Protein Summary
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induce ...more
- ENST00000376122
- ENSP00000365290
- ENSG00000204490
- ENST00000383496
- ENSP00000372988
- ENSG00000206439
- ENST00000412275
- ENSP00000392858
- ENSG00000228321
- ENST00000420425
- ENSP00000410668
- ENSG00000228849
- ENST00000443707
- ENSP00000389492
- ENSG00000230108
- ENST00000448781
- ENSP00000389490
- ENSG00000223952
- ENST00000449264
- ENSP00000398698
- ENSG00000232810
- TNFA
- TNFSF2
- DIF
- TNFA
- TNFSF2
- TNLG1F
- TNF-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
virus perturbation | 1 | ||
drug | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 70327.4 (req: < 5)
Gene RIFs: 4125 (req: <= 3)
Antibodies: 4430 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 70327.4 (req: >= 5)
Gene RIFs: 4125 (req: > 3)
Antibodies: 4430 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 145
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 411
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (411)
Protein-Protein Interactions (1287)
TNFRSF1A
Novelty: 0.00037847
p_int: 0.999996794
p_ni: 0.000002275
p_wrong: 9.3e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DAG1
Family: Enzyme
Novelty: 0.00149278
p_int: 0.997018043
p_ni: 0.002981832
p_wrong: 1.25e-7
Score: 0.205
Data Source: BioPlex,STRINGDB
HSPA13
Novelty: 0.03895652
p_int: 0.988975416
p_ni: 0.011024584
Score: 0.603
Data Source: BioPlex,STRINGDB
GUF1
Novelty: 0.00422028
p_int: 0.979527956
p_ni: 0.019640972
p_wrong: 0.000831072
Score: 0.2
Data Source: BioPlex,STRINGDB
SFXN5
Novelty: 0.30379915
p_int: 0.974090509
p_ni: 0.024865901
p_wrong: 0.00104359
Data Source: BioPlex
NEK7
Family: Kinase
Novelty: 0.02675561
p_int: 0.973352473
p_ni: 0.02658634
p_wrong: 0.000061187
Score: 0.161
Data Source: BioPlex,STRINGDB
PLXNA2
Novelty: 0.01765957
p_int: 0.963544518
p_ni: 0.036404988
p_wrong: 0.000050495
Score: 0.153
Data Source: BioPlex,STRINGDB
GK
Family: Kinase
Novelty: 0.00617547
p_int: 0.961262842
p_ni: 0.038737158
Score: 0.202
Data Source: BioPlex,STRINGDB
CAPNS1
Novelty: 0.00954566
p_int: 0.960139914
p_ni: 0.039860086
Score: 0.328
Data Source: BioPlex,STRINGDB
HSPA12A
Novelty: 0.11999085
p_int: 0.956488665
p_ni: 0.043511328
p_wrong: 7e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (154)
Reactome (15)
KEGG (59)
PathwayCommons (25)
WikiPathways (55)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Developmental Biology | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-10 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Death Receptor Signalling | ||||
Developmental Biology | ||||
Immune System | ||||
Interleukin-10 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (156)
Functions (6)
Components (11)
Processes (139)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Disease Associations ()
GWAS Traits (700)
Items per page:
1 – 5 of 700
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 4 | 5 | 97.5 | ||||||
lymphocyte count | 3 | 4 | 5 | 97.5 | ||||||
lymphocyte count | 3 | 4 | 5 | 97.5 | ||||||
lymphocyte count | 3 | 4 | 5 | 97.5 | ||||||
lymphocyte count | 3 | 4 | 5 | 97.5 | ||||||
Items per page:
1 – 5 of 700
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte count | 5 | 97.5 | |||||
lymphocyte count | 5 | 97.5 | |||||
lymphocyte count | 5 | 97.5 | |||||
lymphocyte count | 5 | 97.5 | |||||
lymphocyte count | 5 | 97.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tumor necrosis factor | 494186 | ||||||
Mouse | MGI:104798 | 21926 | ||||||
Rat | RGD:3876 | 24835 | ||||||
Dog | tumor necrosis factor | VGNC:47647 | 403922 | |||||
Horse | tumor necrosis factor | VGNC:24357 | 100033834 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tumor necrosis factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | tumor necrosis factor | |||||
Horse | tumor necrosis factor | |||||
Publication Statistics
PubMed Score 70327.40
PubMed score by year
PubTator Score 45431.67
PubTator score by year
Related Publications
Text Mined References (5406)
GeneRif Annotations (4125)
Items per page:
0 of 0
PMID | Year | Title |
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