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Tbio
IFNA5
Interferon alpha-5

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610521
  • ENSP00000484479
  • ENSG00000147873

Symbol
  • INA5
  • INFA5
  • leIF G
  • IFN-alphaG
  • IFN-alpha-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
tissue sample
0.74
cell type or tissue
0.62
pathway
0.52
phenotype
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
11.7
lymphocyte percentage of leukocytes
1
1
1
11.3
1
1
0
10.7
7.8
maculopapular eruption
1
1
0
10.7
7.8
response to lamotrigine
1
1
0
10.7
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
11.7
lymphocyte percentage of leukocytes
1
11.3
0
10.7
7.8
maculopapular eruption
0
10.7
7.8
response to lamotrigine
0
10.7
7.8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P01569-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (85)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (62)
1 – 10 of 62
IFNA6
Tbio
Novelty:  0.06253956
p_int:  0.999999792
p_ni:  1.99e-7
p_wrong:  1e-8
Score:  0.852
Data Source:  BioPlex,STRINGDB
IFNA4
Tbio
Novelty:  0.04421984
p_int:  0.99999941
p_ni:  5.9e-7
Score:  0.833
Data Source:  BioPlex,STRINGDB
IFNA17
Tbio
Novelty:  0.0030696
p_int:  0.999995972
p_ni:  7.1e-8
p_wrong:  0.000003958
Score:  0.296
Data Source:  BioPlex,STRINGDB
IFNA14
Tbio
Novelty:  0.17853653
p_int:  0.999973778
p_ni:  0.000026008
p_wrong:  2.14e-7
Score:  0.873
Data Source:  BioPlex,STRINGDB
IFNA1
Tbio
Novelty:  0.0000962
p_int:  0.999876354
p_ni:  0.000123646
Data Source:  BioPlex
SURF1
Tbio
Novelty:  0.00717605
p_int:  0.999801713
p_ni:  0.000197778
p_wrong:  5.09e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
ISG15
Tbio
Novelty:  0.00203781
p_int:  0.999739268
p_ni:  0.000202887
p_wrong:  0.000057845
Score:  0.886
Data Source:  BioPlex,STRINGDB
IFNA2
Tbio
Novelty:  0.00032935
p_int:  0.999497914
p_wrong:  0.000502085
Score:  0.861
Data Source:  BioPlex,STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
p_int:  0.997622525
p_ni:  0.00232999
p_wrong:  0.000047485
Score:  0.772
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.99742976
p_ni:  0.00257024
Score:  0.217
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.32

PubMed score by year
PubTator Score  34.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer