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Tclin
TNF
Tumor necrosis factor

Protein Summary
Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376122
  • ENSP00000365290
  • ENSG00000204490
  • ENST00000383496
  • ENSP00000372988
  • ENSG00000206439
  • ENST00000412275
  • ENSP00000392858
  • ENSG00000228321
  • ENST00000420425
  • ENSP00000410668
  • ENSG00000228849
  • ENST00000443707
  • ENSP00000389492
  • ENSG00000230108
  • ENST00000448781
  • ENSP00000389490
  • ENSG00000223952
  • ENST00000449264
  • ENSP00000398698
  • ENSG00000232810

Symbol
  • TNFA
  • TNFSF2
  • DIF
  • TNFA
  • TNFSF2
  • TNLG1F
  • TNF-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
virus perturbation
1
drug
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78397.92   (req: < 5)
Gene RIFs: 4125   (req: <= 3)
Antibodies: 4430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78397.92   (req: >= 5)
Gene RIFs: 4125   (req: > 3)
Antibodies: 4430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 145
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 449
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5