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Tclin
IGHE
Immunoglobulin heavy constant epsilon

Protein Summary
Description
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390541
  • ENSP00000374983
  • ENSG00000211891
  • ENST00000610670
  • ENSP00000481089
  • ENSG00000276192

Symbol
  • IgE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.88
cell type or tissue
0.88
biological term
0.61
chemical
0.45
pathway
0.37


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
LAT2
Tbio
Novelty:  0.01475258
Data Source:  Reactome
FCER1G
Tbio
Novelty:  0.00783146
Data Source:  Reactome
GRB2
Tchem
Novelty:  0.00091605
Data Source:  Reactome
SHC1
Tchem
Novelty:  0.00083615
Data Source:  Reactome
IGKC
Tdark
Data Source:  Reactome
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Data Source:  Reactome
FCER1A
Tbio
Novelty:  0.00362182
Data Source:  Reactome
SOS1
Tchem
Novelty:  0.00285343
Data Source:  Reactome
MS4A2
Tbio
Novelty:  0.07049421
Data Source:  Reactome
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Data Source:  Reactome
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FCERI mediated Ca+2 mobilization
Reactome
FCERI mediated MAPK activation
Reactome
FCERI mediated NF-kB activation
Reactome
Fc epsilon receptor (FCERI) signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FCERI mediated Ca+2 mobilization
FCERI mediated MAPK activation
FCERI mediated NF-kB activation
Fc epsilon receptor (FCERI) signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
35
12
43
95.4
blood protein measurement
35
12
43
95.4
serum non-albumin protein measurement
1
2
2
78.4
serum non-albumin protein measurement
1
2
2
78.4
calcium measurement
3
3
3
73.7
Items per page:
1 – 5 of 22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
43
95.4
blood protein measurement
43
95.4
serum non-albumin protein measurement
2
78.4
serum non-albumin protein measurement
2
78.4
calcium measurement
3
73.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 2954.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title