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Tbio
APOE
Apolipoprotein E

Protein Summary
Description
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:6860692, PubMed:1911868, PubMed:14754908). APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance (PubMed:6860692, PubMed:2762297, PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:14754908, PubMed:23620513). Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma (PubMed:6860692, PubMed:2762297, PubMed:9395455). As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL) (PubMed:6860692, PubMed:1911868). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252486
  • ENSP00000252486
  • ENSG00000130203

Symbol
  • AD2
  • LPG
  • APO-E
  • ApoE4
  • LDLCQ5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
1
molecular function
1
chemical
0.95
disease
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21858.14   (req: < 5)
Gene RIFs: 2432   (req: <= 3)
Antibodies: 1289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21858.14   (req: >= 5)
Gene RIFs: 2432   (req: > 3)
Antibodies: 1289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 131
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (74)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
6
3
3.1
99.9
low density lipoprotein cholesterol measurement
13
4
20
12
99.8
longevity
5
3
1
1.6
99.5
C-reactive protein measurement
5
2
6
99.3
high density lipoprotein cholesterol measurement
9
3
14
12
99.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3.1
99.9
low density lipoprotein cholesterol measurement
20
12
99.8
longevity
1
1.6
99.5
C-reactive protein measurement
6
99.3
high density lipoprotein cholesterol measurement
14
12
99.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein E
449586
Macaque
apolipoprotein E
714623
Mouse
MGI:88057
11816
Rat
RGD:2138
25728
Dog
apolipoprotein E
VGNC:38002
476438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apolipoprotein E
Macaque
apolipoprotein E
Mouse
Rat
Dog
apolipoprotein E
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02649-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Chylomicron assembly
Reactome
Chylomicron clearance
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Chylomicron assembly
Chylomicron clearance
Chylomicron remodeling
G alpha (i) signalling events
Gene Ontology Terms (158)
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (482)
1 – 10 of 482
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.999998892
p_ni: 0.000001108
Data Source: BioPlex
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.999998035
p_ni: 0.000001965
Data Source: BioPlex
MMRN1
Tbio
Novelty: 0.03378128
p_int: 0.999960004
p_ni: 0.000039913
p_wrong: 8.2e-8
Score: 0.2
Data Source: BioPlex,STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
p_int: 0.999949506
p_ni: 0.000050386
p_wrong: 1.08e-7
Score: 0.694
Data Source: BioPlex,STRINGDB
MMP3
Tchem
Novelty: 0.00041675
p_int: 0.999922274
p_ni: 0.000077208
p_wrong: 5.18e-7
Score: 0.821
Data Source: BioPlex,STRINGDB
C16orf92
Tdark
Novelty: 3.33740474
p_int: 0.999920991
p_ni: 0.000079008
p_wrong: 1e-9
Data Source: BioPlex
C9
Tbio
Novelty: 0.00749298
p_int: 0.999854944
p_ni: 0.000144993
p_wrong: 6.3e-8
Score: 0.401
Data Source: BioPlex,STRINGDB
APOC2
Tbio
Novelty: 0.0015496
p_int: 0.999179357
p_ni: 0.000811847
p_wrong: 0.000008796
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
VDAC3
Tbio
Novelty: 0.0095068
p_int: 0.999125127
p_ni: 0.000874846
p_wrong: 2.7e-8
Score: 0.225
Data Source: BioPlex,STRINGDB
MMP10
Tchem
Novelty: 0.00112113
p_int: 0.997865595
p_ni: 0.002132562
p_wrong: 0.000001842
Score: 0.694
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21858.14

PubMed score by year
PubTator Score  11855.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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