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Tbio
GYPA
Glycophorin-A

Protein Summary
Description
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isofor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324022
  • ENSP00000324483
  • ENSG00000170180
  • ENST00000642713
  • ENSP00000494092
  • ENST00000646447
  • ENSP00000495922

Symbol
  • GPA
  • MN
  • GPA
  • MNS
  • GPSAT
  • PAS-2
  • CD235a
  • GPErik
  • HGpMiV
  • HGpMiXI
  • HGpSta(C)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.76
cellular component
0.62
disease
0.59
microRNA
0.59
chemical
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1419.69   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 1867   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1419.69   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 1867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
86.9
mean corpuscular hemoglobin concentration
1
1
1
82.1
mean reticulocyte volume
1
2
2
58.7
platelet crit
2
2
2
52.9
mean corpuscular volume
1
1
1
47
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
86.9
mean corpuscular hemoglobin concentration
1
82.1
mean reticulocyte volume
2
58.7
platelet crit
2
52.9
mean corpuscular volume
1
47
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycophorin A (MNS blood group)
461520
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycophorin A (MNS blood group)
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02724-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (101)
1 – 10 of 101
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
p_int: 0.999972958
p_ni: 0.000027042
Data Source: BioPlex
CLDND1
Tbio
Novelty: 0.06681793
p_int: 0.999373195
p_ni: 0.000542726
p_wrong: 0.000084079
Score: 0.392
Data Source: BioPlex,STRINGDB
TMEM192
Tbio
Novelty: 0.30699087
p_int: 0.995918615
p_ni: 0.004081384
Score: 0.183
Data Source: BioPlex,STRINGDB
GOLGA7
Tbio
Novelty: 0.17108842
p_int: 0.995696641
p_ni: 0.004267111
p_wrong: 0.000036248
Score: 0.686
Data Source: BioPlex,STRINGDB
TCAF2
Tbio
Family: Enzyme
Novelty: 0.37070492
p_int: 0.993668862
p_ni: 0.006329421
p_wrong: 0.000001716
Data Source: BioPlex
EEF1A2
Tchem
Novelty: 0.001472
p_int: 0.943121942
p_ni: 0.056878058
Data Source: BioPlex
SLC22A18
Tbio
Family: Transporter
Novelty: 0.0189809
p_int: 0.914290946
p_ni: 0.085708986
p_wrong: 6.8e-8
Data Source: BioPlex
STAT2
Tbio
Family: TF
Novelty: 0.00241454
p_int: 0.840693727
p_ni: 0.147736785
p_wrong: 0.011569489
Score: 0.189
Data Source: BioPlex,STRINGDB
DNM3
Tbio
Novelty: 0.02365643
p_int: 0.832405476
p_ni: 0.167594524
Data Source: BioPlex
NEMF
Tbio
Novelty: 0.05052246
p_int: 0.831005906
p_ni: 0.168994094
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1419.69

PubMed score by year
PubTator Score  1076.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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