Protein Summary
GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
- ENST00000237527
- ENSP00000237527
- ENSG00000118702
- ENST00000373611
- ENSP00000362713
- ENST00000373614
- ENSP00000362716
- GHRF
- GRF
- INN
- GHRF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.87 | ||
gene perturbation | 0.83 | ||
disease | 0.66 | ||
biological term | 0.57 | ||
cell line | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1772.27 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 274 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1772.27 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 274 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (183)
Nearest Tclin Targets
Pathways (17)
Reactome (7)
KEGG (1)
PathwayCommons (6)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Glucagon-type ligand receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Glucagon-type ligand receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (4)
Components (6)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
suntan | 1 | 2 | 2 | 87 | |||||
body height | 1 | 1 | 1 | 36.9 | |||||
appendicular lean mass | 1 | 1 | 1 | 13 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
suntan | 2 | 87 | |||||
body height | 1 | 36.9 | |||||
appendicular lean mass | 1 | 13 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | growth hormone releasing hormone | VGNC:9862 | 469934 | |||||
Macaque | growth hormone releasing hormone | 701284 | ||||||
Mouse | MGI:95709 | 14601 | ||||||
Rat | RGD:61883 | 29446 | ||||||
Dog | growth hormone releasing hormone | VGNC:41207 | 485863 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | growth hormone releasing hormone | |||||
Macaque | growth hormone releasing hormone | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth hormone releasing hormone | |||||
Publication Statistics
PubMed Score 1772.27
PubMed score by year
PubTator Score 1750.47
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (42)
Items per page:
0 of 0
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