Protein Summary
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). Prelamin-A/C can accelerate smoot ...more
- ENST00000347559
- ENSP00000292304
- ENSG00000160789
- ENST00000368299
- ENSP00000357282
- ENST00000368300
- ENSP00000357283
- ENST00000368301
- ENSP00000357284
- ENST00000448611
- ENSP00000395597
- ENST00000473598
- ENSP00000421821
- LMN1
- FPL
- IDC
- LFP
- CDDC
- EMD2
- FPLD
- HGPS
- LDP1
- LMN1
- LMNC
- MADA
- PRO1
- CDCD1
- CMD1A
- FPLD2
- LMNL1
- CMT2B1
- LGMD1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
ligand (protein) perturbation | 1 | ||
transcription factor perturbation | 1 | ||
biological process | 0.97 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1958.88 (req: < 5)
Gene RIFs: 495 (req: <= 3)
Antibodies: 1465 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1958.88 (req: >= 5)
Gene RIFs: 495 (req: > 3)
Antibodies: 1465 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (46)
Reactome (28)
KEGG (4)
PathwayCommons (2)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 28
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Breakdown of the nuclear lamina | ||||
Reactome | Cell Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Breakdown of the nuclear lamina | ||||
Cell Cycle | ||||
Gene Ontology Terms (34)
Functions (2)
Components (10)
Processes (22)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Protein-Protein Interactions (316)
1 – 10 of 316
FGFR1OP2
Novelty: 0.10754753
p_int: 0.97285252
p_ni: 0.027147481
Data Source: BioPlex
SYCE1
Novelty: 0.07934297
p_int: 0.967521733
p_ni: 0.032478267
Data Source: BioPlex
KPNA6
Novelty: 0.09903142
p_int: 0.848269915
p_ni: 0.151730085
Score: 0.421
Data Source: BioPlex,STRINGDB
SUN2
Novelty: 0.01877097
p_int: 0.75000428
p_ni: 0.24999572
Score: 0.972
Data Source: BioPlex,STRINGDB
CDC5L
Family: TF
Novelty: 0.00617757
Score: 0.98
Data Source: STRINGDB
CASP6
Family: Enzyme
Novelty: 0.00311641
Score: 0.97
Data Source: Reactome,STRINGDB
MAPK3
Family: Kinase
Novelty: 0.0001911
Score: 0.964
Data Source: STRINGDB
MAPK1
Family: Kinase
Novelty: 0.00046573
Score: 0.961
Data Source: STRINGDB
LMNB2
Novelty: 0.00228563
Score: 0.957
Data Source: STRINGDB
EMD
Novelty: 0.00152727
Score: 0.952
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 1958.88
PubMed score by year
PubTator Score 1568.26
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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