CHRNA1
Acetylcholine receptor subunit alpha
Protein Summary
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]
- ENST00000261007
- ENSP00000261007
- ENSG00000138435
- ENST00000348749
- ENSP00000261008
- ACHRA
- CHNRA
- ACHRA
- ACHRD
- CHRNA
- CMS1A
- CMS1B
- CMS2A
- FCCMS
- SCCMS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
protein domain | 0.85 | ||
phenotype | 0.65 | ||
tissue | 0.61 | ||
disease | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.52 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 396 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.52 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 396 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 15