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Tbio
KRT14
Keratin, type I cytoskeletal 14

Protein Summary
Description
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000167586
  • ENSP00000167586
  • ENSG00000186847

Symbol
  • K14
  • NFJ
  • CK14
  • EBS3
  • EBS4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
cellular component
0.79
gene perturbation
0.76
virus perturbation
0.68
biological term
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 970.76   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 1129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 970.76   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 1129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (163)
KRT5
Tbio
Novelty:  0.00072336
Score:  0.999
Data Source:  STRINGDB
KRT3
Tbio
Novelty:  0.00489796
Score:  0.996
Data Source:  STRINGDB
KRT6B
Tbio
Novelty:  0.00152754
Score:  0.97
Data Source:  STRINGDB
KRT6A
Tbio
Novelty:  0.00789111
Score:  0.969
Data Source:  STRINGDB
KRT16
Tbio
Novelty:  0.00503235
Score:  0.967
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.963
Data Source:  STRINGDB
KRT6C
Tbio
Novelty:  0.11659743
Score:  0.956
Data Source:  STRINGDB
KRT4
Tbio
Novelty:  0.00434637
Score:  0.945
Data Source:  STRINGDB
KRT7
Tbio
Novelty:  0.00039796
Score:  0.944
Data Source:  STRINGDB
KRT8
Tbio
Novelty:  0.00093008
Score:  0.942
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (108)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 14
VGNC:9351
100610237
Mouse
MGI:96688
16664
Rat
RGD:1307463
287701
Dog
keratin 14
100685323
Cow
keratin 14
VGNC:50205
404111
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 14
Mouse
Rat
Dog
keratin 14
Cow
keratin 14
Publication Statistics
PubMed Score 970.76
PubMed score by year
PubTator Score 733.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title