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Tbio
APOA2
Apolipoprotein A-II

Protein Summary
Description
May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367990
  • ENSP00000356969
  • ENSG00000158874

Symbol
  • apoAII
  • Apo-AII
  • ApoA-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.99
disease perturbation
0.87
biological term
0.72
disease
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 766.01   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 476   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 766.01   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 476   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (266)
ELMOD2
Tbio
Novelty:  0.10976209
p_int:  0.999963932
p_ni:  0.000035759
p_wrong:  3.08e-7
Data Source:  BioPlex
GNPAT
Tchem
Family:  Enzyme
Novelty:  0.01255689
p_int:  0.999793257
p_ni:  0.000206734
p_wrong:  1e-8
Data Source:  BioPlex
TMEM39A
Tbio
Novelty:  0.11657639
p_int:  0.999549268
p_ni:  0.000450381
p_wrong:  3.51e-7
Data Source:  BioPlex
GDE1
Tbio
Family:  Enzyme
Novelty:  0.05854843
p_int:  0.999043348
p_ni:  0.000873598
p_wrong:  0.000083054
Data Source:  BioPlex
TMEM131L
Tbio
Novelty:  0.60395527
p_int:  0.998414627
p_ni:  0.001585373
Data Source:  BioPlex
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.997695714
p_ni:  0.002296888
p_wrong:  0.000007398
Data Source:  BioPlex
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.996555591
p_ni:  0.003444409
Data Source:  BioPlex
EMC8
Tdark
Novelty:  0.2452967
p_int:  0.994293388
p_ni:  0.005706612
Data Source:  BioPlex
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.989297307
p_ni:  0.010702693
Score:  0.786
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.97977133
p_ni:  0.020228663
p_wrong:  7e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Chylomicron assembly (R-HSA-8963888)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chylomicron assembly
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Chylomicron assembly
Chylomicron remodeling
G alpha (i) signalling events
GPCR downstream signalling
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
5
5
94.7
serum non-albumin protein measurement
1
4
4
93.7
mean platelet volume
3
2
4
93
blood metabolite measurement
2
2
2
83
4
2
0
1.1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
94.7
serum non-albumin protein measurement
4
93.7
mean platelet volume
4
93
blood metabolite measurement
2
83
0
1.1
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A2
VGNC:8240
449498
Macaque
apolipoprotein A2
719946
Mouse
MGI:88050
11807
Rat
RGD:2131
25649
Dog
apolipoprotein A2
VGNC:37992
478982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein A2
Macaque
apolipoprotein A2
Mouse
Rat
Dog
apolipoprotein A2
Publication Statistics
PubMed Score 766.01
PubMed score by year
PubTator Score 788.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title