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Tbio
IFNA14
Interferon alpha-14

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380222
  • ENSP00000369571
  • ENSG00000228083

Symbol
  • LEIF2H
  • IFN-alphaH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
co-expressed gene
0.89
biological process
0.82
small molecule perturbation
0.59
pathway
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
IFNA1
Tbio
Novelty:  0.0000962
p_int:  0.999997627
p_ni:  7.9e-8
p_wrong:  0.000002294
Score:  0.843
Data Source:  BioPlex,STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
p_int:  0.999988985
p_ni:  0.00001099
p_wrong:  2.5e-8
Score:  0.845
Data Source:  BioPlex,STRINGDB
IFNA5
Tbio
Novelty:  0.02838784
p_int:  0.999973778
p_ni:  0.000026008
p_wrong:  2.14e-7
Score:  0.873
Data Source:  BioPlex,STRINGDB
ISG15
Tbio
Novelty:  0.00203781
p_int:  0.999744555
p_ni:  0.000232521
p_wrong:  0.000022923
Score:  0.875
Data Source:  BioPlex,STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
p_int:  0.999474975
p_ni:  0.000525024
p_wrong:  1e-9
Score:  0.871
Data Source:  BioPlex,STRINGDB
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.999082081
p_ni:  2.7e-8
p_wrong:  0.000917892
Score:  0.982
Data Source:  BioPlex,STRINGDB
IFNA6
Tbio
Novelty:  0.06253956
p_int:  0.998467302
p_ni:  0.000203693
p_wrong:  0.001329004
Score:  0.99
Data Source:  BioPlex,STRINGDB
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.928
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.924
Data Source:  STRINGDB
IFNA17
Tbio
Novelty:  0.0030696
Score:  0.918
Data Source:  STRINGDB
Pathways (83)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
1
1
0
1.7
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
0
1.7
38.2
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 4.94
PubMed score by year
PubTator Score 8.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title