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Tdark
IFNA7
Interferon alpha-7

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239347
  • ENSP00000239347
  • ENSG00000214042

Symbol
  • IFNA-J
  • IFN-alphaJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.84
pathway
0.52
cell line
0.44
phenotype
0.41
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (50)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (81)
1 – 10 of 81
IFNA4
Tbio
Novelty: 0.04421984
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.966
Data Source: BioPlex,STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
p_int: 0.999961845
p_ni: 0.000025971
p_wrong: 0.000012184
Score: 0.161
Data Source: BioPlex,STRINGDB
PEX7
Tbio
Novelty: 0.01487923
p_int: 0.999739529
p_ni: 0.000255977
p_wrong: 0.000004495
Data Source: BioPlex
IFIT3
Tbio
Novelty: 0.00568113
p_int: 0.99942743
p_ni: 0.000025641
p_wrong: 0.000546929
Data Source: BioPlex
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.999266517
p_ni: 0.000733483
Data Source: BioPlex
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.997925207
p_ni: 0.000011196
p_wrong: 0.002063597
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.780785904
p_ni: 0.219214096
Data Source: BioPlex
IFNA10
Tbio
Novelty: 0.04848204
Score: 0.927
Data Source: STRINGDB
IFNAR1
Tclin
Novelty: 0.00175488
Score: 0.921
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.76

PubMed score by year
PubTator Score  6.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer