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Tbio
CD8A
T-cell surface glycoprotein CD8 alpha chain

Protein Summary
Description
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283635
  • ENSP00000283635
  • ENSG00000153563
  • ENST00000352580
  • ENSP00000321631
  • ENST00000409511
  • ENSP00000386559

Symbol
  • MAL
  • CD8
  • p32
  • Leu2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.82
biological term
0.81
PubMedID
0.75
histone modification site profile
0.71
cell type or tissue
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41647.4   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 4726   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41647.4   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 4726   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD8a molecule
VGNC:188
735755
Macaque
CD8a molecule
698329
Mouse
MGI:88346
12525
Rat
RGD:2316
24930
Dog
CD8a molecule
VGNC:38980
403157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD8a molecule
Macaque
CD8a molecule
Mouse
Rat
Dog
CD8a molecule
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01732-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (87)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (182)
1 – 10 of 182
CD8B
Tbio
Novelty: 0.00382722
Score: 0.996
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.994
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  41647.40

PubMed score by year
PubTator Score  16782.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer