IL2RA
Interleukin-2 receptor subunit alpha
Protein Classes
Protein Summary
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
- ENST00000379959
- ENSP00000369293
- ENSG00000134460
- p55
- CD25
- IL2R
- IMD41
- TCGFR
- IDDM10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.96 | ||
trait | 0.93 | ||
biological process | 0.79 | ||
chemical | 0.79 | ||
phenotype | 0.77 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1140.37 (req: < 5)
Gene RIFs: 367 (req: <= 3)
Antibodies: 2753 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1140.37 (req: >= 5)
Gene RIFs: 367 (req: > 3)
Antibodies: 2753 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
8 | 9 | 0 | 1.2 | 98.6 | |||||
lymphocyte count | 3 | 3 | 4 | 95.2 | |||||
3 | 4 | 0 | 1.6 | 95 | |||||
7 | 4 | 0 | 1.1 | 92.7 | |||||
interleukin 2 receptor antagonist measurement | 1 | 2 | 2 | 91.7 | |||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 98.6 | |||||
lymphocyte count | 4 | 95.2 | |||||
0 | 1.6 | 95 | |||||
0 | 1.1 | 92.7 | |||||
interleukin 2 receptor antagonist measurement | 2 | 91.7 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 2 receptor subunit alpha | VGNC:7232 | 450884 | |||||
Macaque | interleukin 2 receptor subunit alpha | 574300 | ||||||
Mouse | MGI:96549 | 16184 | ||||||
Rat | RGD:2895 | 25704 | ||||||
Dog | interleukin 2 receptor subunit alpha | VGNC:41977 | 403870 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 2 receptor subunit alpha | |||||
Macaque | interleukin 2 receptor subunit alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 2 receptor subunit alpha | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (209)
Reactome (18)
KEGG (11)
PathwayCommons (15)
WikiPathways (165)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 18
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Gene Ontology Terms (25)
Functions (3)
Components (3)
Processes (19)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (320)
1 – 10 of 320
IL2
Novelty: 0.00003129
Score: 0.999
Data Source: Reactome,STRINGDB
IL2RB
Novelty: 0.0050905
Score: 0.996
Data Source: Reactome,STRINGDB
IL2RG
Novelty: 0.00108272
Score: 0.994
Data Source: Reactome,STRINGDB
STAT5B
Family: TF
Novelty: 0.00074178
Score: 0.987
Data Source: STRINGDB
FOXP3
Family: TF
Novelty: 0.00017205
Score: 0.984
Data Source: STRINGDB
STAT5A
Family: TF
Novelty: 0.00074026
Score: 0.979
Data Source: STRINGDB
CSF2
Novelty: 0.00010437
Score: 0.977
Data Source: STRINGDB
JAK3
Family: Kinase
Novelty: 0.00164278
Score: 0.967
Data Source: Reactome,STRINGDB
STAT3
Family: TF
Novelty: 0.00011808
Score: 0.966
Data Source: STRINGDB
IL5
Novelty: 0.0001684
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score 1140.37
PubMed score by year
PubTator Score 3767.12
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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MGI Phenotype
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