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Tchem
IL1A
Interleukin-1 alpha

Protein Summary
Description
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263339
  • ENSP00000263339
  • ENSG00000115008

Symbol
  • IL1F1
  • IL1
  • IL-1A
  • IL1F1
  • IL1-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
gene perturbation
1
biological process
0.98
virus perturbation
0.9
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4995.83   (req: < 5)
Gene RIFs: 473   (req: <= 3)
Antibodies: 1335   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4995.83   (req: >= 5)
Gene RIFs: 473   (req: > 3)
Antibodies: 1335   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
rilonacept
no chemical structure image available
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dysmenorrheic pain measurement
2
2
2
46.3
neutrophil count
1
1
1
34.5
quality of life during menstruation measurement
2
2
2
33.6
neutrophil percentage of leukocytes
1
1
1
15.7
drug use measurement
1
1
1
15
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
dysmenorrheic pain measurement
2
46.3
neutrophil count
1
34.5
quality of life during menstruation measurement
2
33.6
neutrophil percentage of leukocytes
1
15.7
drug use measurement
1
15
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 alpha
VGNC:1939
470485
Macaque
interleukin 1 alpha
700193
Mouse
MGI:96542
16175
Rat
RGD:2890
24493
Dog
interleukin 1 alpha
VGNC:41956
403782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 1 alpha
Macaque
interleukin 1 alpha
Mouse
Rat
Dog
interleukin 1 alpha
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (70)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Immune System
Gene Ontology Terms (29)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (179)
1 – 10 of 179
IL1B
Tclin
Novelty: 0.0000308
Score: 0.997
Data Source: STRINGDB
IL1R1
Tclin
Novelty: 0.0014281
Score: 0.989
Data Source: Reactome,STRINGDB
IL1RN
Tchem
Novelty: 0.00070533
Score: 0.988
Data Source: STRINGDB
IL1R2
Tbio
Novelty: 0.00820359
Score: 0.978
Data Source: Reactome,STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.973
Data Source: STRINGDB
IL4
Tbio
Novelty: 0.00005852
Score: 0.972
Data Source: STRINGDB
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.97
Data Source: STRINGDB
IL18
Tbio
Novelty: 0.00022844
Score: 0.966
Data Source: STRINGDB
IL1RAP
Tclin
Novelty: 0.01115915
Score: 0.963
Data Source: Reactome,STRINGDB
IL13
Tbio
Novelty: 0.00021435
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  4995.83

PubMed score by year
PubTator Score  7874.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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