Tbio NPY Pro-neuropeptide Y

Protein Summary

Description

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P01303

Gene Name

• NPY

Ensembl ID

• ENST00000242152
• ENSP00000242152
• ENSG00000122585
• ENST00000405982
• ENSP00000385282
• ENST00000407573
• ENSP00000384364

Symbol

• PYY4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
PubMedID	0.86
disease	0.82
disease perturbation	0.79
chemical	0.77

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Pro-neuropeptide Y

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Pro-neuropeptide Y

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9091.26   (req: < 5)

Gene RIFs: 253   (req: <= 3)

Antibodies: 554   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9091.26   (req: >= 5)

Gene RIFs: 253   (req: > 3)

Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0