Tbio GHRH Somatoliberin

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Neuropeptide / Somatoliberin

DTO Classes

Protein / Signaling / Hormone / Neuropeptide / Somatoliberin

Protein Summary

Description

GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• P01286
• Q4KN10
• Q5JYR1

Gene Name

• GHRH

Ensembl ID

• ENST00000237527
• ENSP00000237527
• ENSG00000118702
• ENST00000373611
• ENSP00000362713
• ENST00000373614
• ENSP00000362716

Symbol

• GHRF
• GRF
• INN
• GHRF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
gene perturbation	0.83
disease	0.66
biological term	0.57
cell line	0.52

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.08   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 274   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.08   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	1	1	1		75.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
appendicular lean mass	EFO_0004980	1		75.1

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	growth hormone releasing hormone	VGNC:9862	469934
Macaque	growth hormone releasing hormone		701284
Mouse	growth hormone releasing hormone	MGI:95709	14601
Rat	growth hormone releasing hormone	RGD:61883	29446
Dog	growth hormone releasing hormone	VGNC:41207	485863

Species	Name	OMA	EggNOG	Inparanoid
Chimp	growth hormone releasing hormone
Macaque	growth hormone releasing hormone
Mouse	growth hormone releasing hormone
Rat	growth hormone releasing hormone
Dog	growth hormone releasing hormone

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01286-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (17)

Reactome (7)

KEGG (1)

PathwayCommons (6)

WikiPathways (3)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Glucagon-type ligand receptors	36 targets	R-HSA-420092

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Glucagon-type ligand receptors	36 targets	R-HSA-420092

Gene Ontology Terms (33)

Functions (4)

Components (6)

Processes (23)

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GO Term	Evidence	Assigned by
growth hormone-releasing hormone activity	Inferred from Direct Assay (IDA)	BHF-UCL
growth hormone-releasing hormone receptor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
neuropeptide hormone activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
peptide hormone receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (183)

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1 – 10 of 183

• See Interactions on String-DB

RAC3

Tbio

Family: Enzyme

Novelty: 0.02125361

p_int: 0.994112213

p_ni: 0.001350412

p_wrong: 0.004537375

Data Source: BioPlex

ADD3

Tbio

Family: Enzyme

Novelty: 0.02164464

p_int: 0.814443806

p_ni: 0.185553165

p_wrong: 0.000003029

Data Source: BioPlex

GHRHR

Tclin

Family: GPCR

Novelty: 0.00637611

Score: 0.996

Data Source: Reactome,STRINGDB

CRH

Tbio

Novelty: 0.000147

Score: 0.978

Data Source: STRINGDB

POMC

Tbio

Novelty: 0.00002436

Score: 0.977

Data Source: STRINGDB

SCT

Tbio

Novelty: 0.00070278

Score: 0.975

Data Source: STRINGDB

VIP

Tbio

Novelty: 0.00024946

Score: 0.974

Data Source: STRINGDB

ADCYAP1

Tbio

Family: Enzyme

Novelty: 0.00080219

Score: 0.97

Data Source: STRINGDB

GCG

Tchem

Novelty: 0.00004879

Score: 0.969

Data Source: STRINGDB

NPS

Tbio

Novelty: 0.00692108

Score: 0.966

Data Source: STRINGDB

Publication Statistics

PubMed Score  1757.08

PubMed score by year

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PubTator Score  1750.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Amidation
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Pharmaceutical
Polymorphism
Reference proteome
Secreted

GWAS Trait Find Similar Targets

appendicular lean mass

MGI Phenotype Find Similar Targets

adipose tissue phenotype
behavior/neurological phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
nervous system phenotype
reproductive system phenotype
skeleton phenotype