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Tbio
LMNA
Prelamin-A/C

Protein Summary
Description
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). Prelamin-A/C can accelerate smoot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347559
  • ENSP00000292304
  • ENSG00000160789
  • ENST00000368299
  • ENSP00000357282
  • ENST00000368300
  • ENSP00000357283
  • ENST00000368301
  • ENSP00000357284
  • ENST00000448611
  • ENSP00000395597
  • ENST00000473598
  • ENSP00000421821

Symbol
  • LMN1
  • FPL
  • IDC
  • LFP
  • CDDC
  • EMD2
  • FPLD
  • HGPS
  • LDP1
  • LMN1
  • LMNC
  • MADA
  • PRO1
  • CDCD1
  • CMD1A
  • FPLD2
  • LMNL1
  • CMT2B1
  • LGMD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
ligand (protein) perturbation
1
transcription factor perturbation
1
biological process
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1958.88   (req: < 5)
View Publications
Gene RIFs: 495   (req: <= 3)
View Gene RIFs
Antibodies: 1465   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1958.88   (req: >= 5)
Gene RIFs: 495   (req: > 3)
Antibodies: 1465   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (46)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
177 targets
R-HSA-109581
Reactome
Apoptotic cleavage of cellular proteins
38 targets
R-HSA-111465
Reactome
Apoptotic execution phase
52 targets
R-HSA-75153
Reactome
Breakdown of the nuclear lamina
3 targets
R-HSA-352238
Reactome
Cell Cycle
597 targets
R-HSA-1640170
Name
Explore in Pharos
Explore in Source
Apoptosis
177 targets
R-HSA-109581
Apoptotic cleavage of cellular proteins
38 targets
R-HSA-111465
Apoptotic execution phase
52 targets
R-HSA-75153
Breakdown of the nuclear lamina
3 targets
R-HSA-352238
Cell Cycle
597 targets
R-HSA-1640170
Gene Ontology Terms (34)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
structural molecule activity
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (316)
1 – 10 of 316
FGFR1OP2
Tbio
Novelty: 0.10754753
p_int: 0.97285252
p_ni: 0.027147481
Data Source: BioPlex
SYCE1
Tbio
Novelty: 0.07934297
p_int: 0.967521733
p_ni: 0.032478267
Data Source: BioPlex
KPNA6
Tbio
Novelty: 0.09903142
p_int: 0.848269915
p_ni: 0.151730085
Score: 0.421
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01877097
p_int: 0.75000428
p_ni: 0.24999572
Score: 0.972
Data Source: BioPlex,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00617757
Score: 0.98
Data Source: STRINGDB
CASP6
Tchem
Family: Enzyme
Novelty: 0.00311641
Score: 0.97
Data Source: Reactome,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.0001911
Score: 0.964
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00046573
Score: 0.961
Data Source: STRINGDB
LMNB2
Tbio
Novelty: 0.00228563
Score: 0.957
Data Source: STRINGDB
EMD
Tbio
Novelty: 0.00152727
Score: 0.952
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1958.88

PubMed score by year
PubTator Score  1568.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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