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Tbio
APOE
Apolipoprotein E

Protein Summary
Description
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:6860692, PubMed:1911868, PubMed:14754908). APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance (PubMed:6860692, PubMed:2762297, PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:14754908, PubMed:23620513). Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma (PubMed:6860692, PubMed:2762297, PubMed:9395455). As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL) (PubMed:6860692, PubMed:1911868). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252486
  • ENSP00000252486
  • ENSG00000130203

Symbol
  • AD2
  • LPG
  • APO-E
  • ApoE4
  • LDLCQ5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
1
molecular function
1
chemical
0.95
disease
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21858.14   (req: < 5)
Gene RIFs: 2432   (req: <= 3)
Antibodies: 1289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21858.14   (req: >= 5)
Gene RIFs: 2432   (req: > 3)
Antibodies: 1289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 131
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (74)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
6
3
3.1
99.9
low density lipoprotein cholesterol measurement
13
4
20
12
99.8
longevity
5
3
1
1.6
99.5
C-reactive protein measurement
5
2
6
99.3
high density lipoprotein cholesterol measurement
9
3
14
12
99.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3.1
99.9
low density lipoprotein cholesterol measurement
20
12
99.8
longevity
1
1.6
99.5
C-reactive protein measurement
6
99.3
high density lipoprotein cholesterol measurement
14
12
99.2
Protein Data Bank (17)
1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Chylomicron assembly
Reactome
Chylomicron clearance
Reactome
Chylomicron remodeling
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Chylomicron assembly
Chylomicron clearance
Chylomicron remodeling
G alpha (i) signalling events
Gene Ontology Terms (158)
Items per page:
10
1 – 10 of 19
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (482)
1 – 10 of 482
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.999998892
p_ni: 0.000001108
Data Source: BioPlex
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.999998035
p_ni: 0.000001965
Data Source: BioPlex
MMRN1
Tbio
Novelty: 0.03378128
p_int: 0.999960004
p_ni: 0.000039913
p_wrong: 8.2e-8
Score: 0.2
Data Source: BioPlex,STRINGDB
VDAC1
Tbio
Novelty: 0.0011441
p_int: 0.999949506
p_ni: 0.000050386
p_wrong: 1.08e-7
Score: 0.694
Data Source: BioPlex,STRINGDB
MMP3
Tchem
Novelty: 0.00041675
p_int: 0.999922274
p_ni: 0.000077208
p_wrong: 5.18e-7
Score: 0.821
Data Source: BioPlex,STRINGDB
C16orf92
Tdark
Novelty: 3.33740474
p_int: 0.999920991
p_ni: 0.000079008
p_wrong: 1e-9
Data Source: BioPlex
C9
Tbio
Novelty: 0.00749298
p_int: 0.999854944
p_ni: 0.000144993
p_wrong: 6.3e-8
Score: 0.401
Data Source: BioPlex,STRINGDB
APOC2
Tbio
Novelty: 0.0015496
p_int: 0.999179357
p_ni: 0.000811847
p_wrong: 0.000008796
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
VDAC3
Tbio
Novelty: 0.0095068
p_int: 0.999125127
p_ni: 0.000874846
p_wrong: 2.7e-8
Score: 0.225
Data Source: BioPlex,STRINGDB
MMP10
Tchem
Novelty: 0.00112113
p_int: 0.997865595
p_ni: 0.002132562
p_wrong: 0.000001842
Score: 0.694
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  21858.14

PubMed score by year
PubTator Score  11855.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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