Tbio MBP Myelin basic protein

Protein Summary

Description

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02686
• A4FU54
• A6NI84
• A8MY86
• A8MYL4
• B3KY66
• B7ZKS2
• B7ZKS4
• Q15337
• Q15338
• Q15339
• Q15340
• Q59GX3
• Q65ZS4
• Q6AI64
• Q6FH37
• Q6FI04
• Q6PK23
• MBP

Gene Name

• MBP

Ensembl ID

• ENST00000355994
• ENSP00000348273
• ENSG00000197971
• ENST00000359645
• ENSP00000352667
• ENST00000382582
• ENSP00000372025
• ENST00000397860
• ENSP00000380958
• ENST00000397863
• ENSP00000380961
• ENST00000397865
• ENSP00000380963
• ENST00000397866
• ENSP00000380964
• ENST00000580402
• ENSP00000462223

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phosphatase	1
transcription factor perturbation	0.99
hub protein	0.97
PubMedID	0.97
disease perturbation	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6734.67   (req: < 5)

Gene RIFs: 80   (req: <= 3)

Antibodies: 1187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6734.67   (req: >= 5)

Gene RIFs: 80   (req: > 3)

Antibodies: 1187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0