Tbio MBP Myelin basic protein

Protein Summary

Description

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02686
• A4FU54
• A6NI84
• A8MY86
• A8MYL4
• B3KY66
• B7ZKS2
• B7ZKS4
• Q15337
• Q15338
• Q15339
• Q15340
• Q59GX3
• Q65ZS4
• Q6AI64
• Q6FH37
• Q6FI04
• Q6PK23
• MBP

Gene Name

• MBP

Ensembl ID

• ENST00000355994
• ENSP00000348273
• ENSG00000197971
• ENST00000359645
• ENSP00000352667
• ENST00000382582
• ENSP00000372025
• ENST00000397860
• ENSP00000380958
• ENST00000397863
• ENSP00000380961
• ENST00000397865
• ENSP00000380963
• ENST00000397866
• ENSP00000380964
• ENST00000580402
• ENSP00000462223

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phosphatase	1
transcription factor perturbation	0.99
hub protein	0.97
PubMedID	0.97
disease perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6734.67   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 1187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6734.67   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 1187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (239)

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1 – 10 of 239

• See Interactions on String-DB

CTDSPL

Tbio

Family:  Enzyme

Novelty:  0.00471423

p_int:  0.999772849

p_ni:  0.000227111

p_wrong:  3.9e-8

Score:  0.933

Data Source:  BioPlex,STRINGDB

CTDSP1

Tchem

Family:  Enzyme

Novelty:  0.0231786

p_int:  0.999740521

p_ni:  0.00023558

p_wrong:  0.000023899

Score:  0.812

Data Source:  BioPlex,STRINGDB

NLN

Tbio

Family:  Enzyme

Novelty:  0.01217367

p_int:  0.973146809

p_ni:  0.026853139

p_wrong:  5.3e-8

Score:  0.282

Data Source:  BioPlex,STRINGDB

IDE

Tchem

Family:  Enzyme

Novelty:  0.00207793

p_int:  0.893052127

p_ni:  0.106947873

Score:  0.287

Data Source:  BioPlex,STRINGDB

MAG

Tchem

Novelty:  0.00085621

Score:  0.944

Data Source:  STRINGDB

PLP1

Tbio

Novelty:  0.00129083

Score:  0.915

Data Source:  STRINGDB

MOG

Tbio

Novelty:  0.00048664

Score:  0.907

Data Source:  STRINGDB

MOK

Tbio

Family:  Kinase

Novelty:  0.0116106

Score:  0.901

Data Source:  STRINGDB

MAPK1

Tchem

Family:  Kinase

Novelty:  0.00061058

Score:  0.848

Data Source:  STRINGDB

GFAP

Tbio

Novelty:  0.00020932

Score:  0.844

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

WikiPathways (7)

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Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Spinal Cord Injury	164 targets	WP2431_r105820
WikiPathways	Glial Cell Differentiation	10 targets	WP2276_r105608
WikiPathways	MECP2 and Associated Rett Syndrome	162 targets	WP3584_r105641
WikiPathways	Neural Crest Differentiation	262 targets	WP2064_r105663
WikiPathways	Structural Pathway of Interleukin 1 (IL-1)	534 targets	WP2637_r105827

Name	Explore in Pharos	Explore in Source
Spinal Cord Injury	164 targets	WP2431_r105820
Glial Cell Differentiation	10 targets	WP2276_r105608
MECP2 and Associated Rett Syndrome	162 targets	WP3584_r105641
Neural Crest Differentiation	262 targets	WP2064_r105663
Structural Pathway of Interleukin 1 (IL-1)	534 targets	WP2637_r105827

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (3)

Components (10)

Processes (15)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
calmodulin binding	Inferred from Physical Interaction (IPI)	CAFA
structural constituent of myelin sheath	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protease binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neuroimaging measurement	EFO_0004346	3	2	3		60.9
appendicular lean mass	EFO_0004980	1	1	1		58.7
lymphocyte count	EFO_0004587	2	2	2		44
body height	EFO_0004339	1	1	1		40.1
educational attainment	EFO_0011015	1	2	2		39.4

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neuroimaging measurement	EFO_0004346	3		60.9
appendicular lean mass	EFO_0004980	1		58.7
lymphocyte count	EFO_0004587	2		44
body height	EFO_0004339	1		40.1
educational attainment	EFO_0011015	2		39.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Autoimmune encephalomyelitis
Cell membrane
Citrullination
Complete proteome
Direct protein sequencing
Membrane
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
body height
educational attainment
employment status
hemoglobin A1 measurement
lymphocyte count
neuroimaging measurement
thoracic aortic aneurysm

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	myelin basic protein	VGNC:5183	455522
Macaque	myelin basic protein		710350
Mouse	myelin basic protein	MGI:96925	17196
Rat	myelin basic protein	RGD:3054	24547
Dog	myelin basic protein	VGNC:53736	476160

Species	Name	OMA	EggNOG	Inparanoid
Chimp	myelin basic protein
Macaque	myelin basic protein
Mouse	myelin basic protein
Rat	myelin basic protein
Dog	myelin basic protein

Publication Statistics

PubMed Score 6734.67

PubMed score by year

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PubTator Score 4452.05

PubTator score by year

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Related Publications

Text Mined References (145)

GeneRif Annotations (70)

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PMID	Year	Title