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Tclin
IL2RA
Interleukin-2 receptor subunit alpha

Protein Summary
Description
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379959
  • ENSP00000369293
  • ENSG00000134460

Symbol
  • p55
  • CD25
  • IL2R
  • IMD41
  • TCGFR
  • IDDM10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.96
trait
0.93
biological process
0.79
chemical
0.79
phenotype
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1140.37   (req: < 5)
Gene RIFs: 367   (req: <= 3)
Antibodies: 2753   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1140.37   (req: >= 5)
Gene RIFs: 367   (req: > 3)
Antibodies: 2753   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
9
0
1.2
98.6
lymphocyte count
3
3
4
95.2
3
4
0
1.6
95
7
4
0
1.1
92.7
interleukin 2 receptor antagonist measurement
1
2
2
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.6
lymphocyte count
4
95.2
0
1.6
95
0
1.1
92.7
interleukin 2 receptor antagonist measurement
2
91.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 2 receptor subunit alpha
VGNC:7232
450884
Macaque
interleukin 2 receptor subunit alpha
574300
Mouse
MGI:96549
16184
Rat
RGD:2895
25704
Dog
interleukin 2 receptor subunit alpha
VGNC:41977
403870
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 2 receptor subunit alpha
Macaque
interleukin 2 receptor subunit alpha
Mouse
Rat
Dog
interleukin 2 receptor subunit alpha
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01589-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (209)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Protein-Protein Interactions (320)
1 – 10 of 320
IL2
Tchem
Novelty:  0.00003129
Score:  0.999
Data Source:  Reactome,STRINGDB
IL2RB
Tclin
Novelty:  0.0050905
Score:  0.996
Data Source:  Reactome,STRINGDB
IL2RG
Tclin
Novelty:  0.00108272
Score:  0.994
Data Source:  Reactome,STRINGDB
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
Score:  0.987
Data Source:  STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
Score:  0.984
Data Source:  STRINGDB
STAT5A
Tchem
Family:  TF
Novelty:  0.00074026
Score:  0.979
Data Source:  STRINGDB
CSF2
Tbio
Novelty:  0.00010437
Score:  0.977
Data Source:  STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.967
Data Source:  Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.966
Data Source:  STRINGDB
IL5
Tclin
Novelty:  0.0001684
Score:  0.965
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1140.37

PubMed score by year
PubTator Score  3767.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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