Tchem CRYAB Alpha-crystallin B chain

Protein Summary

Description

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• P02511
• B0YIX0
• O43416
• Q9UC37
• Q9UC38
• Q9UC39
• Q9UC40
• Q9UC41

Gene Name

• CRYAB

Ensembl ID

• ENST00000227251
• ENSP00000227251
• ENSG00000109846
• ENST00000526180
• ENSP00000436051
• ENST00000527950
• ENSP00000437149
• ENST00000531198
• ENSP00000434247
• ENST00000533475
• ENSP00000433560
• ENST00000616970
• ENSP00000483554

Symbol

• CRYA2
• HSPB5
• MFM2
• CRYA2
• CTPP2
• HSPB5
• CMD1II
• CTRCT16
• HEL-S-101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
gene perturbation	0.97
biological process	0.91
PubMedID	0.86
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.18   (req: < 5)

Gene RIFs: 285   (req: <= 3)

Antibodies: 1492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.18   (req: >= 5)

Gene RIFs: 285   (req: > 3)

Antibodies: 1492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0