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Tbio
IFNA14
Interferon alpha-14

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380222
  • ENSP00000369571
  • ENSG00000228083

Symbol
  • LEIF2H
  • IFN-alphaH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
co-expressed gene
0.89
biological process
0.82
small molecule perturbation
0.59
pathway
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.99   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.99   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (83)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (78)
1 – 10 of 78
IFNA1
Tbio
Novelty: 0.00013873
p_int: 0.999997627
p_ni: 7.9e-8
p_wrong: 0.000002294
Score: 0.843
Data Source: BioPlex,STRINGDB
IFIT3
Tbio
Novelty: 0.00899003
p_int: 0.999988985
p_ni: 0.00001099
p_wrong: 2.5e-8
Score: 0.845
Data Source: BioPlex,STRINGDB
IFNA5
Tbio
Novelty: 0.01718471
p_int: 0.999973778
p_ni: 0.000026008
p_wrong: 2.14e-7
Score: 0.873
Data Source: BioPlex,STRINGDB
ISG15
Tbio
Novelty: 0.00256125
p_int: 0.999744555
p_ni: 0.000232521
p_wrong: 0.000022923
Score: 0.875
Data Source: BioPlex,STRINGDB
IFIT1
Tbio
Novelty: 0.00862855
p_int: 0.999474975
p_ni: 0.000525024
p_wrong: 1e-9
Score: 0.871
Data Source: BioPlex,STRINGDB
IFNA21
Tbio
Novelty: 0.00852658
p_int: 0.999082081
p_ni: 2.7e-8
p_wrong: 0.000917892
Score: 0.982
Data Source: BioPlex,STRINGDB
IFNA6
Tbio
Novelty: 0.07133637
p_int: 0.998467302
p_ni: 0.000203693
p_wrong: 0.001329004
Score: 0.99
Data Source: BioPlex,STRINGDB
IFNAR1
Tclin
Novelty: 0.00224149
Score: 0.928
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.924
Data Source: STRINGDB
IFNA17
Tbio
Novelty: 0.00468841
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.99

PubMed score by year
PubTator Score  8.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer