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Tbio
PPY
Pancreatic prohormone

Protein Summary
Description
Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. The physiological role for the icosapeptide has not yet been elucidated. This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225992
  • ENSP00000225992
  • ENSG00000108849
  • ENST00000591228
  • ENSP00000466009

Symbol
  • PNP
  • PP
  • PNP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.62
cell type or tissue
0.53
virus perturbation
0.5
tissue
0.49
pathway
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.54   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1297.54   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
4
3
5
96.7
high density lipoprotein cholesterol measurement
3
2
3
91.2
apolipoprotein A 1 measurement
1
1
1
87.7
metabolic syndrome
1
1
1
83
eosinophil count
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
96.7
high density lipoprotein cholesterol measurement
3
91.2
apolipoprotein A 1 measurement
1
87.7
metabolic syndrome
1
83
eosinophil count
1
66.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pancreatic polypeptide
739802
Macaque
pancreatic polypeptide
713988
Mouse
MGI:97753
19064
Rat
RGD:3385
24677
Dog
pancreatic polypeptide
VGNC:44933
490944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pancreatic polypeptide
Macaque
pancreatic polypeptide
Mouse
Rat
Dog
pancreatic polypeptide
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01298-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (308)
1 – 10 of 308
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999946379
p_ni:  0.000050493
p_wrong:  0.000003128
Data Source:  BioPlex
GPIHBP1
Tbio
Novelty:  0.01241227
p_int:  0.998149896
p_ni:  0.001654142
p_wrong:  0.000195962
Data Source:  BioPlex
SST
Tbio
Novelty:  0.00005944
Score:  0.99
Data Source:  STRINGDB
NPY4R
Tchem
Family:  GPCR
Novelty:  0.11465741
Score:  0.968
Data Source:  Reactome,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
Score:  0.96
Data Source:  Reactome,STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.957
Data Source:  STRINGDB
NPY1R
Tchem
Family:  GPCR
Novelty:  0.00438376
Score:  0.951
Data Source:  Reactome,STRINGDB
SSTR1
Tclin
Family:  GPCR
Novelty:  0.00588024
Score:  0.94
Data Source:  STRINGDB
SSTR5
Tclin
Family:  GPCR
Novelty:  0.00568309
Score:  0.94
Data Source:  STRINGDB
SSTR2
Tclin
Family:  GPCR
Novelty:  0.00200092
Score:  0.94
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1297.54

PubMed score by year
PubTator Score  699.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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