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Tbio
SLC4A1
Band 3 anion transport protein

Protein Summary
Description
Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262418
  • ENSP00000262418
  • ENSG00000004939

Symbol
  • AE1
  • DI
  • EPB3
  • DI
  • FR
  • SW
  • WD
  • WR
  • AE1
  • CHC
  • SAO
  • WD1
  • BND3
  • EPB3
  • SPH4
  • CD233
  • EMPB3
  • RTA1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.92
molecular function
0.86
disease perturbation
0.74
kinase
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.3   (req: < 5)
Gene RIFs: 180   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.3   (req: >= 5)
Gene RIFs: 180   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
EPB42
Tbio
Family:  Enzyme
Novelty:  0.06393286
Score:  0.939
Data Source:  STRINGDB
ALAS2
Tbio
Family:  Enzyme
Novelty:  0.00491418
Score:  0.905
Data Source:  STRINGDB
GYPA
Tbio
Novelty:  0.00067203
Score:  0.873
Data Source:  STRINGDB
AHSP
Tbio
Novelty:  0.00996928
Score:  0.866
Data Source:  STRINGDB
EPB41
Tbio
Novelty:  0.0013288
Score:  0.845
Data Source:  STRINGDB
GYPB
Tbio
Novelty:  0.00442195
Score:  0.834
Data Source:  STRINGDB
ANK1
Tbio
Novelty:  0.00225305
Score:  0.827
Data Source:  STRINGDB
CA1
Tclin
Family:  Enzyme
Novelty:  0.00055482
Score:  0.805
Data Source:  STRINGDB
HBD
Tbio
Novelty:  0.00203187
Score:  0.748
Data Source:  STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
Score:  0.737
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)
Disease
Disorders of transmembrane transporters
Erythrocytes take up carbon dioxide and release oxygen
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
2
2
94.3
red blood cell distribution width
4
2
4
91.9
reticulocyte count
6
6
9
91
mean corpuscular volume
2
4
4
90.1
reticulocyte measurement
3
4
6
89.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
94.3
red blood cell distribution width
4
91.9
reticulocyte count
9
91
mean corpuscular volume
4
90.1
reticulocyte measurement
6
89.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 1
VGNC:9624
454727
Macaque
solute carrier family 4 member 1 (Diego blood group)
100427618
Mouse
MGI:109393
20533
Rat
RGD:3710
24779
Dog
solute carrier family 4 member 1
VGNC:49095
490939
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 1
Macaque
solute carrier family 4 member 1 (Diego blood group)
Mouse
Rat
Dog
solute carrier family 4 member 1
Publication Statistics
PubMed Score 436.30
PubMed score by year
PubTator Score 1295.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title