Protein Summary
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2 ...more
- ENST00000263339
- ENSP00000263339
- ENSG00000115008
- IL1F1
- IL1
- IL-1A
- IL1F1
- IL1-ALPHA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
gene perturbation | 1 | ||
biological process | 0.98 | ||
virus perturbation | 0.9 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5076.97 (req: < 5)
Gene RIFs: 473 (req: <= 3)
Antibodies: 1335 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5076.97 (req: >= 5)
Gene RIFs: 473 (req: > 3)
Antibodies: 1335 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (179)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (70)
Reactome (12)
KEGG (20)
PathwayCommons (17)
WikiPathways (21)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (3)
Components (3)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 3 | 94.5 | |||||
interleukin-1 beta measurement | 1 | 17 | 17 | 90.7 | |||||
neutrophil count | 1 | 2 | 2 | 68.8 | |||||
dysmenorrheic pain measurement | 2 | 2 | 2 | 67.1 | |||||
gestational age | 1 | 1 | 1 | 60.5 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 94.5 | |||||
interleukin-1 beta measurement | 17 | 90.7 | |||||
neutrophil count | 2 | 68.8 | |||||
dysmenorrheic pain measurement | 2 | 67.1 | |||||
gestational age | 1 | 60.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 1 alpha | VGNC:1939 | 470485 | |||||
Macaque | interleukin 1 alpha | 700193 | ||||||
Mouse | MGI:96542 | 16175 | ||||||
Rat | RGD:2890 | 24493 | ||||||
Dog | interleukin 1 alpha | VGNC:41956 | 403782 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 1 alpha | |||||
Macaque | interleukin 1 alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 1 alpha | |||||
Publication Statistics
PubMed Score 5076.97
PubMed score by year
PubTator Score 7874.11
PubTator score by year
Related Publications
Text Mined References (871)
GeneRif Annotations (473)
Items per page:
0 of 0
PMID | Year | Title |
|---|