IL2RA
Interleukin-2 receptor subunit alpha
Protein Classes
Protein Summary
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
- ENST00000379959
- ENSP00000369293
- ENSG00000134460
- p55
- CD25
- IL2R
- IMD41
- TCGFR
- IDDM10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.96 | ||
trait | 0.93 | ||
biological process | 0.79 | ||
chemical | 0.79 | ||
phenotype | 0.77 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1121.85 (req: < 5)
Gene RIFs: 367 (req: <= 3)
Antibodies: 2753 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1121.85 (req: >= 5)
Gene RIFs: 367 (req: > 3)
Antibodies: 2753 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
7 | 7 | 0 | 1.2 | 99.5 | |||||
Eczema | 3 | 2 | 0 | 1.2 | 97.5 | ||||
2 | 2 | 0 | 1.1 | 97.5 | |||||
3 | 3 | 0 | 1.6 | 96.4 | |||||
7 | 3 | 0 | 1.2 | 96 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 99.5 | |||||
Eczema | 0 | 1.2 | 97.5 | ||||
0 | 1.1 | 97.5 | |||||
0 | 1.6 | 96.4 | |||||
0 | 1.2 | 96 | |||||
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (209)
Reactome (18)
KEGG (11)
PathwayCommons (15)
WikiPathways (165)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 18
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Gene Ontology Terms (25)
Functions (3)
Components (3)
Processes (19)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (320)
1 – 10 of 320
IL2
Novelty: 0.00003129
Score: 0.999
Data Source: Reactome,STRINGDB
IL2RB
Novelty: 0.0050905
Score: 0.996
Data Source: Reactome,STRINGDB
IL2RG
Novelty: 0.00108272
Score: 0.994
Data Source: Reactome,STRINGDB
STAT5B
Family: TF
Novelty: 0.00074178
Score: 0.987
Data Source: STRINGDB
FOXP3
Family: TF
Novelty: 0.00017205
Score: 0.984
Data Source: STRINGDB
STAT5A
Family: TF
Novelty: 0.00074026
Score: 0.979
Data Source: STRINGDB
CSF2
Novelty: 0.00010437
Score: 0.977
Data Source: STRINGDB
JAK3
Family: Kinase
Novelty: 0.00164278
Score: 0.967
Data Source: Reactome,STRINGDB
STAT3
Family: TF
Novelty: 0.00011808
Score: 0.966
Data Source: STRINGDB
IL5
Novelty: 0.0001684
Score: 0.965
Data Source: STRINGDB
Publication Statistics
PubMed Score 1121.85
PubMed score by year
PubTator Score 3767.12
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword
GWAS Trait
MGI Phenotype