Tbio IFNA21 Interferon alpha-21

Protein Summary

Description

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P01568
• Q14608
• Q5VWD1
• Q7M4Q4
• IFN-alpha-21

Gene Name

• IFNA21

Ensembl ID

• ENST00000380225
• ENSP00000369574
• ENSG00000137080

Symbol

• LeIF F
• leIF-F
• IFN-alphaI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.82
disease	0.59
tissue sample	0.58
pathway	0.52
cell line	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.21   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.21   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0