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Tchem
FN1
Fibronectin

Protein Summary
Description
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323926
  • ENSP00000323534
  • ENSG00000115414
  • ENST00000336916
  • ENSP00000338200
  • ENST00000354785
  • ENSP00000346839
  • ENST00000356005
  • ENSP00000348285
  • ENST00000357867
  • ENSP00000350534
  • ENST00000359671
  • ENSP00000352696
  • ENST00000421182
  • ENSP00000394423
  • ENST00000426059
  • ENSP00000398907
  • ENST00000432072
  • ENSP00000399538
  • ENST00000443816
  • ENSP00000415018
  • ENST00000446046
  • ENSP00000410422

Symbol
  • FN
  • FN
  • CIG
  • FNZ
  • MSF
  • ED-B
  • FINC
  • GFND
  • LETS
  • GFND2
  • SMDCF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
transcription factor perturbation
1
disease perturbation
0.99
PubMedID
0.99
chemical
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27878.18   (req: < 5)
Gene RIFs: 517   (req: <= 3)
Antibodies: 2440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27878.18   (req: >= 5)
Gene RIFs: 517   (req: > 3)
Antibodies: 2440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0