Tbio IFNA5 Interferon alpha-5

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Uniprot Accession IDs

• P01569
• Q52LX3
• IFN-alpha-5

Gene Name

• IFNA5

Ensembl ID

• ENST00000610521
• ENSP00000484479
• ENSG00000147873

Symbol

• INA5
• INFA5
• leIF G
• IFN-alphaG
• IFN-alpha-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.82
tissue sample	0.74
cell type or tissue	0.62
pathway	0.52
phenotype	0.51

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.56   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.56   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (85)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (41)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (17)

Functions (3)

Components (2)

Processes (12)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytokine receptor binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

• See Interactions on String-DB

IFNA6

Tbio

Novelty: 0.07133637

p_int: 0.999999792

p_ni: 1.99e-7

p_wrong: 1e-8

Score: 0.852

Data Source: BioPlex,STRINGDB

IFNA4

Tbio

Novelty: 0.06891704

p_int: 0.99999941

p_ni: 5.9e-7

Score: 0.833

Data Source: BioPlex,STRINGDB

IFNA17

Tbio

Novelty: 0.00468841

p_int: 0.999995972

p_ni: 7.1e-8

p_wrong: 0.000003958

Score: 0.296

Data Source: BioPlex,STRINGDB

IFNA14

Tbio

Novelty: 0.42599235

p_int: 0.999973778

p_ni: 0.000026008

p_wrong: 2.14e-7

Score: 0.873

Data Source: BioPlex,STRINGDB

IFNA1

Tbio

Novelty: 0.00013873

p_int: 0.999876354

p_ni: 0.000123646

Data Source: BioPlex

SURF1

Tbio

Novelty: 0.00865786

p_int: 0.999801713

p_ni: 0.000197778

p_wrong: 5.09e-7

Score: 0.228

Data Source: BioPlex,STRINGDB

ISG15

Tbio

Novelty: 0.00256125

p_int: 0.999739268

p_ni: 0.000202887

p_wrong: 0.000057845

Score: 0.886

Data Source: BioPlex,STRINGDB

IFNA2

Tbio

Novelty: 0.00041727

p_int: 0.999497914

p_wrong: 0.000502085

Score: 0.861

Data Source: BioPlex,STRINGDB

IFIT1

Tbio

Novelty: 0.00862855

p_int: 0.997622525

p_ni: 0.00232999

p_wrong: 0.000047485

Score: 0.772

Data Source: BioPlex,STRINGDB

UBR3

Tbio

Family: Enzyme

Novelty: 0.11338583

p_int: 0.99742976

p_ni: 0.00257024

Score: 0.217

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  51.56

PubMed score by year

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PubTator Score  34.73

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFGFPQEEFDGNQ

1-70

FQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLEACMMQEVGVEDTPLMNVDSI

70-140

LTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSANLQERLRRKE

140-189

MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFGFPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLEACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSANLQERLRRKE

Find similar targets by:

Uniprot Keyword

Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Reference proteome
Secreted
Signal