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Tbio
LRG1
Leucine-rich alpha-2-glycoprotein

Protein Summary
Description
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation (O'Donnell et al., 2002 [PubMed 12223515]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306390
  • ENSP00000302621
  • ENSG00000171236

Symbol
  • LRG
  • LRG
  • HMFT1766
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.79
gene perturbation
0.76
disease
0.67
transcription factor perturbation
0.54
tissue
0.53


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.34   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 387   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.34   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 387   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich alpha-2-glycoprotein 1
VGNC:8753
738488
Macaque
leucine rich alpha-2-glycoprotein 1
693859
Mouse
MGI:1924155
76905
Rat
RGD:1359464
367455
Dog
leucine rich alpha-2-glycoprotein 1
VGNC:42765
611876
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich alpha-2-glycoprotein 1
Macaque
leucine rich alpha-2-glycoprotein 1
Mouse
Rat
Dog
leucine rich alpha-2-glycoprotein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P02750-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (133)
1 – 10 of 133
CYCS
Tchem
Novelty: 0.00014004
p_int: 0.998752099
p_ni: 0.001247901
Score: 0.862
Data Source: BioPlex,STRINGDB
NME2
Tbio
Family: Kinase
Novelty: 0.00257937
p_int: 0.952809893
p_ni: 0.047190106
p_wrong: 2e-9
Data Source: BioPlex
HP
Tbio
Novelty: 0.00016649
Score: 0.959
Data Source: STRINGDB
ORM1
Tbio
Novelty: 0.007451
Score: 0.937
Data Source: STRINGDB
ORM2
Tbio
Novelty: 0.00837073
Score: 0.928
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.927
Data Source: STRINGDB
SLPI
Tbio
Family: Enzyme
Novelty: 0.00194459
Score: 0.918
Data Source: STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.917
Data Source: STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.916
Data Source: STRINGDB
OLFM4
Tbio
Novelty: 0.01048505
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score  257.34

PubMed score by year
PubTator Score  97.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer