Protein Summary
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
- ENST00000255040
- ENSP00000255040
- ENSG00000132703
- PTX2
- SAP
- PTX2
- HEL-S-92n
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.82 | ||
cell type or tissue | 0.7 | ||
biological term | 0.69 | ||
gene perturbation | 0.66 | ||
cellular component | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 580.05 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 578 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 580.05 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 578 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (102)
Nearest Tclin Targets
Pathways (3)
Reactome (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (7)
Components (6)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 5 | 19 | 21 | 99.6 | |||||
granulocyte count | 1 | 3 | 3 | 81.5 | |||||
CCL2 measurement | 2 | 2 | 2 | 79.3 | |||||
leukocyte count | 2 | 1 | 2 | 40.7 | |||||
eotaxin measurement | 1 | 1 | 1 | 8.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 21 | 99.6 | |||||
granulocyte count | 3 | 81.5 | |||||
CCL2 measurement | 2 | 79.3 | |||||
leukocyte count | 2 | 40.7 | |||||
eotaxin measurement | 1 | 8.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | amyloid P component, serum | VGNC:89 | 457427 | |||||
Macaque | amyloid P component, serum | 719421 | ||||||
Mouse | MGI:98229 | 20219 | ||||||
Rat | RGD:68322 | 29339 | ||||||
Horse | amyloid P component, serum | VGNC:15402 | 100053475 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | amyloid P component, serum | |||||
Macaque | amyloid P component, serum | |||||
Mouse | ||||||
Rat | ||||||
Horse | amyloid P component, serum | |||||
Publication Statistics
PubMed Score 580.05
PubMed score by year
PubTator Score 671.93
PubTator score by year
Related Publications
Text Mined References (97)
GeneRif Annotations (53)
Items per page:
0 of 0
PMID | Year | Title |
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