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Tbio
IFNA17
Interferon alpha-17

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000413767
  • ENSP00000411940
  • ENSG00000234829

Symbol
  • IFNA
  • INFA
  • LEIF2C1
  • IFN-alphaI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
cell type or tissue
0.73
tissue
0.62
disease
0.61
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.62   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.62   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (74)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (121)
1 – 10 of 121
IFNA1
Tbio
Novelty: 0.0000962
p_int: 0.999999298
p_ni: 2e-9
p_wrong: 7e-7
Score: 0.245
Data Source: BioPlex,STRINGDB
IFNA5
Tbio
Novelty: 0.02838784
p_int: 0.999995972
p_ni: 7.1e-8
p_wrong: 0.000003958
Score: 0.296
Data Source: BioPlex,STRINGDB
CABCOCO1
Tdark
Novelty: 0.41263041
p_int: 0.999332086
p_ni: 0.000667907
p_wrong: 8e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
C16orf54
Tdark
Novelty: 3.18165606
p_int: 0.997258353
p_ni: 0.00274139
p_wrong: 2.58e-7
Score: 0.269
Data Source: BioPlex,STRINGDB
ZNF586
Tdark
Family: TF
Novelty: 10.33879781
p_int: 0.995607809
p_ni: 0.003260237
p_wrong: 0.001131954
Score: 0.379
Data Source: BioPlex,STRINGDB
LHFPL4
Tdark
Novelty: 0.60482288
p_int: 0.995607809
p_ni: 0.003260237
p_wrong: 0.001131954
Score: 0.309
Data Source: BioPlex,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.975
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.955
Data Source: STRINGDB
IFNAR1
Tclin
Novelty: 0.00175488
Score: 0.954
Data Source: STRINGDB
IRF9
Tbio
Family: TF
Novelty: 0.00751233
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  295.62

PubMed score by year
PubTator Score  223.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer