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Tbio
IGHA1
Immunoglobulin heavy constant alpha 1

Protein Summary
Description
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390547
  • ENSP00000374989
  • ENSG00000211895
  • ENST00000633714
  • ENSP00000488021
  • ENSG00000282633

Symbol
  • IgA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
tissue
0.69
disease
0.57
interacting protein
0.57
tissue sample
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999643385
p_ni:  0.000356615
Data Source:  BioPlex
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.999463197
p_ni:  0.000536803
Data Source:  BioPlex
GTF2B
Tbio
Novelty:  0.00179492
p_int:  0.99335593
p_ni:  0.006644067
p_wrong:  4e-9
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.990638173
p_ni:  0.009361827
Data Source:  BioPlex
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.989086747
p_ni:  0.010913252
p_wrong:  1e-9
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.981965288
p_ni:  0.018034451
p_wrong:  2.61e-7
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.975430158
p_ni:  0.024569842
Data Source:  BioPlex
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.967813061
p_ni:  0.032186924
p_wrong:  1.5e-8
Data Source:  BioPlex
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.964848984
p_ni:  0.035151016
Data Source:  BioPlex
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.96283208
p_ni:  0.037167915
p_wrong:  5e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Cell surface interactions at the vascular wall
Hemostasis
Scavenging of heme from plasma
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IgG index
1
1
1
81.9
IgG index
1
1
1
81.9
serum albumin measurement
1
2
2
67.6
serum albumin measurement
1
2
2
67.6
serum IgG measurement
1
1
1
65.4
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IgG index
1
81.9
IgG index
1
81.9
serum albumin measurement
2
67.6
serum albumin measurement
2
67.6
serum IgG measurement
1
65.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 951.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title