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Tchem
FN1
Fibronectin

Protein Summary
Description
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts. Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323926
  • ENSP00000323534
  • ENSG00000115414
  • ENST00000336916
  • ENSP00000338200
  • ENST00000354785
  • ENSP00000346839
  • ENST00000356005
  • ENSP00000348285
  • ENST00000357867
  • ENSP00000350534
  • ENST00000359671
  • ENSP00000352696
  • ENST00000421182
  • ENSP00000394423
  • ENST00000426059
  • ENSP00000398907
  • ENST00000432072
  • ENSP00000399538
  • ENST00000443816
  • ENSP00000415018
  • ENST00000446046
  • ENSP00000410422

Symbol
  • FN
  • FN
  • CIG
  • FNZ
  • MSF
  • ED-B
  • FINC
  • GFND
  • LETS
  • GFND2
  • SMDCF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
transcription factor perturbation
1
disease perturbation
0.99
PubMedID
0.99
chemical
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25791.57   (req: < 5)
Gene RIFs: 416   (req: <= 3)
Antibodies: 2440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25791.57   (req: >= 5)
Gene RIFs: 416   (req: > 3)
Antibodies: 2440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
83.1
3
2
2
1.1
71.7
monocyte count
2
2
2
65.9
myeloid white cell count
1
1
1
48.3
1
1
0
1.2
30.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
83.1
2
1.1
71.7
monocyte count
2
65.9
myeloid white cell count
1
48.3
0
1.2
30.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin 1
VGNC:433
459926
Macaque
fibronectin 1
613269
Mouse
MGI:95566
14268
Rat
RGD:2624
25661
Dog
fibronectin 1
403845
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin 1
Macaque
fibronectin 1
Mouse
Rat
Dog
fibronectin 1
Protein Data Bank (57)
1 – 5 of 57
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (79)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Extracellular matrix organization
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (1022)
1 – 10 of 1022
TGM2
Tchem
Family: Enzyme
Novelty: 0.0005293
p_int: 0.999995834
p_ni: 0.000004166
Score: 0.878
Data Source: BioPlex,STRINGDB
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.999982824
p_ni: 0.000017176
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999982216
p_ni: 0.000017784
Score: 0.686
Data Source: BioPlex,STRINGDB
ECM1
Tbio
Novelty: 0.00518679
p_int: 0.999959493
p_ni: 0.000040507
Score: 0.479
Data Source: BioPlex,STRINGDB
COLQ
Tbio
Family: Enzyme
Novelty: 0.01414634
p_int: 0.999942337
p_ni: 0.000057663
Score: 0.17
Data Source: BioPlex,STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
p_int: 0.999921617
p_ni: 0.000078383
Score: 0.605
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.999877004
p_ni: 0.000122996
Score: 0.293
Data Source: BioPlex,STRINGDB
ZKSCAN4
Tbio
Family: TF
Novelty: 0.33154485
p_int: 0.99981557
p_ni: 0.00018443
Data Source: BioPlex
MMP9
Tchem
Family: Enzyme
Novelty: 0.00008645
p_int: 0.999634344
p_ni: 0.000365656
Score: 0.599
Data Source: BioPlex,STRINGDB
MEPE
Tbio
Novelty: 0.00825085
p_int: 0.999522212
p_ni: 0.000477788
Score: 0.928
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  25791.57

PubMed score by year
PubTator Score  13235.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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