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Tbio
MBP
Myelin basic protein

Protein Summary
Description
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355994
  • ENSP00000348273
  • ENSG00000197971
  • ENST00000359645
  • ENSP00000352667
  • ENST00000382582
  • ENSP00000372025
  • ENST00000397860
  • ENSP00000380958
  • ENST00000397863
  • ENSP00000380961
  • ENST00000397865
  • ENSP00000380963
  • ENST00000397866
  • ENSP00000380964
  • ENST00000580402
  • ENSP00000462223
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phosphatase
1
transcription factor perturbation
0.99
hub protein
0.97
PubMedID
0.97
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6734.67   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 1187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6734.67   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 1187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0