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Tbio
IFNA2
Interferon alpha-2

Protein Summary
Description
Produced by macrophages, IFN-alpha have antiviral activities. This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded protein is a cytokine produced in response to viral infection. Use of the recombinant form of this protein has been shown to be effective in reducing the symptoms and duration of the common cold. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380206
  • ENSP00000369554
  • ENSG00000188379

Symbol
  • IFNA2A
  • IFNA2B
  • IFNA2C
  • IFNA
  • INFA2
  • IFNA2B
  • IFN-alphaA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
biological term
0.8
cell type or tissue
0.77
co-expressed gene
0.69
disease
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2820.61   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 988   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2820.61   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 988   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
6.5
lymphocyte percentage of leukocytes
1
1
1
1.8
neutrophil percentage of leukocytes
1
1
1
0.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
6.5
lymphocyte percentage of leukocytes
1
1.8
neutrophil percentage of leukocytes
1
0.6
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon alpha 2
VGNC:13898
473198
Macaque
interferon, alpha 2
709948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon alpha 2
Macaque
interferon, alpha 2
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (51)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Gene Ontology Terms (31)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (122)
1 – 10 of 122
ISG15
Tbio
Novelty: 0.00203781
p_int: 0.999998155
p_ni: 0.000001742
p_wrong: 1.03e-7
Score: 0.96
Data Source: BioPlex,STRINGDB
IFNA4
Tbio
Novelty: 0.04421984
p_int: 0.999893357
p_ni: 2e-9
p_wrong: 0.000106642
Score: 0.982
Data Source: BioPlex,STRINGDB
IFNA5
Tbio
Novelty: 0.02838784
p_int: 0.999497914
p_wrong: 0.000502085
Score: 0.861
Data Source: BioPlex,STRINGDB
PGLYRP1
Tbio
Novelty: 0.00231527
p_int: 0.992465304
p_ni: 0.007251264
p_wrong: 0.000283432
Score: 0.53
Data Source: BioPlex,STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
p_int: 0.987570439
p_ni: 0.001102266
p_wrong: 0.011327295
Score: 0.902
Data Source: BioPlex,STRINGDB
UBR3
Tbio
Family: Enzyme
Novelty: 0.14930754
p_int: 0.767179917
p_ni: 0.232820083
Score: 0.537
Data Source: BioPlex,STRINGDB
IFNAR1
Tclin
Novelty: 0.00175488
Score: 0.994
Data Source: STRINGDB
IFNAR2
Tclin
Novelty: 0.00453303
Score: 0.993
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.978
Data Source: STRINGDB
IRF3
Tbio
Family: TF
Novelty: 0.00099474
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  2820.61

PubMed score by year
PubTator Score  3033.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer