Protein Summary
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perf ...more
- ENST00000227251
- ENSP00000227251
- ENSG00000109846
- ENST00000526180
- ENSP00000436051
- ENST00000527950
- ENSP00000437149
- ENST00000531198
- ENSP00000434247
- ENST00000533475
- ENSP00000433560
- ENST00000616970
- ENSP00000483554
- CRYA2
- HSPB5
- MFM2
- CRYA2
- CTPP2
- HSPB5
- CMD1II
- CTRCT16
- HEL-S-101
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.99 | ||
gene perturbation | 0.97 | ||
biological process | 0.91 | ||
PubMedID | 0.86 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 239.65 (req: < 5)
Gene RIFs: 234 (req: <= 3)
Antibodies: 1492 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 239.65 (req: >= 5)
Gene RIFs: 234 (req: > 3)
Antibodies: 1492 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 33
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (163)
NYNRIN
Novelty: 0.12231563
p_int: 0.999998978
p_ni: 0.000001022
Score: 0.273
Data Source: BioPlex,STRINGDB
PRELID1
Novelty: 0.05605197
p_int: 0.999966491
p_ni: 0.000033509
p_wrong: 1e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
CC2D1A
Novelty: 0.01970021
p_int: 0.999870657
p_ni: 0.000121434
p_wrong: 0.000007909
Score: 0.205
Data Source: BioPlex,STRINGDB
CCDC85B
Novelty: 0.02034018
p_int: 0.999184863
p_ni: 0.000807786
p_wrong: 0.000007351
Data Source: BioPlex
RBM24
Novelty: 0.04562076
p_int: 0.99785669
p_ni: 0.00214331
Score: 0.169
Data Source: BioPlex,STRINGDB
PI4KA
Family: Kinase
Novelty: 0.01701469
p_int: 0.997186168
p_ni: 0.002813832
Data Source: BioPlex
CDC23
Novelty: 0.0168525
p_int: 0.993867343
p_ni: 0.005677867
p_wrong: 0.00045479
Data Source: BioPlex
HNRNPUL2
Novelty: 0.2133502
p_int: 0.98964146
p_ni: 0.01035854
Score: 0.223
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (4)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | HSF1-dependent transactivation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
HSF1-dependent transactivation | ||||
Viral Interactions (0)
Gene Ontology Terms (52)
Functions (8)
Components (19)
Processes (25)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
waist circumference | 1 | 2 | 2 | 64.2 | |||||
waist-hip ratio | 1 | 2 | 2 | 63.9 | |||||
BMI-adjusted waist-hip ratio | 1 | 2 | 2 | 61.8 | |||||
smoking status measurement | 1 | 1 | 1 | 56.4 | |||||
mean platelet volume | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
waist circumference | 2 | 64.2 | |||||
waist-hip ratio | 2 | 63.9 | |||||
BMI-adjusted waist-hip ratio | 2 | 61.8 | |||||
smoking status measurement | 1 | 56.4 | |||||
mean platelet volume | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | crystallin alpha B | VGNC:3129 | 451543 | |||||
Macaque | crystallin alpha B | 710747 | ||||||
Mouse | MGI:88516 | 12955 | ||||||
Rat | RGD:2414 | 25420 | ||||||
Dog | crystallin alpha B | VGNC:39635 | 479441 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | crystallin alpha B | |||||
Macaque | crystallin alpha B | |||||
Mouse | ||||||
Rat | ||||||
Dog | crystallin alpha B | |||||
Publication Statistics
PubMed Score 239.65
PubMed score by year
PubTator Score 143.13
PubTator score by year
Related Publications
Text Mined References (292)
GeneRif Annotations (234)
Items per page:
0 of 0
PMID | Year | Title |
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