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Tbio
HBZ
Hemoglobin subunit zeta

Protein Summary
Description
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252951
  • ENSP00000252951
  • ENSG00000130656

Symbol
  • HBZ2
  • HBZ1
  • HBZ-T1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
cell type or tissue
0.8
interacting protein
0.77
protein domain
0.73
molecular function
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.45   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.45   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
BIRC5
Tchem
Novelty:  0.00332112
p_int:  0.999960695
p_ni:  0.000039305
Score:  0.164
Data Source:  BioPlex,STRINGDB
SIRT5
Tchem
Family:  Epigenetic
Novelty:  0.00225239
p_int:  0.999084113
p_ni:  0.000894879
p_wrong:  0.000021009
Score:  0.232
Data Source:  BioPlex,STRINGDB
MRPL34
Tdark
Novelty:  1.17388411
p_int:  0.938785982
p_ni:  0.061214018
Score:  0.169
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.938785982
p_ni:  0.061214018
Data Source:  BioPlex
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.870946699
p_ni:  0.129053301
Score:  0.189
Data Source:  BioPlex,STRINGDB
HBE1
Tbio
Novelty:  0.00125958
Score:  0.996
Data Source:  STRINGDB
HBB
Tbio
Novelty:  0.00049683
Score:  0.99
Data Source:  STRINGDB
HBG1
Tbio
Novelty:  0.00384136
Score:  0.965
Data Source:  STRINGDB
HBD
Tbio
Novelty:  0.00203187
Score:  0.944
Data Source:  STRINGDB
HBG2
Tbio
Novelty:  0.01145628
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
10
18
21
99.9
mean corpuscular volume
5
9
12
98.6
mean corpuscular hemoglobin
3
5
5
98.3
reticulocyte measurement
3
13
18
98.3
red blood cell distribution width
5
7
9
97.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
21
99.9
mean corpuscular volume
12
98.6
mean corpuscular hemoglobin
5
98.3
reticulocyte measurement
18
98.3
red blood cell distribution width
9
97.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit zeta
VGNC:51580
100608245
Mouse
MGI:96019
15126
Rat
RGD:1307486
287168
Dog
hemoglobin subunit zeta-like
100855600
Horse
hemoglobin subunit zeta
VGNC:52395
100065056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hemoglobin subunit zeta
Mouse
Rat
Dog
hemoglobin subunit zeta-like
Horse
hemoglobin subunit zeta
Publication Statistics
PubMed Score 346.45
PubMed score by year
PubTator Score 73.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title