IL2RA
Interleukin-2 receptor subunit alpha
Protein Summary
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
- ENST00000379959
- ENSP00000369293
- ENSG00000134460
- p55
- CD25
- IL2R
- IMD41
- TCGFR
- IDDM10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.96 | ||
trait | 0.93 | ||
biological process | 0.79 | ||
chemical | 0.79 | ||
phenotype | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1140.37 (req: < 5)
Gene RIFs: 367 (req: <= 3)
Antibodies: 2753 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1140.37 (req: >= 5)
Gene RIFs: 367 (req: > 3)
Antibodies: 2753 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (0)
Protein-Protein Interactions (320)
Nearest Tclin Targets
Pathways (209)
Reactome (18)
KEGG (11)
PathwayCommons (15)
WikiPathways (165)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (3)
Components (3)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 9 | 0 | 1.2 | 98.6 | |||||
lymphocyte count | 3 | 3 | 4 | 95.2 | |||||
3 | 4 | 0 | 1.6 | 95 | |||||
7 | 4 | 0 | 1.1 | 92.7 | |||||
interleukin 2 receptor antagonist measurement | 1 | 2 | 2 | 91.7 | |||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 98.6 | |||||
lymphocyte count | 4 | 95.2 | |||||
0 | 1.6 | 95 | |||||
0 | 1.1 | 92.7 | |||||
interleukin 2 receptor antagonist measurement | 2 | 91.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 2 receptor subunit alpha | VGNC:7232 | 450884 | |||||
Macaque | interleukin 2 receptor subunit alpha | 574300 | ||||||
Mouse | MGI:96549 | 16184 | ||||||
Rat | RGD:2895 | 25704 | ||||||
Dog | interleukin 2 receptor subunit alpha | VGNC:41977 | 403870 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 2 receptor subunit alpha | |||||
Macaque | interleukin 2 receptor subunit alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 2 receptor subunit alpha | |||||
Publication Statistics
PubMed Score 1140.37
PubMed score by year
PubTator Score 3767.12
PubTator score by year
Related Publications
Text Mined References (476)
GeneRif Annotations (367)
Items per page:
0 of 0
PMID | Year | Title |
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