Tclin IL2RA Interleukin-2 receptor subunit alpha

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-2 Receptor Subunit Alpha

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Interleukin-2 Receptor Subunit Alpha

Protein Summary

Description

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• P01589
• Q5W007
• IL-2 receptor subunit alpha

Gene Name

• IL2RA

Ensembl ID

• ENST00000379959
• ENSP00000369293
• ENSG00000134460

Symbol

• p55
• CD25
• IL2R
• IMD41
• TCGFR
• IDDM10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease	0.96
trait	0.93
biological process	0.79
chemical	0.79
phenotype	0.77

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.64   (req: < 5)

Gene RIFs: 367   (req: <= 3)

Antibodies: 2753   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.64   (req: >= 5)

Gene RIFs: 367   (req: > 3)

Antibodies: 2753   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

Approved Drugs (4)

Explore Approved Drugs

1 – 4 of 4

aldesleukin

IL2RATclin

AGONIST :

daclizumab

IL2RATclin

ANTIBODY BINDING Kd: 8

denileukin diftitox

IL2RATclin

ANTIBODY BINDING :

basiliximab

IL2RATclin

ANTIBODY BINDING Kd: 10

Protein Data Bank (7)

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (209)

Reactome (18)

KEGG (11)

PathwayCommons (15)

WikiPathways (165)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	FLT3 Signaling	264 targets	R-HSA-9607240
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
FLT3 Signaling	264 targets	R-HSA-9607240
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (25)

Functions (3)

Components (3)

Processes (19)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
interleukin-2 binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
interleukin-2 receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
Ras guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (320)

Explore Interacting Targets

1 – 10 of 320

• See Interactions on String-DB

IL2

Tchem

Novelty: 0.00004362

Score: 0.999

Data Source: Reactome,STRINGDB

IL2RB

Tclin

Novelty: 0.00753505

Score: 0.996

Data Source: Reactome,STRINGDB

IL2RG

Tclin

Novelty: 0.00155443

Score: 0.994

Data Source: Reactome,STRINGDB

STAT5B

Tchem

Family: TF

Novelty: 0.00091216

Score: 0.987

Data Source: STRINGDB

FOXP3

Tbio

Family: TF

Novelty: 0.00020363

Score: 0.984

Data Source: STRINGDB

STAT5A

Tchem

Family: TF

Novelty: 0.00091229

Score: 0.979

Data Source: STRINGDB

CSF2

Tbio

Novelty: 0.00012299

Score: 0.977

Data Source: STRINGDB

JAK3

Tclin

Family: Kinase

Novelty: 0.00219647

Score: 0.967

Data Source: Reactome,STRINGDB

STAT3

Tchem

Family: TF

Novelty: 0.00013496

Score: 0.966

Data Source: STRINGDB

IL5

Tclin

Novelty: 0.00032832

Score: 0.965

Data Source: STRINGDB

Publication Statistics

PubMed Score  984.64

PubMed score by year

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PubTator Score  3767.12

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGN

1-70

SSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIY

70-140

HFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESE

140-210

TSCLVTTTDFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI

210-272

MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI

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Uniprot Keyword

3D-structure
Complete proteome
Diabetes mellitus
Disease mutation
Disulfide bond
Glycoprotein
Immunity
Membrane
Polymorphism
Receptor