Protein Summary
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids (PubMed:6860692, PubMed:1911868, PubMed:14754908). APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance (PubMed:6860692, PubMed:2762297, PubMed:1911868, PubMed:1917954, PubMed:9395455, PubMed:14754908, PubMed:23620513). Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma (PubMed:6860692, PubMed:2762297, PubMed:9395455). As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL) (PubMed:6860692, PubMed:1911868). It also binds a wide range of cellular receptors including the LDL receptor/LDLR, the LDL r ...more
- ENST00000252486
- ENSP00000252486
- ENSG00000130203
- AD2
- LPG
- APO-E
- ApoE4
- LDLCQ5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
metabolite | 1 | ||
molecular function | 1 | ||
chemical | 0.95 | ||
disease | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22340.54 (req: < 5)
Gene RIFs: 2432 (req: <= 3)
Antibodies: 1289 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22340.54 (req: >= 5)
Gene RIFs: 2432 (req: > 3)
Antibodies: 1289 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 131
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (482)
MMRN1
Novelty: 0.03378128
p_int: 0.999960004
p_ni: 0.000039913
p_wrong: 8.2e-8
Score: 0.2
Data Source: BioPlex,STRINGDB
VDAC1
Novelty: 0.0011441
p_int: 0.999949506
p_ni: 0.000050386
p_wrong: 1.08e-7
Score: 0.694
Data Source: BioPlex,STRINGDB
MMP3
Novelty: 0.00041675
p_int: 0.999922274
p_ni: 0.000077208
p_wrong: 5.18e-7
Score: 0.821
Data Source: BioPlex,STRINGDB
C16orf92
Novelty: 3.33740474
p_int: 0.999920991
p_ni: 0.000079008
p_wrong: 1e-9
Data Source: BioPlex
C9
Novelty: 0.00749298
p_int: 0.999854944
p_ni: 0.000144993
p_wrong: 6.3e-8
Score: 0.401
Data Source: BioPlex,STRINGDB
APOC2
Novelty: 0.0015496
p_int: 0.999179357
p_ni: 0.000811847
p_wrong: 0.000008796
Score: 0.993
Data Source: BioPlex,Reactome,STRINGDB
VDAC3
Novelty: 0.0095068
p_int: 0.999125127
p_ni: 0.000874846
p_wrong: 2.7e-8
Score: 0.225
Data Source: BioPlex,STRINGDB
MMP10
Novelty: 0.00112113
p_int: 0.997865595
p_ni: 0.002132562
p_wrong: 0.000001842
Score: 0.694
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (42)
Reactome (32)
KEGG (2)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Chylomicron assembly | ||||
Reactome | Chylomicron clearance | ||||
Reactome | Chylomicron remodeling | ||||
Reactome | G alpha (i) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Chylomicron assembly | ||||
Chylomicron clearance | ||||
Chylomicron remodeling | ||||
G alpha (i) signalling events | ||||
Viral Interactions (0)
Gene Ontology Terms (158)
Functions (19)
Components (27)
Processes (112)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (119)
Items per page:
1 – 5 of 119
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 35 | 75 | 113 | 8 | 100 | ||||
apolipoprotein B measurement | 2 | 63 | 64 | 100 | |||||
total cholesterol measurement | 21 | 62 | 91 | 6.8 | 100 | ||||
C-reactive protein measurement | 14 | 58 | 74 | 21.8 | 100 | ||||
27 | 63 | 2 | 2.7 | 99.9 | |||||
Items per page:
1 – 5 of 119
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 113 | 8 | 100 | ||||
apolipoprotein B measurement | 64 | 100 | |||||
total cholesterol measurement | 91 | 6.8 | 100 | ||||
C-reactive protein measurement | 74 | 21.8 | 100 | ||||
2 | 2.7 | 99.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | apolipoprotein E | 449586 | ||||||
Macaque | apolipoprotein E | 714623 | ||||||
Mouse | MGI:88057 | 11816 | ||||||
Rat | RGD:2138 | 25728 | ||||||
Dog | apolipoprotein E | VGNC:38002 | 476438 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | apolipoprotein E | |||||
Macaque | apolipoprotein E | |||||
Mouse | ||||||
Rat | ||||||
Dog | apolipoprotein E | |||||
Publication Statistics
PubMed Score 22340.54
PubMed score by year
PubTator Score 11855.59
PubTator score by year
Related Publications
Text Mined References (4208)
GeneRif Annotations (2432)
Items per page:
0 of 0
PMID | Year | Title |
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