Tbio EPO Erythropoietin

Protein Summary

Description

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P01588
• Q2M2L6
• Q549U2
• Q9UDZ0
• Q9UEZ5
• Q9UHA0

Gene Name

• EPO

Ensembl ID

• ENST00000252723
• ENSP00000252723
• ENSG00000130427

Symbol

• EP
• DBAL
• ECYT5
• MVCD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	0.87
protein domain	0.73
disease	0.68

Protein Classes

DTO Classes

Erythropoietin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6858.96   (req: < 5)

Gene RIFs: 334   (req: <= 3)

Antibodies: 1198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6858.96   (req: >= 5)

Gene RIFs: 334   (req: > 3)

Antibodies: 1198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (300)

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1 – 10 of 300

• See Interactions on String-DB

B4GALT5

Tbio

Family:  Enzyme

Novelty:  0.04538678

p_int:  0.99149806

p_ni:  0.008490928

p_wrong:  0.000011012

Data Source:  BioPlex

PTPRS

Tchem

Family:  Enzyme

Novelty:  0.00587115

p_int:  0.98206486

p_ni:  0.01793514

Score:  0.212

Data Source:  BioPlex,STRINGDB

EPOR

Tclin

Novelty:  0.00134388

p_int:  0.966331816

p_ni:  7.7e-8

p_wrong:  0.033668107

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

B4GALT6

Tbio

Family:  Enzyme

Novelty:  0.08523889

p_int:  0.963169914

p_ni:  0.013917319

p_wrong:  0.022912767

Data Source:  BioPlex

KIAA0319L

Tbio

Novelty:  0.02873675

p_int:  0.89913845

p_ni:  0.100842596

p_wrong:  0.000018955

Data Source:  BioPlex

GINM1

Tdark

Novelty:  1.0701107

p_int:  0.785575679

p_ni:  0.00125583

p_wrong:  0.21316849

Score:  0.189

Data Source:  BioPlex,STRINGDB

JAK2

Tclin

Family:  Kinase

Novelty:  0.00022894

Score:  0.988

Data Source:  Reactome,STRINGDB

HIF1A

Tchem

Family:  TF

Novelty:  0.00011503

Score:  0.984

Data Source:  STRINGDB

KITLG

Tbio

Novelty:  0.00036337

Score:  0.984

Data Source:  STRINGDB

CSF3

Tbio

Novelty:  0.00011283

Score:  0.981

Data Source:  STRINGDB

Nearest Tclin Targets (17)

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Downstream (17)

1 – 5 of 17

IFNAR1

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  4

1: PI3K-Akt signaling pathway

2: JAK-STAT signaling pathway

3: Pathways in cancer

4: Cytokine-cytokine receptor interaction

CSF3R

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  5

1: PI3K-Akt signaling pathway

2: JAK-STAT signaling pathway

3: Pathways in cancer

4: Hematopoietic cell lineage

5: Cytokine-cytokine receptor interaction

IL2RG

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  4

1: PI3K-Akt signaling pathway

2: JAK-STAT signaling pathway

3: Pathways in cancer

4: Cytokine-cytokine receptor interaction

IL2RB

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  4

1: PI3K-Akt signaling pathway

2: JAK-STAT signaling pathway

3: Pathways in cancer

4: Cytokine-cytokine receptor interaction

IL6R

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  6

1: PI3K-Akt signaling pathway

2: HIF-1 signaling pathway

3: JAK-STAT signaling pathway

4: Pathways in cancer

more:  2 more common pathways

Pathways (34)

Reactome (10)

KEGG (6)

PathwayCommons (12)

WikiPathways (6)

Cellular response to hypoxia (R-HSA-1234174)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular response to hypoxia	76 targets	R-HSA-1234174
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12 targets	R-HSA-9027276
Reactome	Erythropoietin activates Phospholipase C gamma (PLCG)	7 targets	R-HSA-9027277

Name	Explore in Pharos	Explore in Source
Cellular response to hypoxia	76 targets	R-HSA-1234174
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)	12 targets	R-HSA-9027276
Erythropoietin activates Phospholipase C gamma (PLCG)	7 targets	R-HSA-9027277

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (47)

Functions (4)

Components (4)

Processes (39)

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1 – 4 of 4

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Direct Assay (IDA)	BHF-UCL
erythropoietin receptor binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
protein kinase activator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
hormone activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (33)

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1 – 5 of 33

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	8	13	17		99.6
hemoglobin measurement	EFO_0004509	4	10	15		99.5
mean corpuscular hemoglobin concentration	EFO_0004528	6	5	6		99.3
red blood cell distribution width	EFO_0005192	4	5	9		99
erythrocyte count	EFO_0004305	7	6	9		98.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 33

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hematocrit	EFO_0004348	17		99.6
hemoglobin measurement	EFO_0004509	15		99.5
mean corpuscular hemoglobin concentration	EFO_0004528	6		99.3
red blood cell distribution width	EFO_0005192	9		99
erythrocyte count	EFO_0004305	9		98.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Congenital erythrocytosis
Direct protein sequencing
Disease mutation
Disulfide bond
Erythrocyte maturation
Glycoprotein
Hormone
Pharmaceutical

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
autoimmune thyroid disease
BMI-adjusted waist circumference
eosinophil count
erythrocyte count
erythrocyte measurement
glucose measurement
hair color
HbA1c measurement
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
limbs/digits/tail phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	erythropoietin	VGNC:4340	463609
Macaque	erythropoietin		719294
Mouse	erythropoietin	MGI:95407	13856
Rat	erythropoietin	RGD:2559	24335
Dog	erythropoietin	VGNC:40422	404002

Species	Name	OMA	EggNOG	Inparanoid
Chimp	erythropoietin
Macaque	erythropoietin
Mouse	erythropoietin
Rat	erythropoietin
Dog	erythropoietin

Publication Statistics

PubMed Score 6858.96

PubMed score by year

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PubTator Score 15502.39

PubTator score by year

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Related Publications

Text Mined References (377)

GeneRif Annotations (334)

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PMID	Year	Title