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Tchem
APCS
Serum amyloid P-component

Protein Summary
Description
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255040
  • ENSP00000255040
  • ENSG00000132703

Symbol
  • PTX2
  • SAP
  • PTX2
  • HEL-S-92n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
cell type or tissue
0.7
biological term
0.69
gene perturbation
0.66
cellular component
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.05   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 580.05   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (102)
TTR
Tclin
Novelty:  0.0001199
Score:  0.967
Data Source:  STRINGDB
SAA1
Tbio
Novelty:  0.0006102
Score:  0.957
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.952
Data Source:  STRINGDB
FGA
Tbio
Novelty:  0.00107227
Score:  0.945
Data Source:  STRINGDB
APOA4
Tbio
Novelty:  0.00305835
Score:  0.945
Data Source:  STRINGDB
GSN
Tbio
Novelty:  0.00060852
Score:  0.943
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.935
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.932
Data Source:  STRINGDB
IAPP
Tbio
Novelty:  0.0005195
Score:  0.932
Data Source:  STRINGDB
APP
Tchem
Novelty:  0.00008964
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
19
21
99.6
granulocyte count
1
3
3
81.5
CCL2 measurement
2
2
2
79.3
leukocyte count
2
1
2
40.7
eotaxin measurement
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
21
99.6
granulocyte count
3
81.5
CCL2 measurement
2
79.3
leukocyte count
2
40.7
eotaxin measurement
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amyloid P component, serum
VGNC:89
457427
Macaque
amyloid P component, serum
719421
Mouse
MGI:98229
20219
Rat
RGD:68322
29339
Horse
amyloid P component, serum
VGNC:15402
100053475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amyloid P component, serum
Macaque
amyloid P component, serum
Mouse
Rat
Horse
amyloid P component, serum
Publication Statistics
PubMed Score 580.05
PubMed score by year
PubTator Score 671.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title