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Tbio
C1QC
Complement C1q subcomponent subunit C

Protein Summary
Description
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. This gene encodes the C-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374637
  • ENSP00000363768
  • ENSG00000159189
  • ENST00000374639
  • ENSP00000363770
  • ENST00000374640
  • ENSP00000363771

Symbol
  • C1QG
  • C1QG
  • C1Q-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
drug
0.79
gene perturbation
0.76
tissue sample
0.6
biological term
0.55


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1q C chain
VGNC:12982
456612
Macaque
complement C1q C chain
708589
Mouse
MGI:88225
12262
Rat
RGD:1306828
362634
Dog
complement C1q C chain
VGNC:52112
487382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1q C chain
Macaque
complement C1q C chain
Mouse
Rat
Dog
complement C1q C chain
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (119)
1 – 10 of 119
C1QB
Tbio
Novelty: 0.01476497
Score: 0.999
Data Source: Reactome,STRINGDB
C1QA
Tbio
Novelty: 0.00987917
Score: 0.997
Data Source: Reactome,STRINGDB
C1S
Tchem
Novelty: 0.00043003
Score: 0.97
Data Source: Reactome,STRINGDB
C1R
Tclin
Novelty: 0.00210654
Score: 0.968
Data Source: Reactome,STRINGDB
SERPING1
Tbio
Family: Enzyme
Novelty: 0.00068448
Score: 0.961
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.959
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.959
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.00974862
Score: 0.937
Data Source: Reactome,STRINGDB
CRP
Tbio
Novelty: 0.00001517
Score: 0.92
Data Source: Reactome,STRINGDB
IGLL5
Tbio
Novelty: 0.00459259
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.26

PubMed score by year
PubTator Score  16.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer