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Tbio
IFNA21
Interferon alpha-21

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380225
  • ENSP00000369574
  • ENSG00000137080

Symbol
  • LeIF F
  • leIF-F
  • IFN-alphaI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
disease
0.59
tissue sample
0.58
pathway
0.52
cell line
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (49)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (17)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (125)
1 – 10 of 125
IFNA4
Tbio
Novelty: 0.04421984
p_int: 1
Score: 0.964
Data Source: BioPlex,STRINGDB
IFNA1
Tbio
Novelty: 0.0000962
p_int: 0.99999957
p_ni: 4.25e-7
p_wrong: 6e-9
Score: 0.829
Data Source: BioPlex,STRINGDB
IFNA6
Tbio
Novelty: 0.06253956
p_int: 0.999999456
p_wrong: 5.43e-7
Score: 0.982
Data Source: BioPlex,STRINGDB
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.999982215
p_ni: 0.000017664
p_wrong: 1.21e-7
Score: 0.85
Data Source: BioPlex,STRINGDB
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.999958465
p_ni: 0.000041535
Data Source: BioPlex
IFI44
Tbio
Novelty: 0.02787222
p_int: 0.999941587
p_ni: 6e-8
p_wrong: 0.000058353
Score: 0.378
Data Source: BioPlex,STRINGDB
IFI44L
Tbio
Novelty: 0.03196778
p_int: 0.999939494
p_ni: 3.53e-7
p_wrong: 0.000060153
Score: 0.337
Data Source: BioPlex,STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
p_int: 0.999612935
p_ni: 0.000365108
p_wrong: 0.000021957
Score: 0.634
Data Source: BioPlex,STRINGDB
IFNA14
Tbio
Novelty: 0.17853653
p_int: 0.999082081
p_ni: 2.7e-8
p_wrong: 0.000917892
Score: 0.982
Data Source: BioPlex,STRINGDB
PCYOX1L
Tdark
Family: Enzyme
Novelty: 1.25398886
p_int: 0.997474242
p_ni: 0.00252574
p_wrong: 1.8e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  143.80

PubMed score by year
PubTator Score  8.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer