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Tbio
HLA-DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
biological term
0.95
disease
0.93
phenotype
0.77
tissue sample
0.75


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1980.58   (req: < 5)
Gene RIFs: 235   (req: <= 3)
Antibodies: 638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1980.58   (req: >= 5)
Gene RIFs: 235   (req: > 3)
Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (207)
Items per page:
1 – 5 of 207
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
13
13
0
1.2
99.7
3
3
0
5.5
99.2
2
2
0
5.7
99.1
2
2
0
5.7
99.1
2
2
0
5.7
99.1
Items per page:
1 – 5 of 207
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
99.7
0
5.5
99.2
0
5.7
99.1
0
5.7
99.1
0
5.7
99.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95895
14960
Rat
RGD:1595867
309621
Horse
MHC class II DQ-alpha
100052249
Pig
MHC class II histocompatibility antigen SLA-DQA
100153387
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
MHC class II DQ-alpha
Pig
MHC class II histocompatibility antigen SLA-DQA
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (44)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (341)
1 – 10 of 341
GALT
Tbio
Family: Enzyme
Novelty: 0.0120291
p_int: 0.999652656
p_ni: 0.00018898
p_wrong: 0.000158364
Score: 0.228
Data Source: BioPlex,STRINGDB
TMEM219
Tdark
Novelty: 0.33292987
p_int: 0.996264602
p_ni: 0.003660364
p_wrong: 0.000075034
Score: 0.163
Data Source: BioPlex,STRINGDB
SLC38A9
Tbio
Family: Transporter
Novelty: 0.0879703
p_int: 0.995164633
p_ni: 0.004834689
p_wrong: 6.78e-7
Score: 0.163
Data Source: BioPlex,STRINGDB
MFSD8
Tbio
Novelty: 0.03388459
p_int: 0.994082648
p_ni: 0.005917248
p_wrong: 1.04e-7
Score: 0.158
Data Source: BioPlex,STRINGDB
EFNB1
Tbio
Novelty: 0.00523161
p_int: 0.992083573
p_ni: 0.007916426
p_wrong: 1e-9
Data Source: BioPlex
CUX1
Tbio
Novelty: 0.00415896
p_int: 0.985380763
p_ni: 0.014619235
p_wrong: 2e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
MYO19
Tbio
Novelty: 0.13070371
p_int: 0.982035001
p_ni: 0.017964999
Score: 0.188
Data Source: BioPlex,STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
p_int: 0.977883261
p_ni: 0.022116739
Score: 0.979
Data Source: BioPlex,STRINGDB
KCNJ8
Tbio
Family: IC
Novelty: 0.00369886
p_int: 0.966262023
p_ni: 0.033737975
p_wrong: 2e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
CD14
Tbio
Novelty: 0.00872424
p_int: 0.923122317
p_ni: 0.00011445
p_wrong: 0.076763233
Data Source: BioPlex
Publication Statistics
PubMed Score  1980.58

PubMed score by year
PubTator Score  900.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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