Tclin CD4 T-cell surface glycoprotein CD4

Protein Summary

Description

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed:2214026, PubMed:16331979, PubMed:9641677, PubMed:12089508). Down-regulated by HIV-1 Vpu (PubMed:17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed:7909607). This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]

Uniprot Accession IDs

• P01730
• B2R737
• D3DUS5
• Q4ZGK2
• Q5U066
• Q9UDE5

Gene Name

• CD4

Ensembl ID

• ENST00000011653
• ENSP00000011653
• ENSG00000010610

Symbol

• CD4mut

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
protein domain	0.97
virus	0.89
molecular function	0.88
disease	0.83

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86883.03   (req: < 5)

Gene RIFs: 284   (req: <= 3)

Antibodies: 5688   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86883.03   (req: >= 5)

Gene RIFs: 284   (req: > 3)

Antibodies: 5688   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 56

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

ibalizumab

CD4Tclin

ANTIBODY BINDING :

Active Ligands (3)

Explore Active Ligands

1 – 3 of 3

CHEMBL506605

CD4Tclin

IC50 : 6.89

CHEMBL3143464

CD4Tclin

IC50 : 6.89

CHEMBL525803

CD4Tclin

IC50 : 6.89

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD4 molecule	VGNC:5330	450124
Macaque	CD4 molecule		713807
Mouse	CD4 antigen	MGI:88335	12504
Rat	Cd4 molecule	RGD:2306	24932
Horse	CD4 molecule	VGNC:16267	100052502

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD4 molecule
Macaque	CD4 molecule
Mouse	CD4 antigen
Rat	Cd4 molecule
Horse	CD4 molecule

Protein Structure (60 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01730-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 60

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (185)

Reactome (31)

KEGG (11)

PathwayCommons (13)

WikiPathways (130)

Adaptive Immune System (R-HSA-1280218)

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Items per page:

5

1 – 5 of 31

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Alpha-defensins	9 targets	R-HSA-1462054
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Binding and entry of HIV virion	4 targets	R-HSA-173107
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Alpha-defensins	9 targets	R-HSA-1462054
Antimicrobial peptides	89 targets	R-HSA-6803157
Binding and entry of HIV virion	4 targets	R-HSA-173107
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825

Gene Ontology Terms (65)

Functions (15)

Components (9)

Processes (41)

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Items per page:

10

1 – 10 of 15

GO Term	Evidence	Assigned by
interleukin-16 receptor activity	Inferred from Direct Assay (IDA)	CAFA
MHC class II protein binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
zinc ion binding	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
interleukin-16 binding	Inferred from Physical Interaction (IPI)	CAFA
protein kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
protein tyrosine kinase binding	Inferred from Physical Interaction (IPI)	UniProtKB
coreceptor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (343)

Explore Interacting Targets

1 – 10 of 343

• See Interactions on String-DB

KIAA0319L

Tbio

Novelty: 0.02873675

p_int: 0.993327496

p_ni: 0.006655012

p_wrong: 0.000017492

Data Source: BioPlex

POGZ

Tbio

Novelty: 0.03603188

p_int: 0.992524011

p_ni: 0.007475889

p_wrong: 9.9e-8

Score: 0.187

Data Source: BioPlex,STRINGDB

TMEM11

Tbio

Novelty: 0.00067837

p_int: 0.963109631

p_ni: 0.02089222

p_wrong: 0.015998148

Score: 0.292

Data Source: BioPlex,STRINGDB

ATP6V0A2

Tbio

Family: Enzyme

Novelty: 0.00504614

p_int: 0.95437548

p_ni: 0.04562452

Data Source: BioPlex

CCDC85C

Tdark

Novelty: 0.30053883

p_int: 0.930452032

p_ni: 0.069547968

Data Source: BioPlex

ARV1

Tbio

Novelty: 0.03235632

p_int: 0.900144953

p_ni: 0.099765879

p_wrong: 0.000089168

Score: 0.185

Data Source: BioPlex,STRINGDB

VAMP3

Tbio

Novelty: 0.00694332

p_int: 0.882464048

p_ni: 0.117535914

p_wrong: 3.8e-8

Score: 0.91

Data Source: BioPlex,STRINGDB

ATP6V0A1

Tbio

Family: Enzyme

Novelty: 0.02009317

p_int: 0.879716363

p_ni: 0.120283637

Data Source: BioPlex

EIF2B3

Tbio

Novelty: 0.04963646

p_int: 0.818811552

p_ni: 0.181188448

Data Source: BioPlex

SAAL1

Tdark

Novelty: 0.33089811

p_int: 0.810497501

p_ni: 0.189502499

Data Source: BioPlex

Publication Statistics

PubMed Score  86883.03

PubMed score by year

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PubTator Score  38376.69

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Adaptive immunity
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Immunity

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype