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Tbio
P01889
HLA class I histocompatibility antigen, B-7 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412585
  • ENSP00000399168
  • ENSG00000234745

Symbol
  • HLAB
  • AS
  • HLAB
  • B-4901
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4234.52   (req: < 5)
Gene RIFs: 821   (req: <= 3)
Antibodies: 650   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4234.52   (req: >= 5)
Gene RIFs: 821   (req: > 3)
Antibodies: 650   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (288)
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.999999626
p_ni:  3.74e-7
Score:  0.966
Data Source:  BioPlex,STRINGDB
P10321
Tbio
Novelty:  0.00698601
p_int:  0.999999446
p_ni:  5.54e-7
Score:  0.976
Data Source:  BioPlex,STRINGDB
P10314
Tbio
Novelty:  0.00270731
p_int:  0.999998547
p_ni:  0.000001453
Score:  0.986
Data Source:  BioPlex,STRINGDB
SGSM3
Tbio
Novelty:  0.00976528
p_int:  0.999621273
p_ni:  0.000378727
Score:  0.229
Data Source:  BioPlex,STRINGDB
ARFGEF2
Tbio
Novelty:  0.05568966
p_int:  0.999338144
p_ni:  0.000661856
Score:  0.192
Data Source:  BioPlex,STRINGDB
ERAP1
Tchem
Family:  Enzyme
Novelty:  0.00404539
p_int:  0.995685228
p_ni:  0.004314772
Score:  0.676
Data Source:  BioPlex,STRINGDB
WDFY3
Tbio
Novelty:  0.01670166
p_int:  0.995062969
p_ni:  0.004937031
Score:  0.722
Data Source:  BioPlex,STRINGDB
HLA-G
Tbio
Novelty:  0.0009462
p_int:  0.993953561
p_ni:  0.006046439
Score:  0.969
Data Source:  BioPlex,STRINGDB
ARFGEF1
Tbio
Novelty:  0.16148196
p_int:  0.99288031
p_ni:  0.007119689
p_wrong:  1e-9
Data Source:  BioPlex
ADAM21
Tdark
Family:  Enzyme
Novelty:  0.16068055
p_int:  0.992643808
p_ni:  0.007356192
Data Source:  BioPlex
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (42)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (942)
Items per page:
1 – 5 of 942
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
9
60
99.7
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
120
99.7
lymphocyte count
4
9
10
99.7
lymphocyte count
4
9
60
99.7
Items per page:
1 – 5 of 942
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
60
99.7
lymphocyte count
50
99.7
lymphocyte count
120
99.7
lymphocyte count
10
99.7
lymphocyte count
60
99.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 4234.52
PubMed score by year
PubTator Score 8017.41
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title