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Tbio
FGA
Fibrinogen alpha chain

Protein Summary
Description
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways. This gene encodes the alpha subunit of th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302053
  • ENSP00000306361
  • ENSG00000171560
  • ENST00000403106
  • ENSP00000385981

Symbol
  • Fib2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
gene perturbation
0.91
protein domain
0.85
disease
0.73
co-expressed gene
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 941.76   (req: < 5)
Gene RIFs: 182   (req: <= 3)
Antibodies: 954   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 941.76   (req: >= 5)
Gene RIFs: 182   (req: > 3)
Antibodies: 954   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (361)
HIST1H2BJ
Tbio
Novelty:  0.14308844
p_int:  0.999999306
p_ni:  6.41e-7
p_wrong:  5.3e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
DDX1
Tchem
Family:  Enzyme
Novelty:  0.01691884
p_int:  0.999993911
p_ni:  0.000006089
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.999905604
p_ni:  0.000094393
p_wrong:  3e-9
Data Source:  BioPlex
RING1
Tbio
Family:  Enzyme
Novelty:  0.00729948
p_int:  0.99960761
p_ni:  0.00039239
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999604273
p_ni:  0.000394459
p_wrong:  0.000001268
Data Source:  BioPlex
MAPK6
Tbio
Family:  Kinase
Novelty:  0.01012514
p_int:  0.999557232
p_ni:  0.000373848
p_wrong:  0.000068921
Score:  0.165
Data Source:  BioPlex,STRINGDB
SLC6A1
Tclin
Family:  Transporter
Novelty:  0.00165116
p_int:  0.999335305
p_ni:  0.00066299
p_wrong:  0.000001705
Data Source:  BioPlex
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
p_int:  0.998967723
p_ni:  0.001007897
p_wrong:  0.00002438
Score:  0.314
Data Source:  BioPlex,STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.999
Data Source:  Reactome,STRINGDB
FGG
Tbio
Novelty:  0.00404457
Score:  0.999
Data Source:  Reactome,STRINGDB
Pathways (59)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Common Pathway of Fibrin Clot Formation
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Common Pathway of Fibrin Clot Formation
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
8
14
14
12.9
99.8
7
5
2
1.2
98.2
low density lipoprotein cholesterol measurement
3
3
3
89.2
prothrombin time measurement
1
1
1
72.9
total cholesterol measurement
3
2
3
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
14
12.9
99.8
2
1.2
98.2
low density lipoprotein cholesterol measurement
3
89.2
prothrombin time measurement
1
72.9
total cholesterol measurement
3
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibrinogen alpha chain
VGNC:599
461559
Macaque
fibrinogen alpha chain
698244
Mouse
MGI:1316726
14161
Rat
RGD:2603
361969
Dog
fibrinogen alpha chain
VGNC:54205
475473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibrinogen alpha chain
Macaque
fibrinogen alpha chain
Mouse
Rat
Dog
fibrinogen alpha chain
Publication Statistics
PubMed Score 941.76
PubMed score by year
PubTator Score 491.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title