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Tbio
TNNC2
Troponin C, skeletal muscle

Protein Summary
Description
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372555
  • ENSP00000361636
  • ENSG00000101470
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.63
disease perturbation
0.49
tissue sample
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (159)
1 – 10 of 159
MAML1
Tbio
Novelty: 0.0200407
p_int: 0.999999995
p_ni: 5e-9
Data Source: BioPlex
NRIP1
Tbio
Novelty: 0.00621822
p_int: 0.999999949
p_ni: 2.9e-8
p_wrong: 2.3e-8
Data Source: BioPlex
ZNF74
Tbio
Family: TF
Novelty: 0.14162077
p_int: 0.999999826
p_ni: 1.68e-7
p_wrong: 6e-9
Data Source: BioPlex
CLSPN
Tbio
Novelty: 0.01724032
p_int: 0.99999828
p_ni: 0.000001716
p_wrong: 5e-9
Data Source: BioPlex
SEPHS2
Tdark
Family: Enzyme
Novelty: 0.0323148
p_int: 0.999994691
p_ni: 0.000005305
p_wrong: 3e-9
Data Source: BioPlex
ITPRID2
Tbio
Novelty: 0.06728433
p_int: 0.999983686
p_ni: 0.000016314
Data Source: BioPlex
CHAMP1
Tbio
Novelty: 0.15765766
p_int: 0.99997882
p_ni: 0.000021171
p_wrong: 9e-9
Data Source: BioPlex
POGZ
Tbio
Novelty: 0.0652799
p_int: 0.99997817
p_ni: 0.00002183
Data Source: BioPlex
PML
Tbio
Novelty: 0.0021939
p_int: 0.999894145
p_ni: 0.000105855
Data Source: BioPlex
ZBTB21
Tbio
Family: TF
Novelty: 0.32967033
p_int: 0.999883056
p_ni: 0.000116944
Data Source: BioPlex
Publication Statistics
PubMed Score  6.87

PubMed score by year
PubTator Score  6.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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