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Tclin
CHRNA1
Acetylcholine receptor subunit alpha

Protein Classes
Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261007
  • ENSP00000261007
  • ENSG00000138435
  • ENST00000348749
  • ENSP00000261008

Symbol
  • ACHRA
  • CHNRA
  • ACHRA
  • ACHRD
  • CHRNA
  • CMS1A
  • CMS1B
  • CMS2A
  • FCCMS
  • SCCMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.85
phenotype
0.65
tissue
0.61
disease
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.42   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 396   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.42   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 396   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 15
Approved Drugs (15)
1 – 10 of 15
tubocurarine
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decamethonium
Rendered image for decamethonium
mecamylamine
Rendered image for mecamylamine
suxamethonium
Rendered image for suxamethonium
rapacuronium
Rendered image for rapacuronium
atracurium
Rendered image for atracurium
cisatracurium
Rendered image for cisatracurium
dimethyltubocurarinium
Rendered image for dimethyltubocurarinium
mivacurium
Rendered image for mivacurium
pancuronium
Rendered image for pancuronium
Active Ligands (10)
1 – 10 of 10
epibatidine
Rendered image for epibatidine
CHEMBL1210703
Rendered image for CHEMBL1210703
CHEMBL1210515
Rendered image for CHEMBL1210515
CHEMBL2022495
Rendered image for CHEMBL2022495
CHEMBL2022739
Rendered image for CHEMBL2022739
CHEMBL1823380
Rendered image for CHEMBL1823380
CHEMBL1823381
Rendered image for CHEMBL1823381
CHEMBL1823382
Rendered image for CHEMBL1823382
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
24.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 1 subunit
VGNC:136
470583
Macaque
cholinergic receptor nicotinic alpha 1 subunit
698578
Mouse
MGI:87885
11435
Rat
RGD:69277
79557
Dog
cholinergic receptor nicotinic alpha 1 subunit
VGNC:39236
403757
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic alpha 1 subunit
Macaque
cholinergic receptor nicotinic alpha 1 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic alpha 1 subunit
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02708-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Gene Ontology Terms (31)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO
Inferred from Mutant Phenotype (IMP)
MGI
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (97)
1 – 10 of 97
RAPSN
Tbio
Novelty:  0.00565077
Score:  0.974
Data Source:  STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.942
Data Source:  STRINGDB
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
Score:  0.927
Data Source:  STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
Score:  0.923
Data Source:  STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.922
Data Source:  STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.921
Data Source:  STRINGDB
UTRN
Tchem
Novelty:  0.0018541
Score:  0.921
Data Source:  STRINGDB
DMD
Tclin
Novelty:  0.00025661
Score:  0.921
Data Source:  STRINGDB
CHRM1
Tclin
Family:  GPCR
Novelty:  0.00427119
Score:  0.919
Data Source:  STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
Score:  0.909
Data Source:  STRINGDB
Publication Statistics
PubMed Score  61.42

PubMed score by year
PubTator Score  89.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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