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Tbio
PIGR
Polymeric immunoglobulin receptor

Protein Summary
Description
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356495
  • ENSP00000348888
  • ENSG00000162896
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
PubMedID
0.78
cellular component
0.68
disease perturbation
0.68
virus perturbation
0.68


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 452.64   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 468   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 452.64   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polymeric immunoglobulin receptor
VGNC:6133
457685
Macaque
polymeric immunoglobulin receptor
694638
Mouse
MGI:103080
18703
Rat
RGD:3328
25046
Dog
polymeric immunoglobulin receptor
VGNC:44540
474357
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polymeric immunoglobulin receptor
Macaque
polymeric immunoglobulin receptor
Mouse
Rat
Dog
polymeric immunoglobulin receptor
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (131)
1 – 10 of 131
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.99999956
p_ni: 3.41e-7
p_wrong: 9.8e-8
Data Source: BioPlex
FRMD1
Tdark
Novelty: 0.96833141
p_int: 0.999947246
p_ni: 0.000052753
Data Source: BioPlex
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999820282
p_ni: 0.000179717
p_wrong: 1e-9
Score: 0.231
Data Source: BioPlex,STRINGDB
HBM
Tdark
Novelty: 0.02658671
p_int: 0.999691918
p_ni: 0.000308078
p_wrong: 5e-9
Data Source: BioPlex
GTF2B
Tbio
Novelty: 0.00179492
p_int: 0.999668188
p_ni: 0.000331802
p_wrong: 1e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
ICE2
Tbio
Novelty: 0.03407933
p_int: 0.999562364
p_ni: 0.000437632
p_wrong: 4e-9
Data Source: BioPlex
NPB
Tdark
Novelty: 0.00936692
p_int: 0.999186358
p_ni: 0.000813637
p_wrong: 5e-9
Data Source: BioPlex
TMEM237
Tdark
Novelty: 0.27005874
p_int: 0.995880052
p_ni: 0.004072866
p_wrong: 0.000047081
Score: 0.183
Data Source: BioPlex,STRINGDB
ZNF491
Tdark
Family: TF
Novelty: 4.75862069
p_int: 0.995785599
p_ni: 0.004214362
p_wrong: 3.9e-8
Score: 0.175
Data Source: BioPlex,STRINGDB
ITPRID2
Tbio
Novelty: 0.07923791
p_int: 0.995496176
p_ni: 0.004503798
p_wrong: 2.7e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  452.64

PubMed score by year
PubTator Score  143.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer