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Tbio
FGG
Fibrinogen gamma chain

Protein Classes
Protein Summary
Description
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycop ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
biological term
0.9
PubMedID
0.79
gene perturbation
0.77
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.31   (req: < 5)
Gene RIFs: 153   (req: <= 3)
Antibodies: 584   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.31   (req: >= 5)
Gene RIFs: 153   (req: > 3)
Antibodies: 584   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
3
2
1
1.2
97.5
fibrinogen measurement
2
3
3
96.3
prothrombin time measurement
1
1
1
62.3
glycine measurement
1
1
1
50
partial thromboplastin time
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
venous thromboembolism
1
1.2
97.5
fibrinogen measurement
3
96.3
prothrombin time measurement
1
62.3
glycine measurement
1
50
partial thromboplastin time
1
7.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibrinogen gamma chain
VGNC:601
461560
Macaque
fibrinogen gamma chain
698363
Mouse
MGI:95526
99571
Rat
RGD:2613
24367
Dog
fibrinogen gamma chain
VGNC:54208
475474
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibrinogen gamma chain
Macaque
fibrinogen gamma chain
Mouse
Rat
Dog
fibrinogen gamma chain
Protein Structure (45 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02679-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 45
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (96)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Extracellular matrix organization
Gene Ontology Terms (46)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (329)
1 – 10 of 329
HIST1H2BJ
Tbio
Novelty: 0.14308844
p_int: 0.999997063
p_ni: 0.000002937
Score: 0.188
Data Source: BioPlex,STRINGDB
DDX1
Tbio
Family: Enzyme
Novelty: 0.01691884
p_int: 0.999986839
p_ni: 0.000013161
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999953911
p_ni: 0.000046089
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.999718125
p_ni: 0.000251362
p_wrong: 0.000030514
Data Source: BioPlex
ASCC1
Tbio
Novelty: 0.1280098
p_int: 0.999498504
p_ni: 0.000477644
p_wrong: 0.000023852
Score: 0.204
Data Source: BioPlex,STRINGDB
RING1
Tbio
Family: Enzyme
Novelty: 0.00729948
p_int: 0.999228455
p_ni: 0.00076754
p_wrong: 0.000004005
Score: 0.167
Data Source: BioPlex,STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
p_int: 0.999225077
p_ni: 0.000587732
p_wrong: 0.000187191
Score: 0.269
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999086365
p_ni: 0.000912159
p_wrong: 0.000001475
Data Source: BioPlex
SLC6A1
Tclin
Family: Transporter
Novelty: 0.00165116
p_int: 0.999019956
p_ni: 0.000979881
p_wrong: 1.63e-7
Data Source: BioPlex
CA8
Tbio
Family: Enzyme
Novelty: 0.0041859
p_int: 0.989646903
p_ni: 0.01034297
p_wrong: 0.000010127
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  237.31

PubMed score by year
PubTator Score  164.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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