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Tbio
IFNB1
Interferon beta

Protein Summary
Description
Has antiviral, antibacterial and anticancer activities. This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380232
  • ENSP00000369581
  • ENSG00000171855

Symbol
  • IFB
  • IFNB
  • IFB
  • IFF
  • IFNB
  • IFN-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
virus perturbation
1
disease
0.78
phenotype
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8625.82   (req: < 5)
Gene RIFs: 305   (req: <= 3)
Antibodies: 932   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8625.82   (req: >= 5)
Gene RIFs: 305   (req: > 3)
Antibodies: 932   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon beta 1
VGNC:8900
473183
Macaque
interferon beta 1
711414
Mouse
MGI:107657
15977
Rat
RGD:2865
24481
Horse
Equus caballus interferon, beta 1, fibroblast (IFNB1), mRNA. [Source:RefSeq mRNA;Acc:NM_001099440]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon beta 1
Macaque
interferon beta 1
Mouse
Rat
Horse
Equus caballus interferon, beta 1, fibroblast (IFNB1), mRNA. [Source:RefSeq mRNA;Acc:NM_001099440]
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01574-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (63)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Protein-Protein Interactions (263)
1 – 10 of 263
IFNAR1
Tclin
Novelty: 0.00175488
p_int: 0.999940554
p_ni: 0.000059445
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.991
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.986
Data Source: STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.975
Data Source: Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.0003383
Score: 0.972
Data Source: Reactome,STRINGDB
IRF2
Tbio
Family: TF
Novelty: 0.00534484
Score: 0.971
Data Source: STRINGDB
SOCS1
Tbio
Novelty: 0.00131368
Score: 0.97
Data Source: Reactome,STRINGDB
IRF1
Tbio
Family: TF
Novelty: 0.00099983
Score: 0.968
Data Source: STRINGDB
STAT2
Tbio
Family: TF
Novelty: 0.00241454
Score: 0.965
Data Source: Reactome,STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.00751233
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  8625.82

PubMed score by year
PubTator Score  4266.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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