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Tclin
TNF
Tumor necrosis factor

Protein Summary
Description
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376122
  • ENSP00000365290
  • ENSG00000204490
  • ENST00000383496
  • ENSP00000372988
  • ENSG00000206439
  • ENST00000412275
  • ENSP00000392858
  • ENSG00000228321
  • ENST00000420425
  • ENSP00000410668
  • ENSG00000228849
  • ENST00000443707
  • ENSP00000389492
  • ENSG00000230108
  • ENST00000448781
  • ENSP00000389490
  • ENSG00000223952
  • ENST00000449264
  • ENSP00000398698
  • ENSG00000232810

Symbol
  • TNFA
  • TNFSF2
  • DIF
  • TNFA
  • TNFSF2
  • TNLG1F
  • TNF-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
virus perturbation
1
drug
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70327.4   (req: < 5)
Gene RIFs: 4125   (req: <= 3)
Antibodies: 4430   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70327.4   (req: >= 5)
Gene RIFs: 4125   (req: > 3)
Antibodies: 4430   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 145
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 411
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (1287)
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.999996794
p_ni:  0.000002275
p_wrong:  9.3e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
p_int:  0.997018043
p_ni:  0.002981832
p_wrong:  1.25e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
HSPA13
Tbio
Novelty:  0.03895652
p_int:  0.988975416
p_ni:  0.011024584
Score:  0.603
Data Source:  BioPlex,STRINGDB
GUF1
Tbio
Novelty:  0.00422028
p_int:  0.979527956
p_ni:  0.019640972
p_wrong:  0.000831072
Score:  0.2
Data Source:  BioPlex,STRINGDB
SFXN5
Tdark
Novelty:  0.30379915
p_int:  0.974090509
p_ni:  0.024865901
p_wrong:  0.00104359
Data Source:  BioPlex
NEK7
Tchem
Family:  Kinase
Novelty:  0.02675561
p_int:  0.973352473
p_ni:  0.02658634
p_wrong:  0.000061187
Score:  0.161
Data Source:  BioPlex,STRINGDB
PLXNA2
Tbio
Novelty:  0.01765957
p_int:  0.963544518
p_ni:  0.036404988
p_wrong:  0.000050495
Score:  0.153
Data Source:  BioPlex,STRINGDB
GK
Tbio
Family:  Kinase
Novelty:  0.00617547
p_int:  0.961262842
p_ni:  0.038737158
Score:  0.202
Data Source:  BioPlex,STRINGDB
CAPNS1
Tbio
Novelty:  0.00954566
p_int:  0.960139914
p_ni:  0.039860086
Score:  0.328
Data Source:  BioPlex,STRINGDB
HSPA12A
Tbio
Novelty:  0.11999085
p_int:  0.956488665
p_ni:  0.043511328
p_wrong:  7e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (154)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Interleukin-10 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Death Receptor Signalling
Developmental Biology
Immune System
Interleukin-10 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (156)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (700)
Items per page:
1 – 5 of 700
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
lymphocyte count
3
4
5
97.5
Items per page:
1 – 5 of 700
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
97.5
lymphocyte count
5
97.5
lymphocyte count
5
97.5
lymphocyte count
5
97.5
lymphocyte count
5
97.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor necrosis factor
494186
Mouse
MGI:104798
21926
Rat
RGD:3876
24835
Dog
tumor necrosis factor
VGNC:47647
403922
Horse
tumor necrosis factor
VGNC:24357
100033834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor necrosis factor
Mouse
Rat
Dog
tumor necrosis factor
Horse
tumor necrosis factor
Publication Statistics
PubMed Score 70327.40
PubMed score by year
PubTator Score 45431.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title