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Tbio
IFNA10
Interferon alpha-10

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. This gene encodes a protein that belongs to the type I interferon family of proteins, and is located in a cluster of alpha interferon genes on chromosome 9. Interferons are small regulatory molecules that function in cell signaling in response to viruses and other pathogens or tumor cells. This gene is intronless and the encoded protein is secreted. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357374
  • ENSP00000369566
  • ENSG00000186803

Symbol
  • IFN-alphaC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
biological process
0.82
cell line
0.56
virus perturbation
0.55
pathway
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.46   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.46   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ISG15
Tbio
Novelty:  0.00203781
p_int:  0.999863743
p_ni:  0.000136255
p_wrong:  2e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
p_int:  0.999111822
p_ni:  0.000697794
p_wrong:  0.000190384
Score:  0.354
Data Source:  BioPlex,STRINGDB
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.980595177
p_ni:  0.019404823
Score:  0.188
Data Source:  BioPlex,STRINGDB
IFNA7
Tbio
Novelty:  0.14618009
Score:  0.927
Data Source:  STRINGDB
IFNA16
Tbio
Novelty:  0.1709941
Score:  0.919
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.917
Data Source:  STRINGDB
IFNA17
Tbio
Novelty:  0.0030696
Score:  0.917
Data Source:  STRINGDB
IFNAR1
Tclin
Novelty:  0.00175488
Score:  0.917
Data Source:  STRINGDB
IFNA4
Tbio
Novelty:  0.04421984
Score:  0.912
Data Source:  STRINGDB
IFNAR2
Tclin
Novelty:  0.00453303
Score:  0.912
Data Source:  STRINGDB
Pathways (90)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
1
1
0
1.7
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
0
1.7
38.2
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 19.46
PubMed score by year
PubTator Score 16.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title