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Tbio
FGB
Fibrinogen beta chain

Protein Classes
Protein Summary
Description
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. The protein encoded by this gene is the beta component of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302068
  • ENSP00000306099
  • ENSG00000171564

Symbol
  • HEL-S-78p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.97
cell type or tissue
0.76
protein domain
0.73
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.34   (req: < 5)
Gene RIFs: 186   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.34   (req: >= 5)
Gene RIFs: 186   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
3
4
3
12.9
96.9
low density lipoprotein cholesterol measurement
1
1
1
95.5
total cholesterol measurement
1
1
1
78.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
3
12.9
96.9
low density lipoprotein cholesterol measurement
1
95.5
total cholesterol measurement
1
78.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibrinogen beta chain
VGNC:606
461558
Macaque
fibrinogen beta chain
698487
Mouse
MGI:99501
110135
Rat
RGD:2604
24366
Dog
fibrinogen beta chain
VGNC:54207
475472
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibrinogen beta chain
Macaque
fibrinogen beta chain
Mouse
Rat
Dog
fibrinogen beta chain
Protein Structure (34 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02675-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 34
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (68)
Common Pathway of Fibrin Clot Formation (R-HSA-140875)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Common Pathway of Fibrin Clot Formation
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Extracellular matrix organization
Protein-Protein Interactions (325)
1 – 10 of 325
HIST1H2BJ
Tbio
Novelty: 0.14308844
p_int: 0.999998979
p_ni: 0.000001021
Data Source: BioPlex
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999996292
p_ni: 0.000003707
p_wrong: 1e-9
Data Source: BioPlex
DDX1
Tbio
Family: Enzyme
Novelty: 0.01691884
p_int: 0.999993491
p_ni: 0.000006505
p_wrong: 4e-9
Data Source: BioPlex
SBDS
Tbio
Novelty: 0.00818779
p_int: 0.99999258
p_ni: 0.000007416
p_wrong: 4e-9
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.999970544
p_ni: 0.000029456
Data Source: BioPlex
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999794936
p_ni: 0.000205061
p_wrong: 3e-9
Data Source: BioPlex
SPR
Tchem
Family: Enzyme
Novelty: 0.02144934
p_int: 0.999789107
p_ni: 0.000210891
p_wrong: 2e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
SLC6A1
Tclin
Family: Transporter
Novelty: 0.00165116
p_int: 0.999654382
p_ni: 0.00034561
p_wrong: 8e-9
Data Source: BioPlex
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
p_int: 0.999647588
p_ni: 0.000352412
Score: 0.302
Data Source: BioPlex,STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
p_int: 0.999415969
p_ni: 0.0000038
p_wrong: 0.00058023
Score: 0.2
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  215.34

PubMed score by year
PubTator Score  16491.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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