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Tbio
MBP
Myelin basic protein

Protein Summary
Description
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355994
  • ENSP00000348273
  • ENSG00000197971
  • ENST00000359645
  • ENSP00000352667
  • ENST00000382582
  • ENSP00000372025
  • ENST00000397860
  • ENSP00000380958
  • ENST00000397863
  • ENSP00000380961
  • ENST00000397865
  • ENSP00000380963
  • ENST00000397866
  • ENSP00000380964
  • ENST00000580402
  • ENSP00000462223
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phosphatase
1
transcription factor perturbation
0.99
hub protein
0.97
PubMedID
0.97
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6364.87   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 1187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6364.87   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 1187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
50.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
50.8
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Spinal Cord Injury
WikiPathways
Glial Cell Differentiation
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
Neural Crest Differentiation
WikiPathways
Structural Pathway of Interleukin 1 (IL-1)
Name
Explore in Pharos
Explore in Source
Spinal Cord Injury
Glial Cell Differentiation
MECP2 and Associated Rett Syndrome
Neural Crest Differentiation
Structural Pathway of Interleukin 1 (IL-1)
Gene Ontology Terms (28)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (239)
1 – 10 of 239
CTDSPL
Tbio
Family: Enzyme
Novelty: 0.00471423
p_int: 0.999772849
p_ni: 0.000227111
p_wrong: 3.9e-8
Score: 0.933
Data Source: BioPlex,STRINGDB
CTDSP1
Tbio
Family: Enzyme
Novelty: 0.0231786
p_int: 0.999740521
p_ni: 0.00023558
p_wrong: 0.000023899
Score: 0.812
Data Source: BioPlex,STRINGDB
NLN
Tbio
Family: Enzyme
Novelty: 0.01217367
p_int: 0.973146809
p_ni: 0.026853139
p_wrong: 5.3e-8
Score: 0.282
Data Source: BioPlex,STRINGDB
IDE
Tchem
Family: Enzyme
Novelty: 0.00207793
p_int: 0.893052127
p_ni: 0.106947873
Score: 0.287
Data Source: BioPlex,STRINGDB
MAG
Tchem
Novelty: 0.00085621
Score: 0.944
Data Source: STRINGDB
PLP1
Tbio
Novelty: 0.00129083
Score: 0.915
Data Source: STRINGDB
MOG
Tbio
Novelty: 0.00048664
Score: 0.907
Data Source: STRINGDB
MOK
Tbio
Family: Kinase
Novelty: 0.0116106
Score: 0.901
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.848
Data Source: STRINGDB
GFAP
Tbio
Novelty: 0.00020932
Score: 0.844
Data Source: STRINGDB
Publication Statistics
PubMed Score  6364.87

PubMed score by year
PubTator Score  4452.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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