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Tchem
CRYAB
Alpha-crystallin B chain

Protein Summary
Description
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perf ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227251
  • ENSP00000227251
  • ENSG00000109846
  • ENST00000526180
  • ENSP00000436051
  • ENST00000527950
  • ENSP00000437149
  • ENST00000531198
  • ENSP00000434247
  • ENST00000533475
  • ENSP00000433560
  • ENST00000616970
  • ENSP00000483554

Symbol
  • CRYA2
  • HSPB5
  • MFM2
  • CRYA2
  • CTPP2
  • HSPB5
  • CMD1II
  • CTRCT16
  • HEL-S-101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
gene perturbation
0.97
biological process
0.91
PubMedID
0.86
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.65   (req: < 5)
Gene RIFs: 234   (req: <= 3)
Antibodies: 1492   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 239.65   (req: >= 5)
Gene RIFs: 234   (req: > 3)
Antibodies: 1492   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
2
2
64.2
waist-hip ratio
1
2
2
63.9
BMI-adjusted waist-hip ratio
1
2
2
61.8
smoking status measurement
1
1
1
56.4
mean platelet volume
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
2
64.2
waist-hip ratio
2
63.9
BMI-adjusted waist-hip ratio
2
61.8
smoking status measurement
1
56.4
mean platelet volume
1
49.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin alpha B
VGNC:3129
451543
Macaque
crystallin alpha B
710747
Mouse
MGI:88516
12955
Rat
RGD:2414
25420
Dog
crystallin alpha B
VGNC:39635
479441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin alpha B
Macaque
crystallin alpha B
Mouse
Rat
Dog
crystallin alpha B
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P02511-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1-dependent transactivation
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1-dependent transactivation
Gene Ontology Terms (52)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (163)
1 – 10 of 163
NYNRIN
Tdark
Novelty:  0.12231563
p_int:  0.999998978
p_ni:  0.000001022
Score:  0.273
Data Source:  BioPlex,STRINGDB
PRELID1
Tbio
Novelty:  0.05605197
p_int:  0.999966491
p_ni:  0.000033509
p_wrong:  1e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
CC2D1A
Tbio
Novelty:  0.01970021
p_int:  0.999870657
p_ni:  0.000121434
p_wrong:  0.000007909
Score:  0.205
Data Source:  BioPlex,STRINGDB
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.999602847
p_ni:  0.000397153
Data Source:  BioPlex
CCDC85B
Tdark
Novelty:  0.02034018
p_int:  0.999184863
p_ni:  0.000807786
p_wrong:  0.000007351
Data Source:  BioPlex
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.99785669
p_ni:  0.00214331
Score:  0.169
Data Source:  BioPlex,STRINGDB
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.997186168
p_ni:  0.002813832
Data Source:  BioPlex
CDC23
Tbio
Novelty:  0.0168525
p_int:  0.993867343
p_ni:  0.005677867
p_wrong:  0.00045479
Data Source:  BioPlex
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.992411571
p_ni:  0.007588429
Data Source:  BioPlex
HNRNPUL2
Tbio
Novelty:  0.2133502
p_int:  0.98964146
p_ni:  0.01035854
Score:  0.223
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  239.65

PubMed score by year
PubTator Score  143.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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