Protein Summary
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective ac ...more
- ENST00000252723
- ENSP00000252723
- ENSG00000130427
- EP
- DBAL
- ECYT5
- MVCD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 0.87 | ||
protein domain | 0.73 | ||
disease | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6858.96 (req: < 5)
Gene RIFs: 334 (req: <= 3)
Antibodies: 1198 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6858.96 (req: >= 5)
Gene RIFs: 334 (req: > 3)
Antibodies: 1198 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 43
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (300)
B4GALT5
Family: Enzyme
Novelty: 0.04538678
p_int: 0.99149806
p_ni: 0.008490928
p_wrong: 0.000011012
Data Source: BioPlex
PTPRS
Family: Enzyme
Novelty: 0.00587115
p_int: 0.98206486
p_ni: 0.01793514
Score: 0.212
Data Source: BioPlex,STRINGDB
EPOR
Novelty: 0.00134388
p_int: 0.966331816
p_ni: 7.7e-8
p_wrong: 0.033668107
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
B4GALT6
Family: Enzyme
Novelty: 0.08523889
p_int: 0.963169914
p_ni: 0.013917319
p_wrong: 0.022912767
Data Source: BioPlex
KIAA0319L
Novelty: 0.02873675
p_int: 0.89913845
p_ni: 0.100842596
p_wrong: 0.000018955
Data Source: BioPlex
GINM1
Novelty: 1.0701107
p_int: 0.785575679
p_ni: 0.00125583
p_wrong: 0.21316849
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (17)
Downstream (17)
1 – 5 of 17
Pathways (34)
Reactome (10)
KEGG (6)
PathwayCommons (12)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular response to hypoxia | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | ||||
Reactome | Erythropoietin activates Phospholipase C gamma (PLCG) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular response to hypoxia | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) | ||||
Erythropoietin activates Phospholipase C gamma (PLCG) | ||||
Viral Interactions (0)
Gene Ontology Terms (47)
Functions (4)
Components (4)
Processes (39)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hematocrit | 8 | 13 | 17 | 99.6 | |||||
hemoglobin measurement | 4 | 10 | 15 | 99.5 | |||||
mean corpuscular hemoglobin concentration | 6 | 5 | 6 | 99.3 | |||||
red blood cell distribution width | 4 | 5 | 9 | 99 | |||||
erythrocyte count | 7 | 6 | 9 | 98.7 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hematocrit | 17 | 99.6 | |||||
hemoglobin measurement | 15 | 99.5 | |||||
mean corpuscular hemoglobin concentration | 6 | 99.3 | |||||
red blood cell distribution width | 9 | 99 | |||||
erythrocyte count | 9 | 98.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | erythropoietin | VGNC:4340 | 463609 | |||||
Macaque | erythropoietin | 719294 | ||||||
Mouse | MGI:95407 | 13856 | ||||||
Rat | RGD:2559 | 24335 | ||||||
Dog | erythropoietin | VGNC:40422 | 404002 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | erythropoietin | |||||
Macaque | erythropoietin | |||||
Mouse | ||||||
Rat | ||||||
Dog | erythropoietin | |||||
Publication Statistics
PubMed Score 6858.96
PubMed score by year
PubTator Score 15502.39
PubTator score by year
Related Publications
Text Mined References (377)
GeneRif Annotations (334)
Items per page:
0 of 0
PMID | Year | Title |
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