Tbio INS Insulin

Protein Summary

Description

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2019]

Uniprot Accession IDs

• P01308
• Q5EEX2

Gene Name

• INS

Ensembl ID

• ENST00000250971
• ENSP00000250971
• ENSG00000254647
• ENST00000381330
• ENSP00000370731
• ENST00000397262
• ENSP00000380432

Symbol

• IDDM
• ILPR
• IRDN
• IDDM1
• IDDM2
• MODY10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
phenotype	0.76
disease perturbation	0.74

Protein Classes

DTO Classes

Insulin-degrading Enzyme / Insulin-like Growth Factor 2 Mrna-binding Protein 1 / Insulin-like Growth Factor 2 Mrna-binding Protein 2 / Insulin-like Growth Factor 2 Mrna-binding Protein 3 / Early Placenta Insulin-like Peptide / Insulin-like Peptide Insl6 / Insulin-like Growth Factor-binding Protein 2 / Insulin-like Growth Factor-binding Protein 6 / Insulin-like Growth Factor-binding Protein 1 / Insulin-like Growth Factor-binding Protein 5 / Insulin-like Growth Factor-binding Protein 3 / Insulin-like Growth Factor-binding Protein 4 / Insulin-like Growth Factor-binding Protein Complex Acid Labile Subunit / Insulin Gene Enhancer Protein Isl-1 / Insulin Gene Enhancer Protein Isl-2 / Insulin Receptor / Insulin Receptor-related Protein / Insulin-like Growth Factor 1 Receptor / Glucose-dependent Insulinotropic Receptor / Insulinoma Cell / Insulinoma / Hyperinsulinemic Hypoglycemia / Hyperinsulinism / Insulin-like 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226021.99   (req: < 5)

Gene RIFs: 778   (req: <= 3)

Antibodies: 3206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226021.99   (req: >= 5)

Gene RIFs: 778   (req: > 3)

Antibodies: 3206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 68

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0