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Tbio
LMNA
Prelamin-A/C

Protein Summary
Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). Prelamin-A/C can accelerate smoot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347559
  • ENSP00000292304
  • ENSG00000160789
  • ENST00000368299
  • ENSP00000357282
  • ENST00000368300
  • ENSP00000357283
  • ENST00000368301
  • ENSP00000357284
  • ENST00000448611
  • ENSP00000395597
  • ENST00000473598
  • ENSP00000421821

Symbol
  • LMN1
  • FPL
  • IDC
  • LFP
  • CDDC
  • EMD2
  • FPLD
  • HGPS
  • LDP1
  • LMN1
  • LMNC
  • MADA
  • PRO1
  • CDCD1
  • CMD1A
  • FPLD2
  • LMNL1
  • CMT2B1
  • LGMD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
ligand (protein) perturbation
1
transcription factor perturbation
1
biological process
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2740.51   (req: < 5)
Gene RIFs: 618   (req: <= 3)
Antibodies: 1465   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2740.51   (req: >= 5)
Gene RIFs: 618   (req: > 3)
Antibodies: 1465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0