Tchem CRYAB Alpha-crystallin B chain

Protein Summary

Description

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• P02511
• B0YIX0
• O43416
• Q9UC37
• Q9UC38
• Q9UC39
• Q9UC40
• Q9UC41

Gene Name

• CRYAB

Ensembl ID

• ENST00000227251
• ENSP00000227251
• ENSG00000109846
• ENST00000526180
• ENSP00000436051
• ENST00000527950
• ENSP00000437149
• ENST00000531198
• ENSP00000434247
• ENST00000533475
• ENSP00000433560
• ENST00000616970
• ENSP00000483554

Symbol

• CRYA2
• HSPB5
• MFM2
• CRYA2
• CTPP2
• HSPB5
• CMD1II
• CTRCT16
• HEL-S-101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.99
gene perturbation	0.97
biological process	0.91
PubMedID	0.86
transcription factor perturbation	0.84

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.65   (req: < 5)

Gene RIFs: 234   (req: <= 3)

Antibodies: 1492   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.65   (req: >= 5)

Gene RIFs: 234   (req: > 3)

Antibodies: 1492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

25-hydroxycholesterol

CRYABTchem

EC50 : 6.5

CHEMBL4203007

CRYABTchem

EC50 : 7.24

CHEMBL4204376

CRYABTchem

EC50 : 7.75

CHEMBL4209249

CRYABTchem

EC50 : 7.58

CHEMBL4218328

CRYABTchem

EC50 : 7.19

CHEMBL4205794

CRYABTchem

EC50 : 6.97

GWAS Traits (9)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist circumference	EFO_0004342	1	2	2		64.2
waist-hip ratio	EFO_0004343	1	2	2		63.9
BMI-adjusted waist-hip ratio	EFO_0007788	1	2	2		61.8
smoking status measurement	EFO_0006527	1	1	1		56.4
mean platelet volume	EFO_0004584	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist circumference	EFO_0004342	2		64.2
waist-hip ratio	EFO_0004343	2		63.9
BMI-adjusted waist-hip ratio	EFO_0007788	2		61.8
smoking status measurement	EFO_0006527	1		56.4
mean platelet volume	EFO_0004584	1		49.5

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	crystallin alpha B	VGNC:3129	451543
Macaque	crystallin alpha B		710747
Mouse	crystallin, alpha B	MGI:88516	12955
Rat	crystallin, alpha B	RGD:2414	25420
Dog	crystallin alpha B	VGNC:39635	479441

Species	Name	OMA	EggNOG	Inparanoid
Chimp	crystallin alpha B
Macaque	crystallin alpha B
Mouse	crystallin, alpha B
Rat	crystallin, alpha B
Dog	crystallin alpha B

Protein Structure (18 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02511-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (9)

Reactome (4)

KEGG (2)

PathwayCommons (3)

Cellular response to heat stress (R-HSA-3371556)

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Find Similar Targets

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	HSF1-dependent transactivation	36 targets	R-HSA-3371571

Name	Explore in Pharos	Explore in Source
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
HSF1-dependent transactivation	36 targets	R-HSA-3371571

Gene Ontology Terms (52)

Functions (8)

Components (19)

Processes (25)

Find Similar Targets

Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
amyloid-beta binding	Inferred from Physical Interaction (IPI)	ARUK-UCL
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
protein-containing complex binding	Inferred from Physical Interaction (IPI)	ARUK-UCL
unfolded protein binding	Inferred from Physical Interaction (IPI)	UniProtKB
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
microtubule binding	Inferred from Electronic Annotation (IEA)	Ensembl
structural constituent of eye lens	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (163)

Explore Interacting Targets

1 – 10 of 163

• See Interactions on String-DB

NYNRIN

Tdark

Novelty:  0.12231563

p_int:  0.999998978

p_ni:  0.000001022

Score:  0.273

Data Source:  BioPlex,STRINGDB

PRELID1

Tbio

Novelty:  0.05605197

p_int:  0.999966491

p_ni:  0.000033509

p_wrong:  1e-9

Score:  0.205

Data Source:  BioPlex,STRINGDB

CC2D1A

Tbio

Novelty:  0.01970021

p_int:  0.999870657

p_ni:  0.000121434

p_wrong:  0.000007909

Score:  0.205

Data Source:  BioPlex,STRINGDB

GDF5

Tbio

Novelty:  0.00218118

p_int:  0.999602847

p_ni:  0.000397153

Data Source:  BioPlex

CCDC85B

Tdark

Novelty:  0.02034018

p_int:  0.999184863

p_ni:  0.000807786

p_wrong:  0.000007351

Data Source:  BioPlex

RBM24

Tbio

Novelty:  0.04562076

p_int:  0.99785669

p_ni:  0.00214331

Score:  0.169

Data Source:  BioPlex,STRINGDB

PI4KA

Tchem

Family:  Kinase

Novelty:  0.01701469

p_int:  0.997186168

p_ni:  0.002813832

Data Source:  BioPlex

CDC23

Tbio

Novelty:  0.0168525

p_int:  0.993867343

p_ni:  0.005677867

p_wrong:  0.00045479

Data Source:  BioPlex

CCDC85C

Tbio

Novelty:  0.30053883

p_int:  0.992411571

p_ni:  0.007588429

Data Source:  BioPlex

HNRNPUL2

Tbio

Novelty:  0.2133502

p_int:  0.98964146

p_ni:  0.01035854

Score:  0.223

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  239.65

PubMed score by year

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PubTator Score  143.13

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cardiomyopathy
Cataract
Chaperone
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Eye lens protein

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
mean platelet volume
red blood cell distribution width
smoking status measurement
triglyceride measurement
waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging
muscle phenotype
respiratory system phenotype
vision/eye phenotype