Tbio IFNA5 Interferon alpha-5

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Uniprot Accession IDs

• P01569
• Q52LX3
• IFN-alpha-5

Gene Name

• IFNA5

Ensembl ID

• ENST00000610521
• ENSP00000484479
• ENSG00000147873

Symbol

• INA5
• INFA5
• leIF G
• IFN-alphaG
• IFN-alpha-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.82
tissue sample	0.74
cell type or tissue	0.62
pathway	0.52
phenotype	0.51

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.32   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.32   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	1	2		11.7
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		11.3
epilepsy	EFO_0000474	1	1	0	10.7	7.8
maculopapular eruption	EFO_1001253	1	1	0	10.7	7.8
response to lamotrigine	EFO_0007661	1	1	0	10.7	7.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		11.7
lymphocyte percentage of leukocytes	EFO_0007993	1		11.3
epilepsy	EFO_0000474	0	10.7	7.8
maculopapular eruption	EFO_1001253	0	10.7	7.8
response to lamotrigine	EFO_0007661	0	10.7	7.8

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Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P01569-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (85)

Reactome (10)

KEGG (22)

PathwayCommons (12)

WikiPathways (41)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets

Items per page:

5

1 – 5 of 10

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77 targets	R-HSA-168928
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (17)

Functions (3)

Components (2)

Processes (12)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
cytokine activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
type I interferon receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytokine receptor binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (62)

Explore Interacting Targets

1 – 10 of 62

• See Interactions on String-DB

IFNA6

Tbio

Novelty:  0.06253956

p_int:  0.999999792

p_ni:  1.99e-7

p_wrong:  1e-8

Score:  0.852

Data Source:  BioPlex,STRINGDB

IFNA4

Tbio

Novelty:  0.04421984

p_int:  0.99999941

p_ni:  5.9e-7

Score:  0.833

Data Source:  BioPlex,STRINGDB

IFNA17

Tbio

Novelty:  0.0030696

p_int:  0.999995972

p_ni:  7.1e-8

p_wrong:  0.000003958

Score:  0.296

Data Source:  BioPlex,STRINGDB

IFNA14

Tbio

Novelty:  0.17853653

p_int:  0.999973778

p_ni:  0.000026008

p_wrong:  2.14e-7

Score:  0.873

Data Source:  BioPlex,STRINGDB

IFNA1

Tbio

Novelty:  0.0000962

p_int:  0.999876354

p_ni:  0.000123646

Data Source:  BioPlex

SURF1

Tbio

Novelty:  0.00717605

p_int:  0.999801713

p_ni:  0.000197778

p_wrong:  5.09e-7

Score:  0.228

Data Source:  BioPlex,STRINGDB

ISG15

Tbio

Novelty:  0.00203781

p_int:  0.999739268

p_ni:  0.000202887

p_wrong:  0.000057845

Score:  0.886

Data Source:  BioPlex,STRINGDB

IFNA2

Tbio

Novelty:  0.00032935

p_int:  0.999497914

p_wrong:  0.000502085

Score:  0.861

Data Source:  BioPlex,STRINGDB

IFIT1

Tbio

Novelty:  0.00562299

p_int:  0.997622525

p_ni:  0.00232999

p_wrong:  0.000047485

Score:  0.772

Data Source:  BioPlex,STRINGDB

UBR3

Tbio

Family:  Enzyme

Novelty:  0.14930754

p_int:  0.99742976

p_ni:  0.00257024

Score:  0.217

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  22.32

PubMed score by year

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PubTator Score  34.73

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Antiviral defense
Complete proteome
Cytokine
Direct protein sequencing
Disulfide bond
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
epilepsy
lymphocyte percentage of leukocytes
maculopapular eruption
neutrophil count
neutrophil percentage of leukocytes
response to lamotrigine