Protein Summary
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo. [provided by RefSeq, Sep 2008]
- ENST00000255040
- ENSP00000255040
- ENSG00000132703
- PTX2
- SAP
- PTX2
- HEL-S-92n
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.82 | ||
cell type or tissue | 0.7 | ||
biological term | 0.69 | ||
gene perturbation | 0.66 | ||
cellular component | 0.65 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.87 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 578 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.87 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 578 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 1 | 1 | 1 | 64.4 | |||||
mathematical ability | 1 | 1 | 1 | 10.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 1 | 64.4 | |||||
mathematical ability | 1 | 10.4 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | amyloid P component, serum | VGNC:89 | 457427 | |||||
Macaque | amyloid P component, serum | 719421 | ||||||
Mouse | MGI:98229 | 20219 | ||||||
Rat | RGD:68322 | 29339 | ||||||
Horse | amyloid P component, serum | VGNC:15402 | 100053475 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | amyloid P component, serum | |||||
Macaque | amyloid P component, serum | |||||
Mouse | ||||||
Rat | ||||||
Horse | amyloid P component, serum | |||||
Protein Structure (13 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 13
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (3)
Reactome (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Amyloid fiber formation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Amyloid fiber formation | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (28)
Functions (7)
Components (6)
Processes (15)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (102)
1 – 10 of 102
TTR
Novelty: 0.0001199
Score: 0.967
Data Source: STRINGDB
SAA1
Novelty: 0.0006102
Score: 0.957
Data Source: STRINGDB
APOA1
Novelty: 0.0001216
Score: 0.952
Data Source: STRINGDB
FGA
Novelty: 0.00107227
Score: 0.945
Data Source: STRINGDB
APOA4
Novelty: 0.00305835
Score: 0.945
Data Source: STRINGDB
GSN
Novelty: 0.00060852
Score: 0.943
Data Source: STRINGDB
HIST2H2AC
Novelty: 0.00065524
Score: 0.935
Data Source: STRINGDB
B2M
Novelty: 0.00011248
Score: 0.932
Data Source: STRINGDB
IAPP
Novelty: 0.0005195
Score: 0.932
Data Source: STRINGDB
APP
Novelty: 0.00008964
Score: 0.931
Data Source: STRINGDB
Publication Statistics
PubMed Score 561.87
PubMed score by year
PubTator Score 671.93
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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