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Tclin
IL1B
Interleukin-1 beta

Protein Summary
Description
Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263341
  • ENSP00000263341
  • ENSG00000125538

Symbol
  • IL1F2
  • IL-1
  • IL1F2
  • IL1-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
gene perturbation
1
small molecule perturbation
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33804.41   (req: < 5)
Gene RIFs: 1854   (req: <= 3)
Antibodies: 2142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33804.41   (req: >= 5)
Gene RIFs: 1854   (req: > 3)
Antibodies: 2142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 95
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
rilonacept
no chemical structure image available
canakinumab
no chemical structure image available
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
94.5
interleukin-1 beta measurement
1
31
31
93.1
neutrophil count
1
2
2
68.8
dysmenorrheic pain measurement
2
2
2
67.1
gestational age
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.5
interleukin-1 beta measurement
31
93.1
neutrophil count
2
68.8
dysmenorrheic pain measurement
2
67.1
gestational age
1
60.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 beta
VGNC:1940
450200
Mouse
MGI:96543
16176
Rat
RGD:2891
24494
Dog
interleukin 1 beta
VGNC:41957
403974
Cow
interleukin 1 beta
VGNC:52787
281251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 beta
Mouse
Rat
Dog
interleukin 1 beta
Cow
interleukin 1 beta
Protein Structure (32 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01584-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 32
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (120)
C-type lectin receptors (CLRs) (R-HSA-5621481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
CLEC7A/inflammasome pathway
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
CLEC7A/inflammasome pathway
Cytokine Signaling in Immune system
Immune System
Protein-Protein Interactions (604)
1 – 10 of 604
IL1R1
Tclin
Novelty:  0.0014281
Score:  0.998
Data Source:  Reactome,STRINGDB
IL1RAP
Tclin
Novelty:  0.01115915
Score:  0.997
Data Source:  Reactome,STRINGDB
IL1R2
Tbio
Novelty:  0.00820359
Score:  0.997
Data Source:  Reactome,STRINGDB
IL1A
Tchem
Novelty:  0.00019366
Score:  0.997
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.996
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.996
Data Source:  Reactome,STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.992
Data Source:  STRINGDB
IL18
Tbio
Novelty:  0.00022844
Score:  0.992
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.991
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.989
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33804.41

PubMed score by year
PubTator Score  12821.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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