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Tbio
HLA-DRA
HLA class II histocompatibility antigen, DR alpha chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383127
  • ENSP00000372608
  • ENSG00000227993
  • ENST00000383259
  • ENSP00000372746
  • ENSG00000206308
  • ENST00000395388
  • ENSP00000378786
  • ENSG00000204287
  • ENST00000411524
  • ENSP00000405295
  • ENSG00000234794
  • ENST00000414698
  • ENSP00000402951
  • ENSG00000230726
  • ENST00000416883
  • ENSP00000410443
  • ENSG00000228987
  • ENST00000442960
  • ENSP00000404533
  • ENSG00000226260

Symbol
  • HLA-DRA1
  • HLA-DRA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
virus perturbation
0.94
protein domain
0.92
phenotype
0.79
disease
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.5   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 1684   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.5   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 1684   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (105)
Items per page:
1 – 5 of 105
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
2.8
98.1
2
2
0
2.5
93.3
2
2
0
2.5
93.3
2
2
0
2.5
93.3
2
2
0
2.5
93.3
Items per page:
1 – 5 of 105
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.8
98.1
0
2.5
93.3
0
2.5
93.3
0
2.5
93.3
0
2.5
93.3
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DR alpha
462591
Rat
RGD:1593283
294269
Cow
major histocompatibility complex, class II, DR alpha
506214
Platypus
MHC class II DR alpha
100079322
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class II, DR alpha
Rat
Cow
major histocompatibility complex, class II, DR alpha
Platypus
MHC class II DR alpha
Protein Data Bank (100)
1 – 5 of 100
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (49)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Protein-Protein Interactions (423)
1 – 10 of 423
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999991565
p_ni: 0.000008428
p_wrong: 8e-9
Data Source: BioPlex
HLA-DRB5
Tbio
Novelty: 0.00291303
p_int: 0.999899141
p_ni: 0.000004526
p_wrong: 0.000096334
Score: 0.998
Data Source: BioPlex,STRINGDB
AP1G2
Tbio
Novelty: 0.17203425
p_int: 0.999625724
p_ni: 0.000374273
p_wrong: 2e-9
Data Source: BioPlex
SDR39U1
Tdark
Family: Enzyme
Novelty: 0.38626113
p_int: 0.999575412
p_ni: 0.000004245
p_wrong: 0.000420343
Data Source: BioPlex
KLK4
Tchem
Family: Enzyme
Novelty: 0.00019849
p_int: 0.999486575
p_ni: 0.000016976
p_wrong: 0.000496449
Score: 0.806
Data Source: BioPlex,STRINGDB
NXPE3
Tdark
Novelty: 1.5063521
p_int: 0.998688983
p_ni: 0.001311009
p_wrong: 8e-9
Data Source: BioPlex
HLA-DMB
Tbio
Novelty: 0.02289537
p_int: 0.998524208
p_ni: 0.001148806
p_wrong: 0.000326987
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
SLC25A42
Tbio
Family: Transporter
Novelty: 0.15737382
p_int: 0.998150434
p_ni: 0.000010192
p_wrong: 0.001839374
Data Source: BioPlex
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.998036503
p_ni: 0.001963497
Data Source: BioPlex
DSE
Tbio
Family: Enzyme
Novelty: 0.02945465
p_int: 0.99705408
p_ni: 0.002911553
p_wrong: 0.000034367
Data Source: BioPlex
Publication Statistics
PubMed Score  161.50

PubMed score by year
PubTator Score  133.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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