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Tbio
C9
Complement component C9

Protein Summary
Description
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:9634479, PubMed:9212048, PubMed:26841934). C9 is the pore-forming subunit of the MAC (PubMed:4055801, PubMed:26841934). This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263408
  • ENSP00000263408
  • ENSG00000113600

Symbol
  • C9D
  • ARMD15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.89
cell line
0.71
cell type or tissue
0.62
disease
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.81   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 478   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.81   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 478   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
6
5
7
94.6
heel bone mineral density
2
1
3
92.8
creatinine measurement
4
3
4
87
atrophic macular degeneration
1
1
0
1.8
72.9
1
1
0
1.8
72.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
94.6
heel bone mineral density
3
92.8
creatinine measurement
4
87
atrophic macular degeneration
0
1.8
72.9
0
1.8
72.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C9
VGNC:3925
100610175
Macaque
complement C9
694223
Mouse
MGI:1098282
12279
Rat
RGD:620319
117512
Dog
complement C9
VGNC:38603
479354
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C9
Macaque
complement C9
Mouse
Rat
Dog
complement C9
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02748-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Reactome
Terminal pathway of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Terminal pathway of complement
Gene Ontology Terms (15)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (84)
1 – 10 of 84
APOE
Tbio
Novelty: 0.00005049
p_int: 0.999854944
p_ni: 0.000144993
p_wrong: 6.3e-8
Score: 0.401
Data Source: BioPlex,STRINGDB
CST6
Tbio
Novelty: 0.02811473
p_int: 0.875974003
p_ni: 0.122121429
p_wrong: 0.001904568
Score: 0.187
Data Source: BioPlex,STRINGDB
CLU
Tbio
Novelty: 0.00054776
Score: 0.963
Data Source: Reactome,STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.961
Data Source: Reactome,STRINGDB
C8A
Tbio
Novelty: 0.00429321
Score: 0.96
Data Source: Reactome,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
Score: 0.957
Data Source: Reactome,STRINGDB
C8B
Tbio
Novelty: 0.00873524
Score: 0.956
Data Source: Reactome,STRINGDB
C5
Tclin
Novelty: 0.00225386
Score: 0.954
Data Source: Reactome,STRINGDB
C8G
Tbio
Novelty: 0.02322575
Score: 0.939
Data Source: Reactome,STRINGDB
FGB
Tbio
Novelty: 0.00437751
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.81

PubMed score by year
PubTator Score  417.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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