Protein Summary
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in ...more
- ENST00000355994
- ENSP00000348273
- ENSG00000197971
- ENST00000359645
- ENSP00000352667
- ENST00000382582
- ENSP00000372025
- ENST00000397860
- ENSP00000380958
- ENST00000397863
- ENSP00000380961
- ENST00000397865
- ENSP00000380963
- ENST00000397866
- ENSP00000380964
- ENST00000580402
- ENSP00000462223
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phosphatase | 1 | ||
transcription factor perturbation | 0.99 | ||
hub protein | 0.97 | ||
PubMedID | 0.97 | ||
disease perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6413.96 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 1187 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6413.96 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 1187 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (239)
CTDSPL
Family: Enzyme
Novelty: 0.00471423
p_int: 0.999772849
p_ni: 0.000227111
p_wrong: 3.9e-8
Score: 0.933
Data Source: BioPlex,STRINGDB
CTDSP1
Family: Enzyme
Novelty: 0.0231786
p_int: 0.999740521
p_ni: 0.00023558
p_wrong: 0.000023899
Score: 0.812
Data Source: BioPlex,STRINGDB
NLN
Family: Enzyme
Novelty: 0.01217367
p_int: 0.973146809
p_ni: 0.026853139
p_wrong: 5.3e-8
Score: 0.282
Data Source: BioPlex,STRINGDB
IDE
Family: Enzyme
Novelty: 0.00207793
p_int: 0.893052127
p_ni: 0.106947873
Score: 0.287
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
WikiPathways (7)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Spinal Cord Injury | ||||
WikiPathways | Glial Cell Differentiation | ||||
WikiPathways | MECP2 and Associated Rett Syndrome | ||||
WikiPathways | Neural Crest Differentiation | ||||
WikiPathways | Structural Pathway of Interleukin 1 (IL-1) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Spinal Cord Injury | ||||
Glial Cell Differentiation | ||||
MECP2 and Associated Rett Syndrome | ||||
Neural Crest Differentiation | ||||
Structural Pathway of Interleukin 1 (IL-1) | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (10)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myelin basic protein | VGNC:5183 | 455522 | |||||
Macaque | myelin basic protein | 710350 | ||||||
Mouse | MGI:96925 | 17196 | ||||||
Rat | RGD:3054 | 24547 | ||||||
Dog | myelin basic protein | VGNC:53736 | 476160 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myelin basic protein | |||||
Macaque | myelin basic protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | myelin basic protein | |||||
Publication Statistics
PubMed Score 6413.96
PubMed score by year
PubTator Score 4452.05
PubTator score by year
Related Publications
Text Mined References (145)
GeneRif Annotations (70)
Items per page:
0 of 0
PMID | Year | Title |
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