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Tbio
KRT6A
Keratin, type II cytoskeletal 6A

Protein Summary
Description
Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330722
  • ENSP00000369317
  • ENSG00000205420

Symbol
  • K6A
  • KRT6D
  • K6A
  • K6C
  • K6D
  • PC3
  • CK6A
  • CK6C
  • CK6D
  • CK-6C
  • CK-6E
  • KRT6C
  • KRT6D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
gene perturbation
0.74
tissue
0.64
PubMedID
0.63
cell line
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.92   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.92   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cutaneous squamous cell carcinoma
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cutaneous squamous cell carcinoma
1
4.7
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 6A
VGNC:8450
451918
Macaque
keratin, type II cytoskeletal 6C
100424162
Mouse
MGI:1100845
16687
Cow
keratin 6B
404115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 6A
Macaque
keratin, type II cytoskeletal 6C
Mouse
Cow
keratin 6B
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02538-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (80)
1 – 10 of 80
KRT6B
Tbio
Novelty: 0.00152754
Score: 0.979
Data Source: STRINGDB
KRT17
Tbio
Novelty: 0.00278761
Score: 0.974
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00503235
Score: 0.97
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.00088743
Score: 0.969
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.962
Data Source: STRINGDB
KRT6C
Tbio
Novelty: 0.11659743
Score: 0.952
Data Source: STRINGDB
KRT13
Tbio
Novelty: 0.00468754
Score: 0.947
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00351898
Score: 0.941
Data Source: STRINGDB
KRT9
Tbio
Novelty: 0.00787691
Score: 0.936
Data Source: STRINGDB
KRT18
Tbio
Novelty: 0.00069055
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.92

PubMed score by year
PubTator Score  207.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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