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Tbio
C1QB
Complement C1q subcomponent subunit B

Protein Summary
Description
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. This gene encodes the B-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314933
  • ENSP00000313967
  • ENSG00000173369
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
disease perturbation
0.93
drug
0.79
small molecule perturbation
0.68
gene perturbation
0.6


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.5   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.5   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88224
12260
Rat
RGD:2229
29687
Dog
complement C1q B chain
VGNC:38577
487381
Horse
complement C1q B chain
VGNC:15937
100071667
Cow
complement C1q B chain
VGNC:26617
617435
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
complement C1q B chain
Horse
complement C1q B chain
Cow
complement C1q B chain
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02746-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Protein-Protein Interactions (155)
1 – 10 of 155
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.985555034
p_ni: 0.014329006
p_wrong: 0.00011596
Score: 0.183
Data Source: BioPlex,STRINGDB
FN1
Tchem
Novelty: 0.00003647
p_int: 0.983738276
p_ni: 0.016261724
Score: 0.524
Data Source: BioPlex,STRINGDB
USP30
Tbio
Family: Enzyme
Novelty: 0.03427211
p_int: 0.976817374
p_ni: 0.023182626
Score: 0.21
Data Source: BioPlex,STRINGDB
METAP2
Tchem
Family: Enzyme
Novelty: 0.00570955
p_int: 0.949313298
p_ni: 0.050686702
Data Source: BioPlex
P3H3
Tbio
Family: Enzyme
Novelty: 0.0010004
p_int: 0.90418425
p_ni: 0.095815673
p_wrong: 7.7e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
NOCT
Tbio
Novelty: 0.01696096
p_int: 0.872077016
p_ni: 0.127865969
p_wrong: 0.000057014
Score: 0.163
Data Source: BioPlex,STRINGDB
ATP12A
Tchem
Family: Transporter
Novelty: 0.00008793
p_int: 0.79751186
p_ni: 0.20248814
Data Source: BioPlex
DMWD
Tbio
Novelty: 0.04096001
p_int: 0.78888045
p_ni: 0.208760334
p_wrong: 0.002359216
Score: 0.169
Data Source: BioPlex,STRINGDB
C1QA
Tbio
Novelty: 0.00987917
Score: 0.999
Data Source: Reactome,STRINGDB
C1QC
Tbio
Novelty: 0.0286777
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  60.50

PubMed score by year
PubTator Score  34.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer