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Tbio
HLA-DQA2
HLA class II histocompatibility antigen, DQ alpha 2 chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241802
  • ENSP00000241802
  • ENSG00000206301
  • ENST00000374940
  • ENSP00000364076
  • ENSG00000237541
  • ENST00000415898
  • ENSP00000400695
  • ENSG00000231526
  • ENST00000443184
  • ENSP00000405833
  • ENSG00000257473
  • ENST00000446482
  • ENSP00000390725
  • ENSG00000225103
  • ENST00000447735
  • ENSP00000393431
  • ENSG00000223793
  • ENST00000449560
  • ENSP00000401098
  • ENSG00000233192
  • ENST00000453672
  • ENSP00000387768
  • ENSG00000231823
  • ENST00000546801
  • ENSP00000447668
  • ENST00000551533
  • ENSP00000448003

Symbol
  • HLA-DXA
  • HLA-DCA
  • HLA-DXA
  • HLADQA2
  • DC-alpha
  • DX-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.71
disease
0.69
cellular component
0.68
tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.55   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.55   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1
75.3
Oral ulcer
1
1
0
1
75.3
1
1
0
1.2
54.1
1
1
0
1.2
54.1
mosquito bite reaction itch intensity measurement
1
1
1
47.1
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1
75.3
Oral ulcer
0
1
75.3
0
1.2
54.1
0
1.2
54.1
mosquito bite reaction itch intensity measurement
1
47.1
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DQ alpha 2
471976
Opossum
H-2 class II histocompatibility antigen, A-U alpha chain-like
100026112
Zebrafish
ZDB-GENE-041124-5
368743
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DQ alpha 2
Opossum
H-2 class II histocompatibility antigen, A-U alpha chain-like
Zebrafish
Pathways (60)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Gene Ontology Terms (17)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (301)
1 – 10 of 301
HLA-DQB1
Tbio
Novelty: 0.00197952
Score: 0.989
Data Source: STRINGDB
HLA-DQB2
Tbio
Novelty: 0.07062006
Score: 0.989
Data Source: STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.984
Data Source: Reactome,STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
HLA-B
Tbio
Novelty: 0.00790207
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  254.55

PubMed score by year
PubTator Score  28.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer