binding protein 4	VGNC:45432	477775
Horse	retinol binding protein 4	VGNC:49533	100049790

Species	Name	OMA	EggNOG	Inparanoid
Chimp	retinol binding protein 4
Mouse	retinol binding protein 4, plasma
Rat	retinol binding protein 4
Dog	retinol binding protein 4
Horse	retinol binding protein 4

Protein Structure (22 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02753-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 22

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (29)

Reactome (15)

WikiPathways (14)

Disease (R-HSA-1643685)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases associated with visual transduction	13 targets	R-HSA-2474795
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
Diseases associated with visual transduction	13 targets	R-HSA-2474795
Diseases of signal transduction	387 targets	R-HSA-5663202
G alpha (i) signalling events	408 targets	R-HSA-418594
GPCR downstream signalling	1152 targets	R-HSA-388396

Gene Ontology Terms (33)

Functions (4)

Components (5)

Processes (24)

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1 – 4 of 4

GO Term	Evidence	Assigned by
retinol binding	Inferred from Direct Assay (IDA)	BHF-UCL
retinol transmembrane transporter activity	Inferred by Curator (IC)	BHF-UCL
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
retinal binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (95)

Explore Interacting Targets

1 – 10 of 95

• See Interactions on String-DB

FTH1

Tbio

Novelty: 0.000863

p_int: 0.999997344

p_ni: 0.000002423

p_wrong: 2.33e-7

Score: 0.191

Data Source: BioPlex,STRINGDB

MSRB3

Tbio

Family: Enzyme

Novelty: 0.02843512

p_int: 0.999988428

p_ni: 0.000010758

p_wrong: 8.13e-7

Score: 0.201

Data Source: BioPlex,STRINGDB

MARCKSL1

Tbio

Novelty: 0.01290798

p_int: 0.999981238

p_ni: 0.000018762

Score: 0.165

Data Source: BioPlex,STRINGDB

CRYBA4

Tbio

Novelty: 0.03692663

p_int: 0.999599501

p_ni: 0.000398796

p_wrong: 0.000001703

Score: 0.161

Data Source: BioPlex,STRINGDB

MTO1

Tbio

Novelty: 0.0229161

p_int: 0.999330185

p_ni: 0.000669815

Score: 0.179

Data Source: BioPlex,STRINGDB

TMEM205

Tdark

Novelty: 0.41048198

p_int: 0.993232862

p_ni: 0.00518319

p_wrong: 0.001583948

Score: 0.187

Data Source: BioPlex,STRINGDB

HESX1

Tbio

Family: TF

Novelty: 0.00806405

p_int: 0.977421283

p_ni: 0.022578378

p_wrong: 3.39e-7

Score: 0.622

Data Source: BioPlex,STRINGDB

POLR3D

Tbio

Family: Enzyme

Novelty: 0.02616321

p_int: 0.959635908

p_ni: 0.040364092

Score: 0.181

Data Source: BioPlex,STRINGDB

KLHL24

Tbio

Novelty: 0.04032749

p_int: 0.813721829

p_ni: 0.180688314

p_wrong: 0.005589857

Score: 0.189

Data Source: BioPlex,STRINGDB

TTR

Tclin

Novelty: 0.0001199

Score: 0.998

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  689.83

PubMed score by year

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PubTator Score  1392.29

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Methylation
Microphthalmia
Reference proteome
Retinol-binding
Secreted

GWAS Trait Find Similar Targets

optic disc area measurement

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
homeostasis/metabolism phenotype
muscle phenotype
reproductive system phenotype
vision/eye phenotype