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Tbio
EPO
Erythropoietin

Protein Summary
Description
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective ac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252723
  • ENSP00000252723
  • ENSG00000130427

Symbol
  • EP
  • DBAL
  • ECYT5
  • MVCD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
0.87
protein domain
0.73
disease
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6858.96   (req: < 5)
Gene RIFs: 334   (req: <= 3)
Antibodies: 1198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6858.96   (req: >= 5)
Gene RIFs: 334   (req: > 3)
Antibodies: 1198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (300)
B4GALT5
Tbio
Family:  Enzyme
Novelty:  0.04538678
p_int:  0.99149806
p_ni:  0.008490928
p_wrong:  0.000011012
Data Source:  BioPlex
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
p_int:  0.98206486
p_ni:  0.01793514
Score:  0.212
Data Source:  BioPlex,STRINGDB
EPOR
Tclin
Novelty:  0.00134388
p_int:  0.966331816
p_ni:  7.7e-8
p_wrong:  0.033668107
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
B4GALT6
Tbio
Family:  Enzyme
Novelty:  0.08523889
p_int:  0.963169914
p_ni:  0.013917319
p_wrong:  0.022912767
Data Source:  BioPlex
KIAA0319L
Tbio
Novelty:  0.02873675
p_int:  0.89913845
p_ni:  0.100842596
p_wrong:  0.000018955
Data Source:  BioPlex
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.785575679
p_ni:  0.00125583
p_wrong:  0.21316849
Score:  0.189
Data Source:  BioPlex,STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.988
Data Source:  Reactome,STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.984
Data Source:  STRINGDB
KITLG
Tbio
Novelty:  0.00036337
Score:  0.984
Data Source:  STRINGDB
CSF3
Tbio
Novelty:  0.00011283
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (34)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Reactome
Erythropoietin activates Phospholipase C gamma (PLCG)
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
8
13
17
99.6
hemoglobin measurement
4
10
15
99.5
mean corpuscular hemoglobin concentration
6
5
6
99.3
red blood cell distribution width
4
5
9
99
erythrocyte count
7
6
9
98.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
17
99.6
hemoglobin measurement
15
99.5
mean corpuscular hemoglobin concentration
6
99.3
red blood cell distribution width
9
99
erythrocyte count
9
98.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
erythropoietin
VGNC:4340
463609
Macaque
erythropoietin
719294
Mouse
MGI:95407
13856
Rat
RGD:2559
24335
Dog
erythropoietin
VGNC:40422
404002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
erythropoietin
Macaque
erythropoietin
Mouse
Rat
Dog
erythropoietin
Publication Statistics
PubMed Score 6858.96
PubMed score by year
PubTator Score 15502.39
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title